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A Clinical Comparison Study of the Effects of Reserpine and Placebo on Anxiety

A Clinical Comparison Study of the Effects of Reserpine and Placebo on Anxiety Abstract Within recent years considerable attention has been directed toward the therapeutic effects of reserpine (alkaloid of Rauwolfia serpentina) on a large variety of emotional disorders, and many favorable reports have appeared in both medical and lay publications. Noce et al.,1,2 Barsa and Kline,3 Kline and Stanley,4 and Hollister et al.5 were among the first to report on its effects on mentally ill patients. These studies were limited to hospitalized patients who manifested psychotic disorders of varying duration, type, and degree. More recently, Hare, Seager, and Leitch6 reported a study of the effects of reserpine as compared with those of amobarbital and of an inert control substance on 42 neurotic inpatients. These authors concluded that amobarbital produced much improvement in a great majority of their patients, whereas the results with reserpine were no better than those with the placebo. They suggested the need for caution in References 1. State of Illinois, Mental Health Centers, 2449 W. Washington Blvd., Chicago 12. 2. Noce, R. H.; Williams, D. B., and Rapaport, W.: Reserpine (Serpasil) in the Management of the Mentally Ill and Mentally Retarded: Preliminary Report , J. A. M. A. 156:821-824 ( (Oct. 30) ) 1954.Crossref 3. Noce, R. H.; Williams, D. B., and Rapaport, W.: Reserpine (Serpasil) in the Management of the Mentally Ill , J. A. M. A. 158:11-15 ( (May 7) ) 1955.Crossref 4. Barsa, J. A., and Kline, N. S.: Treatment of 200 Disturbed Psychotics with Reserpine, J. A. M. A. 158:110-113 ( (May 14) ) 1955.Crossref 5. Kline, N. S., and Stanley, A. M.: Use of Reserpine in a Neuropsychiatric Hospital , Ann. New York Acad. Sc. 61:85-91 ( (April 15) ) 1955.Crossref 6. Hollister, L. E.; Krieger, G. E.; Kringel, A., and Roberts, R. H.: Treatment of Chronic Schizophrenic Reactions with Reserpine , Ann. New York Acad. Sc. 61:92-100 ( (April 15) ) 1955.Crossref 7. Hare, E. H.; Seager, C. P., and Leitch, A.: Reserpine in Anxiety States , Lancet 1:545-547 ( (April 28) ) 1956.Crossref 8. Davies, D. L., and Shepherd, M.: Reserpine in the Treatment of Anxious and Depressed Patients Lancet 2:117-120 ( (July 16) ) 1955.Crossref 9. Freis, E. D.: Mental Depression in Hypertensive Patients Treated for Long Periods with Large Doses of Reserpine , New England J. Med. 251:1006-1008 ( (Dec. 16) ) 1954.Crossref 10. Folkson, A., and May, A. R.: Use of Reserpine Rauwolfia in Psychoneuroses , Brit. M. J. 2:1121-1122 ( (Nov. 5) ) 1955.Crossref 11. Drake, F. R., and Ebaugh, F. G.: The Use of Reserpine in Office Psychiatry: Preliminary Report , Ann. New York Acad. Sc. 61:198-205 ( (April 15) ) 1955.Crossref 12. Wolf, S., and Pinsky, R. H.: Effects of Placebo Administration and Occurrence of Toxic Reactions , J. A. M. A. 155:339-341 ( (May 22) ) 1954.Crossref 13. Freis, E. D., and Ari, R.: Clinical and Experimental Effects of Reserpine in Patients with Essential Hypertension , Ann. New York Acad. Sc. 59:45-53 ( (April 30) ) 1954.Crossref 14. Feldman, P. E.: The Personal Element in Psychiatric Research , Am. J. Psychiat. 113:52-54 ( (July) ) 1956. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png A.M.A. Archives of Neurology & Psychiatry American Medical Association

A Clinical Comparison Study of the Effects of Reserpine and Placebo on Anxiety

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Publisher
American Medical Association
Copyright
Copyright © 1959 American Medical Association. All Rights Reserved.
ISSN
0096-6886
DOI
10.1001/archneurpsyc.1959.02340150124016
Publisher site
See Article on Publisher Site

Abstract

Abstract Within recent years considerable attention has been directed toward the therapeutic effects of reserpine (alkaloid of Rauwolfia serpentina) on a large variety of emotional disorders, and many favorable reports have appeared in both medical and lay publications. Noce et al.,1,2 Barsa and Kline,3 Kline and Stanley,4 and Hollister et al.5 were among the first to report on its effects on mentally ill patients. These studies were limited to hospitalized patients who manifested psychotic disorders of varying duration, type, and degree. More recently, Hare, Seager, and Leitch6 reported a study of the effects of reserpine as compared with those of amobarbital and of an inert control substance on 42 neurotic inpatients. These authors concluded that amobarbital produced much improvement in a great majority of their patients, whereas the results with reserpine were no better than those with the placebo. They suggested the need for caution in References 1. State of Illinois, Mental Health Centers, 2449 W. Washington Blvd., Chicago 12. 2. Noce, R. H.; Williams, D. B., and Rapaport, W.: Reserpine (Serpasil) in the Management of the Mentally Ill and Mentally Retarded: Preliminary Report , J. A. M. A. 156:821-824 ( (Oct. 30) ) 1954.Crossref 3. Noce, R. H.; Williams, D. B., and Rapaport, W.: Reserpine (Serpasil) in the Management of the Mentally Ill , J. A. M. A. 158:11-15 ( (May 7) ) 1955.Crossref 4. Barsa, J. A., and Kline, N. S.: Treatment of 200 Disturbed Psychotics with Reserpine, J. A. M. A. 158:110-113 ( (May 14) ) 1955.Crossref 5. Kline, N. S., and Stanley, A. M.: Use of Reserpine in a Neuropsychiatric Hospital , Ann. New York Acad. Sc. 61:85-91 ( (April 15) ) 1955.Crossref 6. Hollister, L. E.; Krieger, G. E.; Kringel, A., and Roberts, R. H.: Treatment of Chronic Schizophrenic Reactions with Reserpine , Ann. New York Acad. Sc. 61:92-100 ( (April 15) ) 1955.Crossref 7. Hare, E. H.; Seager, C. P., and Leitch, A.: Reserpine in Anxiety States , Lancet 1:545-547 ( (April 28) ) 1956.Crossref 8. Davies, D. L., and Shepherd, M.: Reserpine in the Treatment of Anxious and Depressed Patients Lancet 2:117-120 ( (July 16) ) 1955.Crossref 9. Freis, E. D.: Mental Depression in Hypertensive Patients Treated for Long Periods with Large Doses of Reserpine , New England J. Med. 251:1006-1008 ( (Dec. 16) ) 1954.Crossref 10. Folkson, A., and May, A. R.: Use of Reserpine Rauwolfia in Psychoneuroses , Brit. M. J. 2:1121-1122 ( (Nov. 5) ) 1955.Crossref 11. Drake, F. R., and Ebaugh, F. G.: The Use of Reserpine in Office Psychiatry: Preliminary Report , Ann. New York Acad. Sc. 61:198-205 ( (April 15) ) 1955.Crossref 12. Wolf, S., and Pinsky, R. H.: Effects of Placebo Administration and Occurrence of Toxic Reactions , J. A. M. A. 155:339-341 ( (May 22) ) 1954.Crossref 13. Freis, E. D., and Ari, R.: Clinical and Experimental Effects of Reserpine in Patients with Essential Hypertension , Ann. New York Acad. Sc. 59:45-53 ( (April 30) ) 1954.Crossref 14. Feldman, P. E.: The Personal Element in Psychiatric Research , Am. J. Psychiat. 113:52-54 ( (July) ) 1956.

Journal

A.M.A. Archives of Neurology & PsychiatryAmerican Medical Association

Published: Mar 1, 1959

References

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