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A Contribution to the Chemotherapy of Bacterial Infections

A Contribution to the Chemotherapy of Bacterial Infections Abstract Hitherto it has been thought that only protozoan infections could be attacked chemotherapeutically. In the field of protozoan infections we do possess specific drugs, such as Germanin for Trypanosomal infections, Neostibosan for Kala-Azar, Plasmochin and Atabrine for malaria, and Salvarsan and its derivatives for spirochetal infections, especially syphilis. Even moderately effective chemotherapy against coccal infections was heretofore unknown. Protozoa and spirochetes represent relatively well differentiated forms of life; and the more highly developed the infectious agent the more vulnerable to chemotherapeutic attack it appears to be. Morgenroth has made a beginning in the chemotherapy of pneumococcal infections, yet Optochin is effective only when directly applied to the infected area, as is the case with Vuzin—another hydrochinin derivative—in streptococcal infections. In the case of generalized infections, we have not seen clearly recognizable effects in our experimental animals with these preparations. Furthermore, the silver compounds recommended for the treatment of sepsis References 1. Eisenberg: Zentralblatt für Bakteriologie , vol 71, 1913. 2. Feldt: Klinische Wochenschrift , vol 5, page 299, 1926Crossref 3. and vol 11, page 1378, 1932. 4. Lockemann and Ulrich: Deutsche Medizinische Wochenschrift , page 395, 1934. 5. Ostromislensky: Journal of the American Chemical Society , vol 56, page 1713, 1934.Crossref 6. Schiemann and Feldt: Zentralblatt für Hygiene , vol 106, page 83, 1926.Crossref 7. Tschitschibabin and Seide : Journal of the Russian Physiological-Chemical Society , (as quoted in Chemisches Zentralblatt, vol 1, page 1064, 1915). 8. Warner: Medizinische Welt , vol 39, page 1398, 1930. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png American Journal of Diseases of Children American Medical Association

A Contribution to the Chemotherapy of Bacterial Infections

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Publisher
American Medical Association
Copyright
Copyright © 1970 American Medical Association. All Rights Reserved.
ISSN
0002-922X
DOI
10.1001/archpedi.1970.02100050010004
Publisher site
See Article on Publisher Site

Abstract

Abstract Hitherto it has been thought that only protozoan infections could be attacked chemotherapeutically. In the field of protozoan infections we do possess specific drugs, such as Germanin for Trypanosomal infections, Neostibosan for Kala-Azar, Plasmochin and Atabrine for malaria, and Salvarsan and its derivatives for spirochetal infections, especially syphilis. Even moderately effective chemotherapy against coccal infections was heretofore unknown. Protozoa and spirochetes represent relatively well differentiated forms of life; and the more highly developed the infectious agent the more vulnerable to chemotherapeutic attack it appears to be. Morgenroth has made a beginning in the chemotherapy of pneumococcal infections, yet Optochin is effective only when directly applied to the infected area, as is the case with Vuzin—another hydrochinin derivative—in streptococcal infections. In the case of generalized infections, we have not seen clearly recognizable effects in our experimental animals with these preparations. Furthermore, the silver compounds recommended for the treatment of sepsis References 1. Eisenberg: Zentralblatt für Bakteriologie , vol 71, 1913. 2. Feldt: Klinische Wochenschrift , vol 5, page 299, 1926Crossref 3. and vol 11, page 1378, 1932. 4. Lockemann and Ulrich: Deutsche Medizinische Wochenschrift , page 395, 1934. 5. Ostromislensky: Journal of the American Chemical Society , vol 56, page 1713, 1934.Crossref 6. Schiemann and Feldt: Zentralblatt für Hygiene , vol 106, page 83, 1926.Crossref 7. Tschitschibabin and Seide : Journal of the Russian Physiological-Chemical Society , (as quoted in Chemisches Zentralblatt, vol 1, page 1064, 1915). 8. Warner: Medizinische Welt , vol 39, page 1398, 1930.

Journal

American Journal of Diseases of ChildrenAmerican Medical Association

Published: Jan 1, 1970

References