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A Fatal Reaction to Sulfobromophthalein

A Fatal Reaction to Sulfobromophthalein Widespread clinical use of the sulfobromophthalein (Bromsulphalein [BSP]) test since its introduction by Rosenthal in 19241 has confirmed the efficacy of this procedure as an index of hepatic parenchymal function. Less commonly appreciated are the hazards associated with the administration of the sulfobromophthalein dye. Of greatest importance is the rare, but frequently fatal, anaphylactoid reaction. This communication will summarize the serious reactions to sulfobromophthalein thus far reported and present the fifth known case of a fatal reaction. This represents the second reported case in which administration of sulfobromophthalein for the first time caused a fatal anaphylactoid reaction. Report of a Case This patient was a 41-year-old woman admitted to Hahnemann Hospital in 1959 with a chief complaint of epigastric and upper abdominal distress. She had noted upper abdominal fulness and bloating for six months, accompanied by eructations, nausea, and occasional vomiting. The symptoms were persistent and aggravated by most http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA American Medical Association

A Fatal Reaction to Sulfobromophthalein

JAMA , Volume 174 (14) – Dec 3, 1960

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References (8)

Publisher
American Medical Association
Copyright
Copyright © 1960 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.
ISSN
0098-7484
eISSN
1538-3598
DOI
10.1001/jama.1960.63030140006024
Publisher site
See Article on Publisher Site

Abstract

Widespread clinical use of the sulfobromophthalein (Bromsulphalein [BSP]) test since its introduction by Rosenthal in 19241 has confirmed the efficacy of this procedure as an index of hepatic parenchymal function. Less commonly appreciated are the hazards associated with the administration of the sulfobromophthalein dye. Of greatest importance is the rare, but frequently fatal, anaphylactoid reaction. This communication will summarize the serious reactions to sulfobromophthalein thus far reported and present the fifth known case of a fatal reaction. This represents the second reported case in which administration of sulfobromophthalein for the first time caused a fatal anaphylactoid reaction. Report of a Case This patient was a 41-year-old woman admitted to Hahnemann Hospital in 1959 with a chief complaint of epigastric and upper abdominal distress. She had noted upper abdominal fulness and bloating for six months, accompanied by eructations, nausea, and occasional vomiting. The symptoms were persistent and aggravated by most

Journal

JAMAAmerican Medical Association

Published: Dec 3, 1960

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