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A Dermatologic and Psychiatric Study of Perphenazine (Trilafon) in Dermatology

A Dermatologic and Psychiatric Study of Perphenazine (Trilafon) in Dermatology Abstract The purpose of this study was to evaluate the effect of a new tranquilizing agent, perphenazine (Trilafon) in dermatologic patients. No effort was made to determine the critical influence of perphenazine on the dermatitis, but only the effect on pruritus and the subjective state of the individual. It was also the purpose to determine whether or not the pharmacologic agent has any undesirable side-effects. This study of a new tranquilizer was done with the active cooperation of the Department of Psychiatry, and cases were used from both dermatology and psychiatry. Material and Methods Perphenazine (1-[2-hydroxyethyl]-4-[3-(2-chloro-10-phenthiazyl)-propyl]-piperazine) is a phenothiazine derivative with behavioral effects in animals and men generally similar to chlorpromazine. It is, however, five to seven times as potent as the latter in its effects on behavior without increase in toxicity. Three hundred eight patients, 205 women and 103 men, with several skin diseases were References 1. Ayd, F. J., Jr.: J. Am. Geriatrics Soc. 5:92 ( (Jan.) ) 1957. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png A.M.A. Archives of Dermatology American Medical Association

A Dermatologic and Psychiatric Study of Perphenazine (Trilafon) in Dermatology

A.M.A. Archives of Dermatology , Volume 77 (1) – Jan 1, 1958

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Publisher
American Medical Association
Copyright
Copyright © 1958 American Medical Association. All Rights Reserved.
ISSN
0096-5359
DOI
10.1001/archderm.1958.01560010121024
Publisher site
See Article on Publisher Site

Abstract

Abstract The purpose of this study was to evaluate the effect of a new tranquilizing agent, perphenazine (Trilafon) in dermatologic patients. No effort was made to determine the critical influence of perphenazine on the dermatitis, but only the effect on pruritus and the subjective state of the individual. It was also the purpose to determine whether or not the pharmacologic agent has any undesirable side-effects. This study of a new tranquilizer was done with the active cooperation of the Department of Psychiatry, and cases were used from both dermatology and psychiatry. Material and Methods Perphenazine (1-[2-hydroxyethyl]-4-[3-(2-chloro-10-phenthiazyl)-propyl]-piperazine) is a phenothiazine derivative with behavioral effects in animals and men generally similar to chlorpromazine. It is, however, five to seven times as potent as the latter in its effects on behavior without increase in toxicity. Three hundred eight patients, 205 women and 103 men, with several skin diseases were References 1. Ayd, F. J., Jr.: J. Am. Geriatrics Soc. 5:92 ( (Jan.) ) 1957.

Journal

A.M.A. Archives of DermatologyAmerican Medical Association

Published: Jan 1, 1958

References