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A Dental Depot in Penicillin Hypersensitivity

A Dental Depot in Penicillin Hypersensitivity Abstract The search for the source of antigen in a penicillin-sensitive patient can be a difficult and frustrating experience. The physician must be aware of diverse and unusual ways in which the drug can be introduced into the system. The milk of cattle treated with penicillin is now a well-known contact,1 as is poliomyelitis vaccine, but syringes contaminated by trace amount of the drug, penicillin-containing air, penicillin troches and ointment, and penicillin injected into cysts are other possible sources of exposure.2 Recently, I studied a 16-year-old white girl with acute urticaria resulting from the administration of penicillin in a paste used in endodontal repair of a tooth. At first I dismissed this site as a route of entry for the drug, since I thought that absorption into the systemic circulation after instillation into the dental root canal did not occur. However, further exploration revealed that systemic absorption from the References 1. Zimmerman, M.: Chronic Penicillin Urticaria from Dairy Products Proved by Penicillinase Cures , A.M.A. Arch. Derm. 79:1, 1959.Crossref 2. Siegel, B. B.: Hidden Contacts with Penicillin , Bull. W.H.O. 21:703, 1959. 3. Grossman, L. I.: Root Canal Therapy , Philadelphia, Lea & Febiger, 1955. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Dermatology American Medical Association

A Dental Depot in Penicillin Hypersensitivity

Archives of Dermatology , Volume 87 (3) – Mar 1, 1963

A Dental Depot in Penicillin Hypersensitivity

Abstract

Abstract The search for the source of antigen in a penicillin-sensitive patient can be a difficult and frustrating experience. The physician must be aware of diverse and unusual ways in which the drug can be introduced into the system. The milk of cattle treated with penicillin is now a well-known contact,1 as is poliomyelitis vaccine, but syringes contaminated by trace amount of the drug, penicillin-containing air, penicillin troches and ointment, and penicillin injected into cysts are other...
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Publisher
American Medical Association
Copyright
Copyright © 1963 American Medical Association. All Rights Reserved.
ISSN
0003-987X
eISSN
1538-3652
DOI
10.1001/archderm.1963.01590150103020
Publisher site
See Article on Publisher Site

Abstract

Abstract The search for the source of antigen in a penicillin-sensitive patient can be a difficult and frustrating experience. The physician must be aware of diverse and unusual ways in which the drug can be introduced into the system. The milk of cattle treated with penicillin is now a well-known contact,1 as is poliomyelitis vaccine, but syringes contaminated by trace amount of the drug, penicillin-containing air, penicillin troches and ointment, and penicillin injected into cysts are other possible sources of exposure.2 Recently, I studied a 16-year-old white girl with acute urticaria resulting from the administration of penicillin in a paste used in endodontal repair of a tooth. At first I dismissed this site as a route of entry for the drug, since I thought that absorption into the systemic circulation after instillation into the dental root canal did not occur. However, further exploration revealed that systemic absorption from the References 1. Zimmerman, M.: Chronic Penicillin Urticaria from Dairy Products Proved by Penicillinase Cures , A.M.A. Arch. Derm. 79:1, 1959.Crossref 2. Siegel, B. B.: Hidden Contacts with Penicillin , Bull. W.H.O. 21:703, 1959. 3. Grossman, L. I.: Root Canal Therapy , Philadelphia, Lea & Febiger, 1955.

Journal

Archives of DermatologyAmerican Medical Association

Published: Mar 1, 1963

References