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A Family History of Seizures Associated With Sudden Cardiac Deaths

A Family History of Seizures Associated With Sudden Cardiac Deaths Abstract • Hereditary prolongation of the Q-T interval is associated with ventricular dysrhythmias. Children with hereditary prolongation of the Q-T interval may have symptoms that seem related to a neurologic abnormality. Two families had members who had been treated with phenytoin sodium for seizures and had died suddenly when the medication was discontinued. Children In both families were found to have prolongation of the Q-T interval. A history of seizures or of seizures in the family may be an indication of hereditary prolongation of the Q-T interval. (AJDC 1984;138:866-868) References 1. Gyllensward A: Fits of unusual origin . Acta Paediatr Scand 1957;46:642.Crossref 2. Moller T: Fits of unusual origin . Acta Paediatr Scand 1957;46:642.Crossref 3. Van Bruggen HW, Sebus J, Van Heyst ANP: Convulsive syncope resulting from arrhythmia in a case of congenital deafness with ECG abnormalities . Am Heart J 1969;78:81-86.Crossref 4. Ward OC: New familial cardiac syndrome in children . J Irish Med Assoc 1964;54:103-106. 5. Frank JD, Friedberg DZ: Syncope with prolonged QT interval . AJDC 1976;130:320-322. 6. Ballardie FW, Murphy RP, Davis J: Epilepsy: A presentation of the Romano-Ward syndrome . Br Med J 1983;287:896-897.Crossref 7. Jervell A, Lange-Nielsen F: Congenital deaf-mutism: Functional heart disease with prolongation of the Q-T interval, and sudden death . Am Heart J 1957;54:59-68.Crossref 8. Romano C, Gemme G, Pongigloine R: Aritmie cardiache rare dell' eta pediatrica . Clin Pediatr 1963;45:656-683. 9. Fraser GR, Froggat P, Murphy T: Genetical aspects of the cardio-auditory syndrome of Jervell and Lange-Nielsen (congenital deafness and electrocardiographic abnormalities) . Ann Hum Genet 1964;28:133-157.Crossref 10. Jervell A: Surdocardiac and related syndromes in children . Adv Intern Med 1971;17: 425-438. 11. Fraser GR: Unexpected deaths . Lancet 1966;2:56-57.Crossref 12. Fraser GR: Cardioauditory syndrome , in Bergsma D (ed): Birth Defects Atlas and Compendium . Baltimore, Williams & Wilkins Co, 1973, p 221. 13. Langslet A, Sorland SJ: Changes in ECG and cardiac rhythm with epilepsy-like attack and sudden death in childhood . Tidsskr Nor Laegeforen 1974;94:632-635. 14. Bronsky D, Dubin A, Waldwtein SS, et al: Calcium and the electrocardiogram . Am J Cardiol 1961;7:823-832.Crossref 15. Lepeschkin E, Surawicz B: Electrocardiographic aspects of hypopotassemia . Heart Bull 1958;7:114-116. 16. Liebman J: Pediatric Electrocardiography . Baltimore, Williams & Wilkins Co, 1982, p 194. 17. Setak KR, Hellerston EE, Lown B, et al: Effect of potassium and magnesium deficiency on the electrocardiogram and plasma electrolytes of pure-bred beagles . Am J Cardiol 1966;17: 516-519.Crossref 18. Khan MM, Logan KR, McComb JM, et al: Management of recurrent ventricular tachycardia associated with Q-T prolongation . Am J Cardiol 1981;47:1301-1308.Crossref 19. Taran LM, Szilagyi N: The duration of the electrical systole (Q-T) in acute rheumatic carditis in childhood . Am Heart J 1947;33:14-26.Crossref 20. Gittleman IW, Thorner MC, Griffiths GC: Q-T interval of the electrocardiogram in acute myocarditis in adults, with autopsy correlation . Am Heart J 1951;41:78-90.Crossref 21. Phang SH, White PD: Duration of ventricular systole as measured by the Q-T interval of the electrocardiogram with special reference to cardiac enlargement with and without congestive failure . Am Heart J 1943;26:108-113.Crossref 22. Goldman MJ: Principles of Clinical Electrocardiography . Los Altos, Calif, Lange Medical Publications, 1970, p 300. 23. Krasnoff SO: The duration of the Q-T interval in myocardial infarction . Am Heart J 1950; 39:523-531.Crossref 24. Burch GE, Myers R, Abildskov JA: A new electrocardiographic pattern observed in cerebrovascular accidents . Circulation 1954;9: 719-723.Crossref 25. Swartz MH, Teichholz LE, Conoso E: Mitral valve prolapse: A review of associated arrhythmias . Am J Med 1977;62:377-389.Crossref 26. Emslie-Smith D, Sladden GE, Stirling GR: The significance of changes in the electrocardiogram in hypothermia . Br Heart J 1959;21: 343-351.Crossref 27. Schwartz PJ, Pereti M, Malliani A: The long Q-T syndrome . Am Heart J 1975;89:378-390.Crossref 28. Chaudron JM, Heller F, Van den Berghe HB, et al: Attacks of ventricular fibrillation and unconsciousness in a patient with prolonged Q-T interval: A family study . Am Heart J 1976;91: 783-791.Crossref 29. Garson A: The Electrocardiogram in Infants and Children: A Systematic Approach . Philadelphia, Lea & Febiger, 1983. 30. Bazett HC: An analysis of the time relationship of the electrocardiogram . Heart 1920;7: 353-370. 31. Anderson VE: Family studies of epilepsy , in Anderson VE, Hauser WH, Perry JK, et al (eds): Genetics Basis of the Epilepsies . New York, Raven Press, 1982, pp 103-112. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png American Journal of Diseases of Children American Medical Association

A Family History of Seizures Associated With Sudden Cardiac Deaths

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Publisher
American Medical Association
Copyright
Copyright © 1984 American Medical Association. All Rights Reserved.
ISSN
0002-922X
DOI
10.1001/archpedi.1984.02140470064021
Publisher site
See Article on Publisher Site

Abstract

Abstract • Hereditary prolongation of the Q-T interval is associated with ventricular dysrhythmias. Children with hereditary prolongation of the Q-T interval may have symptoms that seem related to a neurologic abnormality. Two families had members who had been treated with phenytoin sodium for seizures and had died suddenly when the medication was discontinued. Children In both families were found to have prolongation of the Q-T interval. A history of seizures or of seizures in the family may be an indication of hereditary prolongation of the Q-T interval. (AJDC 1984;138:866-868) References 1. Gyllensward A: Fits of unusual origin . Acta Paediatr Scand 1957;46:642.Crossref 2. Moller T: Fits of unusual origin . Acta Paediatr Scand 1957;46:642.Crossref 3. Van Bruggen HW, Sebus J, Van Heyst ANP: Convulsive syncope resulting from arrhythmia in a case of congenital deafness with ECG abnormalities . Am Heart J 1969;78:81-86.Crossref 4. Ward OC: New familial cardiac syndrome in children . J Irish Med Assoc 1964;54:103-106. 5. Frank JD, Friedberg DZ: Syncope with prolonged QT interval . AJDC 1976;130:320-322. 6. Ballardie FW, Murphy RP, Davis J: Epilepsy: A presentation of the Romano-Ward syndrome . Br Med J 1983;287:896-897.Crossref 7. Jervell A, Lange-Nielsen F: Congenital deaf-mutism: Functional heart disease with prolongation of the Q-T interval, and sudden death . Am Heart J 1957;54:59-68.Crossref 8. Romano C, Gemme G, Pongigloine R: Aritmie cardiache rare dell' eta pediatrica . Clin Pediatr 1963;45:656-683. 9. Fraser GR, Froggat P, Murphy T: Genetical aspects of the cardio-auditory syndrome of Jervell and Lange-Nielsen (congenital deafness and electrocardiographic abnormalities) . Ann Hum Genet 1964;28:133-157.Crossref 10. Jervell A: Surdocardiac and related syndromes in children . Adv Intern Med 1971;17: 425-438. 11. Fraser GR: Unexpected deaths . Lancet 1966;2:56-57.Crossref 12. Fraser GR: Cardioauditory syndrome , in Bergsma D (ed): Birth Defects Atlas and Compendium . Baltimore, Williams & Wilkins Co, 1973, p 221. 13. Langslet A, Sorland SJ: Changes in ECG and cardiac rhythm with epilepsy-like attack and sudden death in childhood . Tidsskr Nor Laegeforen 1974;94:632-635. 14. Bronsky D, Dubin A, Waldwtein SS, et al: Calcium and the electrocardiogram . Am J Cardiol 1961;7:823-832.Crossref 15. Lepeschkin E, Surawicz B: Electrocardiographic aspects of hypopotassemia . Heart Bull 1958;7:114-116. 16. Liebman J: Pediatric Electrocardiography . Baltimore, Williams & Wilkins Co, 1982, p 194. 17. Setak KR, Hellerston EE, Lown B, et al: Effect of potassium and magnesium deficiency on the electrocardiogram and plasma electrolytes of pure-bred beagles . Am J Cardiol 1966;17: 516-519.Crossref 18. Khan MM, Logan KR, McComb JM, et al: Management of recurrent ventricular tachycardia associated with Q-T prolongation . Am J Cardiol 1981;47:1301-1308.Crossref 19. Taran LM, Szilagyi N: The duration of the electrical systole (Q-T) in acute rheumatic carditis in childhood . Am Heart J 1947;33:14-26.Crossref 20. Gittleman IW, Thorner MC, Griffiths GC: Q-T interval of the electrocardiogram in acute myocarditis in adults, with autopsy correlation . Am Heart J 1951;41:78-90.Crossref 21. Phang SH, White PD: Duration of ventricular systole as measured by the Q-T interval of the electrocardiogram with special reference to cardiac enlargement with and without congestive failure . Am Heart J 1943;26:108-113.Crossref 22. Goldman MJ: Principles of Clinical Electrocardiography . Los Altos, Calif, Lange Medical Publications, 1970, p 300. 23. Krasnoff SO: The duration of the Q-T interval in myocardial infarction . Am Heart J 1950; 39:523-531.Crossref 24. Burch GE, Myers R, Abildskov JA: A new electrocardiographic pattern observed in cerebrovascular accidents . Circulation 1954;9: 719-723.Crossref 25. Swartz MH, Teichholz LE, Conoso E: Mitral valve prolapse: A review of associated arrhythmias . Am J Med 1977;62:377-389.Crossref 26. Emslie-Smith D, Sladden GE, Stirling GR: The significance of changes in the electrocardiogram in hypothermia . Br Heart J 1959;21: 343-351.Crossref 27. Schwartz PJ, Pereti M, Malliani A: The long Q-T syndrome . Am Heart J 1975;89:378-390.Crossref 28. Chaudron JM, Heller F, Van den Berghe HB, et al: Attacks of ventricular fibrillation and unconsciousness in a patient with prolonged Q-T interval: A family study . Am Heart J 1976;91: 783-791.Crossref 29. Garson A: The Electrocardiogram in Infants and Children: A Systematic Approach . Philadelphia, Lea & Febiger, 1983. 30. Bazett HC: An analysis of the time relationship of the electrocardiogram . Heart 1920;7: 353-370. 31. Anderson VE: Family studies of epilepsy , in Anderson VE, Hauser WH, Perry JK, et al (eds): Genetics Basis of the Epilepsies . New York, Raven Press, 1982, pp 103-112.

Journal

American Journal of Diseases of ChildrenAmerican Medical Association

Published: Sep 1, 1984

References

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