Abstract • A Canadian family comprising 51 members affected with Alzheimer's disease was evaluated clinically, histologically, and genetically. Ancestors were traced through eight generations, and 51 members were examined at the National Institute of Mental Health, Bethesda, Md. The pedigree is consistent with autosomal dominant inheritance. The effect of interrelatedness among some parents of affected individuals is unknown. In contrast to other studies, there was not an increased incidence of Down's syndrome, hematologic malignancy, or preponderance of affected females. References 1. Smith A: Dreamthorp of death and the fear of dying , in Mortley C (ed): Bartlett's Familiar Quotations . Boston, Little Brown & Co, 1948, p 588. 2. Wang HS: Dementia of old age , in Smith WL, Kinsbourne M (eds): Aging and Dementia . New York, Spectrum Books, 1977, pp 1-24. 3. DeBoni U, McLachlan DRC: Senile dementia and Alzheimer's disease: A current view . Life Sci 1980;27:1-14.Crossref 4. Blackwood W, Corsellis JAN (eds): Greenfield's Neuropathology . London, Edward Arnold Publications Ltd, 1977, pp 796-848. 5. Alzheimer A: Uber eine eigenartige erkrankung der hirnrinde . Gesamte Psych 1907;64:146-148. 6. Cook RH, Ward BE, Austin JH: Studies in aging of the brain: IV. Familial Alzheimer's disease: Relation to transmissible dementia, aneuploidy, and microtubular defects . Neurology 1979;29:1402-1412.Crossref 7. Crapper DR, Krishnan SS, Dalton AJ: Alzheimer's disease and experimental neurofibrillary degeneration . Science 1973;180:511-513.Crossref 8. Davies P, Verth AH: Regional distribution of muscarinic acetylcholine receptor in normal and Alzheimer's type dementia brains . Brain Res 1978;138:385-392.Crossref 9. Goudsmit J, Morrow CH, Asher DM, et al: Evidence for and against the transmissibility of Alzheimer's disease . Neurology 1980;30:945-950.Crossref 10. Moreau-Dubois M, Brown P, Goudsmit J, et al: Biologic distinction between sporadic and familial Alzheimer's disease by an in vitro cell fusion test . Neurology 1981;31:323-325.Crossref 11. Heston LL, Lowther DL, Leventhal CM: Alzheimer's disease: A family study . Arch Neurol 1966;15:225-233.Crossref 12. Davidson EA, Robertson EE: Alzheimer's disease with acne rosacea in one of identical twins . J Neurol Neurosurg Psychiatry 1955;18:72-77.Crossref 13. Hunter R, Dayan AD, Wilson J: Alzheimer's disease in one monozygotic twin . J Neurol Neurosurg Psychiatry 1972;35:707-710.Crossref 14. Sulkava R, Rossi L, Knuutila: No elevated sister chromatid exchange in Alzheimer's disease . Acta Neurol Scand 1979;59:156-159.Crossref 15. Sjögren T, Sjögren H, Lindgren A: Morbus Alzheimer and morbus Pick: Genetic chemical and patho-anatomical study . Acta Psychiatr Neurol Scand 1952; (suppl 829) , pp 1-152. 16. Lowenberg K, Waggoner RW: Familial organic psychosis (Alzheimer's type) . Arch Neurol Psychiatry 1934;31:737-754.Crossref 17. Goudsmit J, White BJ, Weitkamp LR, et al: Familial Alzheimer's disease in two kindreds of the same geographic and ethnic origin: A clinical and genetic study . J Neurol Sci 1981;49:79-89.Crossref 18. Weingartner H, Gold P, Ballenger JC, et al: Effects of vasopressin on human memory functions . Science 1981;211:601-603.Crossref 19. Weingartner H, Kaye W, Smallberg SA, et al: Memory failures in progressive idiopathic dementia . J Abnorm Psychol 1981;90:187-196.Crossref 20. Sitaram N, Weingartner H, Gillin JC: Enhancement with arecoline and choline and impairment with scopolamine . Science 1978;201:274-276.Crossref 21. Weingartner H, Cohen RM, Murphy DJ, et al: Cognitive processes in depression . Arch Gen Psychiatry 1981;38:42-47.Crossref 22. Buskhke H: Selective reminding for analysis of memory and learning . J Verb Learning Verb Behav 1973;12:543-550.Crossref 23. Weitkamp LR, Nee LE, Keats B, et al: Alzheimer's disease: Evidence for susceptibility loci on chromosomes 6 and 14. Am J Hum Genet, in press. 24. Murdock JL, Walker BA, Hall JG, et al: Achondroplasia: A genetic and statistical survey . Ann Hum Genet 1970;33:227-244.Crossref 25. Penrose LS: The problem of anticipation in pedigrees of dystrophia myotonica . Ann Eugenics 1947-49;14:125-132.Crossref 26. Heston LL, Mastri AR: Genetics of Alzheimer's disease: Associations with hematologic malignancy and Down's syndrome . Arch Gen Psychiatry 1977;34:976-981.Crossref 27. Roth M: Epidemiological studies , in Katzman R, Terry RD, Bick KL (eds): Alzheimer's Disease: Senile Dementia and Related Disorders, 7, Aging . New York, Raven Press, 1978, pp 327-339. 28. Pro JD, Sumi M, Smith CH: Amyloid plaques in the cerebellum in presenile familial Alzheimer's disease . Neurology 1979;29:538-539.
Archives of Neurology – American Medical Association
Published: Apr 1, 1983
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