Abstract • An acellular pertussis—component diphtheria-tetanus-pertussis (AC-DTP) vaccine was compared with a currently licensed, whole-cell pertussis—component DTP (WC-DTP) vaccine for reactogenicity and immunogenicity when given as the fourth DTP immunization in sixty 18- to 24-month-old children. Reactions over the first 48 hours were significantly less common in the AC-DTP vaccine recipients, as follows (WC-DTP/AC-DTP): fever, 85%/5%; redness, 70%/12.5%; tenderness, 100%/22.5%; swelling, 35%/10%; fretfulness, 70%/12.5%; anorexia, 35%/2.5%; and vomiting, 10%/0%. Antibody responses to pertussis antigens (agglutinogens, lymphocytosis-promoting factor, and filamentous hemagglutinin), diphtheria toxoid, and tetanus toxoid in AC-DTP vaccine recipients were comparable with those in WC-DTP vaccine recipients. The AC-DTP vaccine evaluated in this trial seems to be as immunogenic as WC-DTP vaccine while being markedly less reactogenic. (AJDC 1986;140:872-876) References 1. Cherry JD: The epidemiology of pertussis and pertussis immunization in the United Kingdom and the United States: A comparative study . Curr Probl Pediatr 1984;14:1-78.Crossref 2. Sato Y, Kimura M, Fukumi H: Development of a pertussis component vaccine in Japan . Lancet 1984;1:122-126.Crossref 3. Aoyama T, Murase Y, Kato T, et al: Efficacy of an acellular pertussis vaccine in Japan . J Pediatr 1985;107:180-183.Crossref 4. Manclark CR, Cowell JL: Pertussis , in Germanier R (ed): Bacterial Vaccines . Orlando, Fla, Academic Press Inc, 1984, pp 69-106. 5. Lewis K, Cherry JD, Baraff LJ, et al: An open study evaluating the reactogenicity and immunogenicity of a DTP vaccine containing an acellular pertussis component . Dev Biol Stand 1985;61:563-569. 6. Isomura S, Suzuki S, Sato Y: Clinical efficacy of the Japanese pertussis component vaccine after intrafamiliar exposure to pertussis patients . Dev Biol Stand 1985;61:531-537. 7. Kimura M, Hikino N: Results with a new DTP vaccine in Japan . Dev Biol Stand 1985;61: 545-561. 8. Sato Y, Sato H, Izumiya K, et al: Role of antibody to filamentous hemagglutinin and to leukocytosis promoting factor—hemagglutinin in immunity to infection , in Weinstein L, Fields B (eds): Seminars in Infectious Disease: Bacterial Vaccines . New York, Thieme-Stratton Inc, 1982, pp 380-385. 9. Oda M, Cowell JL, Burstyn DG, et al: Protective activities of the filamentous hemagglutinin and the lymphocytosis-promoting factor of Bordetella pertussis in mice . J Infect Dis 1984;6:823-833.Crossref 10. Report of the Committee on Infectious Diseases (Red Book) , ed 19. Evanston, Ill, American Academy of Pediatrics, 1982, pp 198-202. 11. Manclark CR, Meade BD: Serologic response to Bordetella pertussis , in Rose NR, Friedman N (eds): Manual of Clinical Immunology . Washington, DC, American Society for Microbiology, 1980, pp 497-499. 12. Voller A, Bidwell DE, Bartlett A: The Enzyme-Linked Immunosorbent Assay (ELISA) . Alexandria, Va, Dynatech Laboratories Inc, 1979. 13. Cowell JL, Sato Y, Sato H, et al: Separation, purification, and properties of the filamentous hemagglutinin and the leukocytosis promoting factor hemagglutinin , in Weinstein L, Fields B (eds): Seminars in Infectious Disease: Bacterial Vaccines . New York, Thieme-Stratton Inc, 1982, pp 371-379. 14. Millian SJ, Cherubin CE, Sherwin R, et al: A serologic survey of tetanus and diphtheria immunity in New York City . Arch Environ Health 1967;15:776-781.Crossref 15. Querillon M, Chagon A: Microtissue culture test for the titration of low concentrations of diphtheria antitoxin in minimal amounts of human sera . Appl Microbiol 1973;25:1-4. 16. Kimura M, Hikino N: Results with a new DTP vaccine in Japan . Dev Biol Stand 1985;61: 545-561. 17. Wardlaw AC, Parton R: Pertussis vaccine , in Easmon CFF, Jeljaszewicz J (eds): Medical Microbiology . Orlando, Fla, Academic Press Inc, 1983, pp 207-253. 18. Baraff LJ, Cherry JD, Marcy SM, et al: DTP reactions: Relationship of manufacturer lot, potency and endotoxin to reaction rates . Clin Res 1986;34:129A. 19. Miller JJ, Silverberg RJ, Saito TM, et al: An agglutinative reaction for Hemophilus pertussis . J Pediatr 1943;22:644-651.Crossref 20. Schuchardt LF, Munoz J, Verwey WF, et al: The relationship of agglutinogen to other antigens of Bordetella pertussis . J Immunol 1963;91:107-111. 21. Cherry JD, Shields WD: Recurrent seizures after diphtheria, tetanus, and pertussis immunization . AJDC 1984;138:904-907.
American Journal of Diseases of Children – American Medical Association
Published: Sep 1, 1986