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A DISCOLORATION OF THE SKIN AND MUCOUS MEMBRANES RESEMBLING ARGYRIA, FOLLOWING THE USE OF BISMUTH AND SILVER ARSPHENAMINE: REPORT OF THREE CASES WITH MICROSCOPIC EXAMINATION, INCLUDING SPECTROGRAPHIC AND CHEMICAL ANALYSES OF THE TISSUES

A DISCOLORATION OF THE SKIN AND MUCOUS MEMBRANES RESEMBLING ARGYRIA, FOLLOWING THE USE OF BISMUTH... Abstract The increase in the use of silver arsphenamine in the treatment for syphilis, not only in late cerebrospinal lesions, but in the earlier manifestations, shows that it is recognized by numerous syphilologists as a potent remedy. Some clinicians have avoided this preparation because of the possibility that it might cause argyria. In an extended use of silver arsphenamine in the treatment for both early and late syphilis during the past eight years, I have been greatly impressed with the results obtained from the use of this drug. It has shown excellent compatibility with the body fluids, as manifested by its low toxicity and the absence of unfavorable reactions following its use, especially when given in intensive dosage and according to the methods advocated by Pollitzer,1 Kolmer2 and others in the treatment for early syphilis. Habermann.3 Sioli4 and Mucha5 stated that argyria might occur after 15 References 1. Pollitzer, S.: The Principles of the Treatment of Syphilis , J. Cutan. Dis. 34:633 ( (Sept.) ) 1916. 2. Kolmer, John A.: Principles and Practice of Chemotherapy , Philadelphia, W. B. Saunders Company, 1926, p. 953. 3. Habermann, R.: Ueber Argyria cutis nach Silbersalvarsan und den Wert der Leuchtbildmethode E. Hoffmans für ihren Nachweis , Dermat. Ztschr. 40:65 ( (Jan.) ) 1924.Crossref 4. Sioli, F., quoted by Habermann: Congress of the German Dermatological Society , Munich, (May 20) -24, 1923. 5. Mucha, quoted by Habermann: Congress of the German Dermatological Society , Munich, (May 20) -24, 1923. 6. Myers, C. N., and Corbitt, H. B.: Retention and Elimination of Silver with Special Reference to Silver Salvarsan and Silver Therapy , Am. J. Syph. 8:4 ( (Oct.) ) 1924. 7. Myers, C. N.: Argyria and Its Relation to Silver Therapy , Am. J. Syph. 7:1 ( (Jan.) ) 1923 8. Silver Salvarsan, Qualitative and Quantitative Studies , Am. J. Syph. 6:1 ( (Jan.) ) 1922. 9. Hooper, C. W., and Myers, C. N.: Histopathologic and Blood Studies with Silver Salvarsan , J. Lab. & Clin. Med. 10:3 ( (Dec.) ) 1924. 10. Kogoj, F.: Argyrie und Arsenmelanose der Haut und Schleimhaute nach Silver und Neosalvarsan , Acta dermat.-venereol. 4:95 ( (March) ) 1923. 11. Muller, H.; Blass, and Kratzeisen: Experimentelles mikroskopisches und klinisches zur Wismuthbehandlung bei Syphilis (Nadison Kalle) , München. med. Wchnschr. 70:625, 1923. 12. Dietel, quoted by Juliusberg, Fritz: Handbuch der Haut und Geschlechtskrankheiten: Syphilis Therapie , Berlin, Julius Springer, 1928, vol. 18, p. 442. 13. Rosenberg, Hans; and Perdelwitz, Paul: Die Behandlung der Syphilis mit reinem Wismut (Sorbismol Agfa) , Dermat. Wchnschr. 78:422, 1924. 14. Lohe, H., and Rosenfeld, H.: Untersuchungen über den Wismutsaum und seine Beziehungen zum Gesamtorganismus , Dermat. Ztschr. 50:409, 1927. 15. Stillians, A. W., and Lawless, T. K.: An Intracutaneous Method of Treating Argyria , Arch. Dermat. & Syph. 17:153 ( (Feb.) ) 1928 16. The Intradermal Treatment of Argyria , J. A. M. A. 92:20 ( (Jan. 5) ) 1920 17. Stillians, A. W., in discussion on Wile: Argyrosis , Arch. Dermat. & Syph. 20:535 ( (Oct.) ) 1929. 18. Gans, Oscar: Histologie der Hautkrankheiten , Berlin, Julius Springer, 1928, vol. 2, p. 154. 19. Azoulay, Robert: Stomatite bismuthique , Presse méd. 30:134, 1922. 20. Strempel, R., and Armuzzi, G.: Zur Histopathologie der Wismutstomatitis mit experimentellen Beiträgen , Dermat. Ztschr. 42:1, 1924. 21. Lowenfeld, W.: Wismutsaum nach Nadisan Injecktionen , Zentralbl. f. Haut- u. Geschlechtskr. 13:36, 1924. 22. Hoffmann, Erich: Die Bedeutung des Dunkelfelds für die Untersuchung der Gelbfieber, Syphilis- und anderer Spirochäten sowie sonstiger Mikroorganismen und Schnitten (Leuchtbildmethode) , Berl. klin. Wchnschr. 4:73, 1921 23. Die als Leuchtbildmethode bezeichnete Art der Dunkelfelduntersuchung , in Kraus, Rudolf; and Uhlenhuth, Paul: Handbuch der mikrobiologischen Technik , Berlin, Urban & Schwarzenberg, 1922, vol. 1, p. 70. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Dermatology and Syphilology American Medical Association

A DISCOLORATION OF THE SKIN AND MUCOUS MEMBRANES RESEMBLING ARGYRIA, FOLLOWING THE USE OF BISMUTH AND SILVER ARSPHENAMINE: REPORT OF THREE CASES WITH MICROSCOPIC EXAMINATION, INCLUDING SPECTROGRAPHIC AND CHEMICAL ANALYSES OF THE TISSUES

Archives of Dermatology and Syphilology , Volume 23 (2) – Feb 1, 1931

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Publisher
American Medical Association
Copyright
Copyright © 1931 American Medical Association. All Rights Reserved.
ISSN
0096-6029
DOI
10.1001/archderm.1931.03880200056005
Publisher site
See Article on Publisher Site

Abstract

Abstract The increase in the use of silver arsphenamine in the treatment for syphilis, not only in late cerebrospinal lesions, but in the earlier manifestations, shows that it is recognized by numerous syphilologists as a potent remedy. Some clinicians have avoided this preparation because of the possibility that it might cause argyria. In an extended use of silver arsphenamine in the treatment for both early and late syphilis during the past eight years, I have been greatly impressed with the results obtained from the use of this drug. It has shown excellent compatibility with the body fluids, as manifested by its low toxicity and the absence of unfavorable reactions following its use, especially when given in intensive dosage and according to the methods advocated by Pollitzer,1 Kolmer2 and others in the treatment for early syphilis. Habermann.3 Sioli4 and Mucha5 stated that argyria might occur after 15 References 1. Pollitzer, S.: The Principles of the Treatment of Syphilis , J. Cutan. Dis. 34:633 ( (Sept.) ) 1916. 2. Kolmer, John A.: Principles and Practice of Chemotherapy , Philadelphia, W. B. Saunders Company, 1926, p. 953. 3. Habermann, R.: Ueber Argyria cutis nach Silbersalvarsan und den Wert der Leuchtbildmethode E. Hoffmans für ihren Nachweis , Dermat. Ztschr. 40:65 ( (Jan.) ) 1924.Crossref 4. Sioli, F., quoted by Habermann: Congress of the German Dermatological Society , Munich, (May 20) -24, 1923. 5. Mucha, quoted by Habermann: Congress of the German Dermatological Society , Munich, (May 20) -24, 1923. 6. Myers, C. N., and Corbitt, H. B.: Retention and Elimination of Silver with Special Reference to Silver Salvarsan and Silver Therapy , Am. J. Syph. 8:4 ( (Oct.) ) 1924. 7. Myers, C. N.: Argyria and Its Relation to Silver Therapy , Am. J. Syph. 7:1 ( (Jan.) ) 1923 8. Silver Salvarsan, Qualitative and Quantitative Studies , Am. J. Syph. 6:1 ( (Jan.) ) 1922. 9. Hooper, C. W., and Myers, C. N.: Histopathologic and Blood Studies with Silver Salvarsan , J. Lab. & Clin. Med. 10:3 ( (Dec.) ) 1924. 10. Kogoj, F.: Argyrie und Arsenmelanose der Haut und Schleimhaute nach Silver und Neosalvarsan , Acta dermat.-venereol. 4:95 ( (March) ) 1923. 11. Muller, H.; Blass, and Kratzeisen: Experimentelles mikroskopisches und klinisches zur Wismuthbehandlung bei Syphilis (Nadison Kalle) , München. med. Wchnschr. 70:625, 1923. 12. Dietel, quoted by Juliusberg, Fritz: Handbuch der Haut und Geschlechtskrankheiten: Syphilis Therapie , Berlin, Julius Springer, 1928, vol. 18, p. 442. 13. Rosenberg, Hans; and Perdelwitz, Paul: Die Behandlung der Syphilis mit reinem Wismut (Sorbismol Agfa) , Dermat. Wchnschr. 78:422, 1924. 14. Lohe, H., and Rosenfeld, H.: Untersuchungen über den Wismutsaum und seine Beziehungen zum Gesamtorganismus , Dermat. Ztschr. 50:409, 1927. 15. Stillians, A. W., and Lawless, T. K.: An Intracutaneous Method of Treating Argyria , Arch. Dermat. & Syph. 17:153 ( (Feb.) ) 1928 16. The Intradermal Treatment of Argyria , J. A. M. A. 92:20 ( (Jan. 5) ) 1920 17. Stillians, A. W., in discussion on Wile: Argyrosis , Arch. Dermat. & Syph. 20:535 ( (Oct.) ) 1929. 18. Gans, Oscar: Histologie der Hautkrankheiten , Berlin, Julius Springer, 1928, vol. 2, p. 154. 19. Azoulay, Robert: Stomatite bismuthique , Presse méd. 30:134, 1922. 20. Strempel, R., and Armuzzi, G.: Zur Histopathologie der Wismutstomatitis mit experimentellen Beiträgen , Dermat. Ztschr. 42:1, 1924. 21. Lowenfeld, W.: Wismutsaum nach Nadisan Injecktionen , Zentralbl. f. Haut- u. Geschlechtskr. 13:36, 1924. 22. Hoffmann, Erich: Die Bedeutung des Dunkelfelds für die Untersuchung der Gelbfieber, Syphilis- und anderer Spirochäten sowie sonstiger Mikroorganismen und Schnitten (Leuchtbildmethode) , Berl. klin. Wchnschr. 4:73, 1921 23. Die als Leuchtbildmethode bezeichnete Art der Dunkelfelduntersuchung , in Kraus, Rudolf; and Uhlenhuth, Paul: Handbuch der mikrobiologischen Technik , Berlin, Urban & Schwarzenberg, 1922, vol. 1, p. 70.

Journal

Archives of Dermatology and SyphilologyAmerican Medical Association

Published: Feb 1, 1931

References

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