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Fromer Jl (1956)
Anaphylactoid drug reactions; recognition and management.The Lahey Clinic bulletin, 9
L. Mcvay (1953)
Near fatal reaction to sulfobromophthalein (bromsulphalein) liver test.Journal of the American Medical Association, 152 17
A. Andino, J. McKeown (1951)
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H. Walker, M. Koszalka (1957)
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J. Sievers, G. Morey, M. Samter (1949)
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J. Roth (1950)
Anaphylactoid reaction to sulfobromophthalein sodium.Journal of the American Medical Association, 143 9
J. Stecher (1959)
Fatal reaction to sulfobromophthalein.The New England journal of medicine, 261
Widespread clinical use of the sulfobromophthalein (Bromsulphalein [BSP]) test since its introduction by Rosenthal in 19241 has confirmed the efficacy of this procedure as an index of hepatic parenchymal function. Less commonly appreciated are the hazards associated with the administration of the sulfobromophthalein dye. Of greatest importance is the rare, but frequently fatal, anaphylactoid reaction. This communication will summarize the serious reactions to sulfobromophthalein thus far reported and present the fifth known case of a fatal reaction. This represents the second reported case in which administration of sulfobromophthalein for the first time caused a fatal anaphylactoid reaction. Report of a Case This patient was a 41-year-old woman admitted to Hahnemann Hospital in 1959 with a chief complaint of epigastric and upper abdominal distress. She had noted upper abdominal fulness and bloating for six months, accompanied by eructations, nausea, and occasional vomiting. The symptoms were persistent and aggravated by most
JAMA – American Medical Association
Published: Dec 3, 1960
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