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A Comparative Study of the Ototoxicity of Tobramycin and Gentamicin

A Comparative Study of the Ototoxicity of Tobramycin and Gentamicin Abstract Dose response experiments were conducted on guinea pigs comparing the toxic liability of tobramycin and gentamicin on cochlear electrophysiology and histology. Parallel curves were obtained for the effect on the alternating current cochlear potential and hair cell destruction. In all cases the most damaging effect was produced by gentamicin. References 1. Brummett RE, Meikle MB, Vernon JA: Ototoxicity of tobramycin in guinea pigs . Arch Otolaryng 94:59-63, 1971.Crossref 2. Wick WE, Welles JS: Nebramycin, a new broad-spectrum antibiotic complex IV in vitro and in vivo laboratory evaluation , in Antimicrobial Agents and Chemotherapy . Ann Arbor, Mich, American Society for Microbiology, 1967, pp 341-348. 3. Hawkins TE, Johnsson L, Aran J: Comparative tests of gentamicin ototoxicity . J Infect Dis 119:417-426, 1969.Crossref 4. Meyers RM: Ototoxic effects of gentamicin . Arch Otolaryng 92:160-162, 1970.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Otolaryngology American Medical Association

A Comparative Study of the Ototoxicity of Tobramycin and Gentamicin

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Publisher
American Medical Association
Copyright
Copyright © 1972 American Medical Association. All Rights Reserved.
ISSN
0003-9977
DOI
10.1001/archotol.1972.00770090783003
Publisher site
See Article on Publisher Site

Abstract

Abstract Dose response experiments were conducted on guinea pigs comparing the toxic liability of tobramycin and gentamicin on cochlear electrophysiology and histology. Parallel curves were obtained for the effect on the alternating current cochlear potential and hair cell destruction. In all cases the most damaging effect was produced by gentamicin. References 1. Brummett RE, Meikle MB, Vernon JA: Ototoxicity of tobramycin in guinea pigs . Arch Otolaryng 94:59-63, 1971.Crossref 2. Wick WE, Welles JS: Nebramycin, a new broad-spectrum antibiotic complex IV in vitro and in vivo laboratory evaluation , in Antimicrobial Agents and Chemotherapy . Ann Arbor, Mich, American Society for Microbiology, 1967, pp 341-348. 3. Hawkins TE, Johnsson L, Aran J: Comparative tests of gentamicin ototoxicity . J Infect Dis 119:417-426, 1969.Crossref 4. Meyers RM: Ototoxic effects of gentamicin . Arch Otolaryng 92:160-162, 1970.Crossref

Journal

Archives of OtolaryngologyAmerican Medical Association

Published: Dec 1, 1972

References