Abstract Almost a century after Little1 described the clinical syndrome now classified under the general term "cerebral palsy" the problem of etiology in a large number of cases remains enigmatic. This is complicated by the fact that cerebral palsy is not a distinct pathological or clinical entity and may result from numerous causes operating in the prenatal, natal, or postnatal periods of development, affecting different parts of the central nervous system and giving rise to different types and varying degrees of involvement. Our approach to the study of the hereditary aspect of cerebral palsy was to collect family histories at the Moody State School for Cerebral Palsied Children with special reference to families with more than one cerebral palsied child. In the course of this investigation a family group with two (Fig. 1) affected children, a boy (Fig. 2a) and a girl (Fig. 2b), came to our attention. References 1. Little, W. J.: On the Influence of Abnormal Parturition, Difficult, Premature Birth, and Asphyxia Neonatorum on the Mental and Physical Condition of the Child, Especially in Relation to Deformities , Lancet 2:378 ( (Oct. 19) ) 1861. 2. Gregg, N. M.: Congenital Cataract Following German Measles in Mother , Tr. Ophth. Soc. Australia (1941) 3:35, 1942. 3. Mann, I.: Developmental Abnormalities of the Eye , Ed. 2, Philadelphia and Montreal, J. B. Lippincott Company, 1957. 4. Blumel, J.: Genetic Factors Pertaining to the Etiology of Cerebral Palsy , Texas J. Med. 54:248 ( (April) ) 1958. 5. Blumel, J.; Evans, E. B., and Eggers, G. W. N.: Hereditary Cerebral Palsy: A Preliminary Report , J. Pediat. 50:454 ( (April) ) 1957.Crossref 6. Sjögren, T.: Hereditary Congenital Spinocerebellar Ataxia Combined with Congenital Cataract and Oligophrenia , Acta psychiat. et neurol. Suppl. 46:286, 1947.Crossref 7. Sjögren, T.: Klinische und vererbungsmedizinische Untersuchungen über Oligophrenie mit kongenitaler Katarakt , Ztschr. ges. Neurol. u. Psychiat. 152:263, 1935.Crossref 8. Guibor, G.: Spasmus Fixus with Cerebral Palsy: A Case Report , Am. J. Ophth. 36:1719 ( (Dec.) ) 1953. 9. Guibor, G.: Some Eye Defects Seen in Cerebral Palsy with Some Statistics , Am. J. Phys. Med. 32:342 ( (Dec.) ) 1953. 10. Breakey, A. S.: Ocular Findings in Cerebral Palsy , A.M.A. Arch. Ophth. 53:852 ( (June) ) 1955.Crossref 11. Yannet, H.: The Etiology of Congenital Cerebral Palsy: A Statistical and Clinical Study , J. Pediat. 24:38 ( (Jan.) ) 1944.Crossref 12. Schachat, W. S.; Wallace, H. M.; Palmer, M., and Slater, B.: Ophthalmologic Findings in Children with Cerebral Palsy , Pediatrics 19:623 (April, (Pt. 1) ) 1957. 13. Minear, W. L.: A Classification of Cerebral Palsy , Pediatrics 18:841 ( (Nov.) ) 1956.
A.M.A. Archives of Ophthalmology – American Medical Association
Published: Feb 1, 1960
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