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V. Dubowitz, K. Rogers (1969)
5‐Hydroxyindoles in the Cerebrospinal Fluid of Infants with Down's Syndrome and Muscle HypotoniaDevelopmental Medicine & Child Neurology, 11
Bayer SM McCoy EE (1973)
Decreased serotonin uptake and ATPase activity in platelets from Down's syndrome patientsClin Res, 21
Marsh Rw, Cabaret Jj (1972)
Down's syndrome treated with a low phenylalanine diet: case report.The New Zealand Medical Journal, 75
D. Boullin, R. O'brien (1971)
Abnormalities of 5‐hydroxytryptamine uptake and binding by blood platelets from children with Down's syndromeThe Journal of Physiology, 212
Morizon G Aspillaga MJ (1975)
Dimethylsulfoxide therapy in severe retardation in mongoloid childrenAnn NY Acad Sci, 243
J. Berman, J. Berman, P. Justice, P. Justice, D. Hsia, D. Hsia (1965)
The metabolism of 5-hydroxytryptamine (serotonin) in the newborn.The Journal of pediatrics, 67 4
Turkel H (1975)
Medical amelioration of Down's syndrome incorporating the orthomolecular approachJ Orthomol Psychol, 4
Liedholm M Fellstrom P (1973)
Evidence of altered cerebral serotonin metabolism in Down's syndrome from measurements of cerebro-spinal fluid acidsPediatr Res, 7
A. Sjoerdsma, W. Lovenberg, K. Engelman, W. Carpenter, R. Wyatt, G. Gessa (1970)
Serotonin now: clinical implications of inhibiting its synthesis with para-chlorophenylalanine.Annals of internal medicine, 73 4
O. Saxl (1968)
Down's syndrome: new aspects.Acta paediatrica Academiae Scientiarum Hungaricae, 9 3
J. Tu, M. Partington (1972)
5‐Hydroxyindole Levels in the Blood and CSF in Down's Syndrome, Phenylketonuria and Severe Mental RetardationDevelopmental Medicine & Child Neurology, 14
A. Sjoerdsma, H. Weissbach, L. Terry, S. Udenfriend (1957)
Further observations on patients with malignant carcinoid.The American journal of medicine, 23 1
League R Bzoch KR (1970)
The Receptive-Expressive Emergent Language Scale for the Measurement of Language Skills in Infancy
J. Priest (1961)
The Child with MongolismJAMA, 175
M. Aspillaga, G. Morizon, I. Avendaño, M. Sánchez, Lucila Capdeville (1975)
DIMETHYL SULFOXIDE THERAPY IN SEVERE RETARDATION IN MONGOLOID CHILDRENAnnals of the New York Academy of Sciences, 243
Black Db, Kato Jg, Walker Gw (1966)
A STUDY OF IMPROVEMENT IN MENTALLY RETARDED CHILDREN ACCRUING FROM Siccacell therapy.American journal of mental deficiency, 70
Bazelon M (1967)
Serotonin metabolism in Down syndromeClin Proc Child Hosp DC, 23
J. Delâge, C. Bie, R. D'Amboise (1970)
[Vineland's social maturity scale].Laval medical, 41 4
D. O'Brien, A. Groshek (1962)
The Abnormality of Tryptophane Metabolism in Children with MongolismArchives of Disease in Childhood, 37
Cabaret JJ Marsh RW (1971)
Down's syndrome treated with a low phenylalanine diet: Case reportNZ Med J, 75
De la Cruz F (1977)
Research to Practice in Mental Retardation: Education and Training, 3
E. Blumberg (1959)
Two years of pituitary treatment in mongoloids: a clinical study.The Journal of the Maine Medical Association, 50 4
I. Lott, T. Chase, D. Murphy (1972)
Down's Syndrome: Transport, Storage, and Metabolism of Serotonin in Blood PlateletsPediatric Research, 6
Oestreicher P (1973)
Die Behandlung des MongolismusMonatsschr Kinderheilkd, 121
Kamoun P Jerome J (1967)
Diminution du taux de la serotonine associee a un defaut de captation dans les plaquettes sanguines des sujets trisomiques 21CR Acad Sci, 264
M. Partington, M. MacDonald, J. Tu (1971)
5‐Hydroxytryptophan (5‐HTP) in Down's SyndromeDevelopmental Medicine & Child Neurology, 13
D. Glick (1968)
Methods of Biochemical Analysis
Pueschel SM
Proceedings of Conference on Trisomy 21 (Down syndrome)
Mary Bazelon, Mary Bazelon, RichmondS. Paine, RichmondS. Paine, ValerieA. Cowie, ValerieA. Cowie, Patricia Hunt, Patricia Hunt, JohnC. Houck, JohnC. Houck, Dersh Mahanand, Dersh Mahanand (1967)
Reversal of hypotonia in infants with Down's syndrome by administration of 5-hydroxytryptophan.Lancet, 1 7500
Bayley N (1969)
Manual for the Bayley Scales of Infant Development. New York, Psychological Cooperation
S. Pueschel, A. Murphy (1975)
Counseling parents of infants with Down's syndrome.Postgraduate medicine, 58 7
Ong BH Rosner F (1965)
Bloodserotonin activity in trisomic and translocation Down's syndromeLancet, 1
Haus E Schmid F (1972)
Beeinflussung der mongoloiden Dyszephalie durch Injektionsimplantationen fetaler, heterologer GehirngewebeFortschr Med, 90
P. Weise, R. Koch, K. Shaw, M. Rosenfeld (1974)
The use of 5-HTP in the treatment of Down's syndrome.Pediatrics, 54 2
Steinberg L Coleman M (1973)
Serotonin in Down's Syndrome
F. Zimmerman, B. Burgemeister, T. Putman (1949)
Effect of glutamic acid on the intelligence of patients with mongolism.Archives of neurology and psychiatry, 61 3
R. Koch, J. Share, B. Graliker (1965)
THE EFFECTS OF CYTOMEL ON YOUNG CHILDREN WITH DOWN'S SYNDROME (MONGOLISM): A DOUBLE-BLIND LONGITUDINAL STUDY.The Journal of pediatrics, 66
P. Oestreicher (1973)
[Therapy of mongolism].Monatsschrift fur Kinderheilkunde, 121 7
J. Tu, Hans Zellweger (1965)
Blood-serotonin deficiency in Down's syndrome.Lancet, 2 7415
Share JB (1976)
A review of drug treatment for Down syndrome personsAm J Ment Defic, 80
Abstract • In a double-blind study, 89 children with Down's syndrome were given 5-hydroxytryptophan or pyridoxine hydrochloride in the first three years of life. The analysis of 5-hydroxyindole blood levels revealed that 5-hydroxytryptophan, pyridoxine, and the combination of 5-hydroxytryptophan and pyridoxine raised blood levels of 5-hydroxyindole equally well in 40% of the children. The assessment of muscle-tone ratings showed no significant difference among the study groups once children with moderate and severe congenital heart disease were excluded. Detailed studies of cognitive-adaptive function of children in the various groups found a significant difference on the Vineland Social Maturity Scale at ages 6, 12, 18, and 36 months; yet the source of significance was a negative interaction affecting children whose parents were able to comply with furnished guidance; these children showed consistently higher levels of accomplishment. (Am J Dis Child 134:838-844, 1980) References 1. Benda CF: The Child With Mongolism . New York, Grune & Stratton Inc, 1960. 2. Koch R, Share J, Graliker B: The effects of Cytomel on young children with Down's syndrome (mongolism): A double-blind longitudinal study . J Pediatr 66:776-778, 1965.Crossref 3. Zimmerman FT, Burgermeister BB, Putnam TJ: Effect of glutamic acid on the intelligence of patients with mongolism . Arch Neurol Psychiatry 61:275-287, 1949.Crossref 4. Marsh RW, Cabaret JJ: Down's syndrome treated with a low phenylalanine diet: Case report . NZ Med J 75:364-365, 1971. 5. Blumberg E: Two years of pituitary treatment in mongoloids: A clinical study . J Maine Med Assoc 50:120-125, 1959. 6. Aspillaga MJ, Morizon G, Avendano I: Dimethylsulfoxide therapy in severe retardation in mongoloid children . Ann NY Acad Sci 243:421-431, 1975.Crossref 7. Schmid F, Haus E, Moradof S, et al: Beeinflussung der mongoloiden Dyszephalie durch Injektionsimplantationen fetaler, heterologer Gehirngewebe . Fortschr Med 90:1181-1186, 1972. 8. Oestreicher P: Die Behandlung des Mongolismus . Monatsschr Kinderheilkd 121:316-317, 1973. 9. Black DB, Kato JG, Walker GW: A study of improvement in mentally retarded children accruing from sicca cell therapy . Am J Ment Defic 70:499-508, 1966. 10. Turkel H: Medical amelioration of Down's syndrome incorporating the orthomolecular approach . J Orthomol Psychol 4:102-115, 1975. 11. Share JB: A review of drug treatment for Down syndrome persons . Am J Ment Defic 80:388-393, 1976. 12. De la Cruz F: Medical management of mongolism or Down syndrome , in Mittler P (ed): Research to Practice in Mental Retardation: Education and Training . Baltimore, University Park Press, 1977, vol 3. 13. Pueschel SM: Therapeutic approaches in Down syndrome , in Proceedings of Conference on Trisomy 21 (Down syndrome) . Baltimore, University Park Press, to be published. 14. Rosner F, Ong BH, Paine RS, et al: Bloodserotonin activity in trisomic and translocation Down's syndrome . Lancet 1:1191-1193, 1965.Crossref 15. Tu J, Zellweger H: Blood serotonin deficiency in Down's syndrome . Lancet 2:715-716, 1965.Crossref 16. Berman JL, Justice P, Hsia DY: The metabolism of 5-hydroxytryptamine (serotonin) in the newborn . J Pediatr 67:603-608, 1965.Crossref 17. Saxl O: Down's syndrome: New aspects . Acta Paediatr Acad Sci Hung 9:329-336, 1968. 18. Bazelon M: Serotonin metabolism in Down syndrome . Clin Proc Child Hosp DC 23:58-63, 1967. 19. Carpenter WT: Serotonin now: Clinical implications of inhibiting its synthesis with p-chlorophenylalanine . Ann Intern Med 73:607-629, 1970.Crossref 20. Bazelon M, Paine RS, Cowie VA, et al: Reversal of hypotonia in infants with Down's syndrome by administration of 5-hydroxytryptophan . Lancet 1:1130-1133, 1967.Crossref 21. Coleman M, Steinberg L: A double-blind trial of 5-hydroxytryptophan in trisomy 21 patients , in Coleman M (ed): Serotonin in Down's Syndrome . New York, American Elsevier Publishing Co Inc, 1973. 22. Partington MW, MacDonald MRA, Tu JB: 5-Hydroxytryptophan (5-HTP) in Down's syndrome . Develop Med Child Neurol 13:362-372, 1971.Crossref 23. Weise P, Koch R, Shaw KNF, et al: The use of 5-HTP in the treatment of Down's syndrome . Pediatrics 54:165-168, 1974. 24. Udenfriend S, Weissbach H, Brodie BB, in Glick D (ed): Methods of Biochemical Analysis . New York, Wiley-Interscience, 1958, vol 6. 25. Sjoerdsma A, Weissbach H, Terry LL, et al: Further observations on patients with malignant carcinosis . Am J Med 23:5-15, 1957.Crossref 26. Bayley N: Manual for the Bayley Scales of Infant Development. New York, Psychological Cooperation , 1969. 27. Doll EA: Vineland Social Maturity Scale . Circle Pines, Minn, American Guidance Service Inc, 1965. 28. Bzoch KR, League R: The Receptive-Expressive Emergent Language Scale for the Measurement of Language Skills in Infancy . Gainesville, Fla, The Tree of Life Press, 1970. 29. Pueschel SM, Murphy A: Counseling of parents of infants with Down's syndrome . Postgrad Med 58:90-95, 1975. 30. O'Brien D, Groshek A: The abnormality of tryptophan metabolism in children with mongolism . Arch Dis Child 37:17-20, 1962.Crossref 31. Jerome J, Kamoun P: Diminution du taux de la serotonine associee a un defaut de captation dans les plaquettes sanguines des sujets trisomiques 21 . CR Acad Sci 264:2072-2075, 1967. 32. Boullin DJ, O'Brien RA: Abnormalities of 5-hydroxytryptamine uptake and binding by blood platelets from children with Down's syndrome . J Physiol 212:287-297, 1971. 33. McCoy EE, Bayer SM: Decreased serotonin uptake and ATPase activity in platelets from Down's syndrome patients . Clin Res 21:304, 1973. 34. Lott IT, Chase TN, Murphy DL: Down's syndrome: Transport, storage and metabolism of serotonin in blood platelets . Pediatr Res 6:730-735, 1972. 35. Dubowitz V, Rogers KJ: 5-Hydroxyindole in the cerebrospinal fluid of infants with Down's syndrome and muscle hypotonia . Develop Med Child Neurol 11:730-734, 1969.Crossref 36. Tu J, Partington MW: 5-Hydroxyindol levels in the blood and CSF in Down's syndrome, phenylketonuria and severe mental retardation . Develop Med Child Neurol 14:457-466, 1972.Crossref 37. Fellstrom P, Liedholm M, Lundborg P: Evidence of altered cerebral serotonin metabolism in Down's syndrome from measurements of cerebro-spinal fluid acids . Pediatr Res 7:53, 1973.Crossref
American Journal of Diseases of Children – American Medical Association
Published: Sep 1, 1980
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