A Clinical Comparison Study of the Effects of Reserpine and Placebo on Anxiety
A Clinical Comparison Study of the Effects of Reserpine and Placebo on Anxiety
SEGAL, MOREY M.;SHAPIRO, KIEVE L.
1959-03-01 00:00:00
Abstract Within recent years considerable attention has been directed toward the therapeutic effects of reserpine (alkaloid of Rauwolfia serpentina) on a large variety of emotional disorders, and many favorable reports have appeared in both medical and lay publications. Noce et al.,1,2 Barsa and Kline,3 Kline and Stanley,4 and Hollister et al.5 were among the first to report on its effects on mentally ill patients. These studies were limited to hospitalized patients who manifested psychotic disorders of varying duration, type, and degree. More recently, Hare, Seager, and Leitch6 reported a study of the effects of reserpine as compared with those of amobarbital and of an inert control substance on 42 neurotic inpatients. These authors concluded that amobarbital produced much improvement in a great majority of their patients, whereas the results with reserpine were no better than those with the placebo. They suggested the need for caution in References 1. State of Illinois, Mental Health Centers, 2449 W. Washington Blvd., Chicago 12. 2. Noce, R. H.; Williams, D. B., and Rapaport, W.: Reserpine (Serpasil) in the Management of the Mentally Ill and Mentally Retarded: Preliminary Report , J. A. M. A. 156:821-824 ( (Oct. 30) ) 1954.Crossref 3. Noce, R. H.; Williams, D. B., and Rapaport, W.: Reserpine (Serpasil) in the Management of the Mentally Ill , J. A. M. A. 158:11-15 ( (May 7) ) 1955.Crossref 4. Barsa, J. A., and Kline, N. S.: Treatment of 200 Disturbed Psychotics with Reserpine, J. A. M. A. 158:110-113 ( (May 14) ) 1955.Crossref 5. Kline, N. S., and Stanley, A. M.: Use of Reserpine in a Neuropsychiatric Hospital , Ann. New York Acad. Sc. 61:85-91 ( (April 15) ) 1955.Crossref 6. Hollister, L. E.; Krieger, G. E.; Kringel, A., and Roberts, R. H.: Treatment of Chronic Schizophrenic Reactions with Reserpine , Ann. New York Acad. Sc. 61:92-100 ( (April 15) ) 1955.Crossref 7. Hare, E. H.; Seager, C. P., and Leitch, A.: Reserpine in Anxiety States , Lancet 1:545-547 ( (April 28) ) 1956.Crossref 8. Davies, D. L., and Shepherd, M.: Reserpine in the Treatment of Anxious and Depressed Patients Lancet 2:117-120 ( (July 16) ) 1955.Crossref 9. Freis, E. D.: Mental Depression in Hypertensive Patients Treated for Long Periods with Large Doses of Reserpine , New England J. Med. 251:1006-1008 ( (Dec. 16) ) 1954.Crossref 10. Folkson, A., and May, A. R.: Use of Reserpine Rauwolfia in Psychoneuroses , Brit. M. J. 2:1121-1122 ( (Nov. 5) ) 1955.Crossref 11. Drake, F. R., and Ebaugh, F. G.: The Use of Reserpine in Office Psychiatry: Preliminary Report , Ann. New York Acad. Sc. 61:198-205 ( (April 15) ) 1955.Crossref 12. Wolf, S., and Pinsky, R. H.: Effects of Placebo Administration and Occurrence of Toxic Reactions , J. A. M. A. 155:339-341 ( (May 22) ) 1954.Crossref 13. Freis, E. D., and Ari, R.: Clinical and Experimental Effects of Reserpine in Patients with Essential Hypertension , Ann. New York Acad. Sc. 59:45-53 ( (April 30) ) 1954.Crossref 14. Feldman, P. E.: The Personal Element in Psychiatric Research , Am. J. Psychiat. 113:52-54 ( (July) ) 1956.
http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.pngA.M.A. Archives of Neurology & PsychiatryAmerican Medical Associationhttp://www.deepdyve.com/lp/american-medical-association/a-clinical-comparison-study-of-the-effects-of-reserpine-and-placebo-on-Iq5RZg2emR
A Clinical Comparison Study of the Effects of Reserpine and Placebo on Anxiety
Abstract Within recent years considerable attention has been directed toward the therapeutic effects of reserpine (alkaloid of Rauwolfia serpentina) on a large variety of emotional disorders, and many favorable reports have appeared in both medical and lay publications. Noce et al.,1,2 Barsa and Kline,3 Kline and Stanley,4 and Hollister et al.5 were among the first to report on its effects on mentally ill patients. These studies were limited to hospitalized patients who manifested psychotic disorders of varying duration, type, and degree. More recently, Hare, Seager, and Leitch6 reported a study of the effects of reserpine as compared with those of amobarbital and of an inert control substance on 42 neurotic inpatients. These authors concluded that amobarbital produced much improvement in a great majority of their patients, whereas the results with reserpine were no better than those with the placebo. They suggested the need for caution in References 1. State of Illinois, Mental Health Centers, 2449 W. Washington Blvd., Chicago 12. 2. Noce, R. H.; Williams, D. B., and Rapaport, W.: Reserpine (Serpasil) in the Management of the Mentally Ill and Mentally Retarded: Preliminary Report , J. A. M. A. 156:821-824 ( (Oct. 30) ) 1954.Crossref 3. Noce, R. H.; Williams, D. B., and Rapaport, W.: Reserpine (Serpasil) in the Management of the Mentally Ill , J. A. M. A. 158:11-15 ( (May 7) ) 1955.Crossref 4. Barsa, J. A., and Kline, N. S.: Treatment of 200 Disturbed Psychotics with Reserpine, J. A. M. A. 158:110-113 ( (May 14) ) 1955.Crossref 5. Kline, N. S., and Stanley, A. M.: Use of Reserpine in a Neuropsychiatric Hospital , Ann. New York Acad. Sc. 61:85-91 ( (April 15) ) 1955.Crossref 6. Hollister, L. E.; Krieger, G. E.; Kringel, A., and Roberts, R. H.: Treatment of Chronic Schizophrenic Reactions with Reserpine , Ann. New York Acad. Sc. 61:92-100 ( (April 15) ) 1955.Crossref 7. Hare, E. H.; Seager, C. P., and Leitch, A.: Reserpine in Anxiety States , Lancet 1:545-547 ( (April 28) ) 1956.Crossref 8. Davies, D. L., and Shepherd, M.: Reserpine in the Treatment of Anxious and Depressed Patients Lancet 2:117-120 ( (July 16) ) 1955.Crossref 9. Freis, E. D.: Mental Depression in Hypertensive Patients Treated for Long Periods with Large Doses of Reserpine , New England J. Med. 251:1006-1008 ( (Dec. 16) ) 1954.Crossref 10. Folkson, A., and May, A. R.: Use of Reserpine Rauwolfia in Psychoneuroses , Brit. M. J. 2:1121-1122 ( (Nov. 5) ) 1955.Crossref 11. Drake, F. R., and Ebaugh, F. G.: The Use of Reserpine in Office Psychiatry: Preliminary Report , Ann. New York Acad. Sc. 61:198-205 ( (April 15) ) 1955.Crossref 12. Wolf, S., and Pinsky, R. H.: Effects of Placebo Administration and Occurrence of Toxic Reactions , J. A. M. A. 155:339-341 ( (May 22) ) 1954.Crossref 13. Freis, E. D., and Ari, R.: Clinical and Experimental Effects of Reserpine in Patients with Essential Hypertension , Ann. New York Acad. Sc. 59:45-53 ( (April 30) ) 1954.Crossref 14. Feldman, P. E.: The Personal Element in Psychiatric Research , Am. J. Psychiat. 113:52-54 ( (July) ) 1956.
Journal
A.M.A. Archives of Neurology & Psychiatry
– American Medical Association
Published: Mar 1, 1959
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References
Reserpine (Serpasil) in the Management of the Mentally Ill and Mentally Retarded: Preliminary Report
Noce , R. H.; Williams, D. B., and Rapaport, W.
Reserpine (Serpasil) in the Management of the Mentally Ill
Noce , R. H.; Williams, D. B., and Rapaport, W.
Treatment of 200 Disturbed Psychotics with Reserpine,
Barsa , J. A., and Kline, N. S.
Use of Reserpine in a Neuropsychiatric Hospital
Kline , N. S., and Stanley, A. M.
Treatment of Chronic Schizophrenic Reactions with Reserpine
Hollister , L. E.; Krieger, G. E.; Kringel, A., and Roberts, R. H.
Reserpine in Anxiety States
Hare , E. H.; Seager, C. P., and Leitch, A.
Reserpine in the Treatment of Anxious and Depressed Patients
Davies , D. L., and Shepherd, M.
Mental Depression in Hypertensive Patients Treated for Long Periods with Large Doses of Reserpine
Freis , E. D.
Use of Reserpine Rauwolfia in Psychoneuroses
Folkson , A., and May, A. R.
The Use of Reserpine in Office Psychiatry: Preliminary Report
Drake , F. R., and Ebaugh, F. G.
Effects of Placebo Administration and Occurrence of Toxic Reactions
Wolf , S., and Pinsky, R. H.
Clinical and Experimental Effects of Reserpine in Patients with Essential Hypertension
Freis , E. D., and Ari, R.
The Personal Element in Psychiatric Research
Feldman , P. E.
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