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45, X Chromosome Abnormality in the Offspring of a Narcotic Addict

45, X Chromosome Abnormality in the Offspring of a Narcotic Addict Abstract During a cytogenetic investigation of adult narcotic addicts and their newborn offspring, a female infant with a 45,X karyotype was born to a woman who used heroin and cocaine. The baby had multiple features consistent with the Turner's syndrome phenotype, with the additional findings of bilaterally absent fifth toes. This infant was one of 30 offspring of drug addicts, and while this case might represent a fortuitous circumstance, the possibility of increased incidence of newborn chromosomal aberration with parental drug addiction must be considered. References 1. Kushnick T, Robinson M, Tsao C: Narcotic addicts and their newborns. J Med Soc NJ, to be published. 2. Hsu LY, Strauss L, Hirschhorn K: Chromosome abnormality in offspring of LSD user: D trisomy with translocation . JAMA 211:987-990, 1970.Crossref 3. Bogdanoff B, Rorke LB, Yanoff M, et al: Brain and eye abnormalities . Am J Dis Child 123:145-148, 1972.Crossref 4. Dumars KW Jr: Parental drug usage: Effect upon chromosomes of progeny . Pediatrics 47:1037- 1041, 1971. 5. Berlin CM, Jacobson CB: Discussion of congenital anomalies associated with parental LSD ingestion , in Abstracts of 80th American Pediatric/Society for Pediatric Research Annual Meeting , 1970, p 13. 6. Cohen M, Hirschhorn K, Frosch WA: In vivo and in vitro chromosome damage induced by LSD-25 . N Engl J Med 277:1043-1049, 1967.Crossref 7. Polani PE: Origin of sex chromosome monosomy in man . J Med Genet 8:501-503, 1971.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png American Journal of Diseases of Children American Medical Association

45, X Chromosome Abnormality in the Offspring of a Narcotic Addict

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Publisher
American Medical Association
Copyright
Copyright © 1972 American Medical Association. All Rights Reserved.
ISSN
0002-922X
DOI
10.1001/archpedi.1972.02110170150026
Publisher site
See Article on Publisher Site

Abstract

Abstract During a cytogenetic investigation of adult narcotic addicts and their newborn offspring, a female infant with a 45,X karyotype was born to a woman who used heroin and cocaine. The baby had multiple features consistent with the Turner's syndrome phenotype, with the additional findings of bilaterally absent fifth toes. This infant was one of 30 offspring of drug addicts, and while this case might represent a fortuitous circumstance, the possibility of increased incidence of newborn chromosomal aberration with parental drug addiction must be considered. References 1. Kushnick T, Robinson M, Tsao C: Narcotic addicts and their newborns. J Med Soc NJ, to be published. 2. Hsu LY, Strauss L, Hirschhorn K: Chromosome abnormality in offspring of LSD user: D trisomy with translocation . JAMA 211:987-990, 1970.Crossref 3. Bogdanoff B, Rorke LB, Yanoff M, et al: Brain and eye abnormalities . Am J Dis Child 123:145-148, 1972.Crossref 4. Dumars KW Jr: Parental drug usage: Effect upon chromosomes of progeny . Pediatrics 47:1037- 1041, 1971. 5. Berlin CM, Jacobson CB: Discussion of congenital anomalies associated with parental LSD ingestion , in Abstracts of 80th American Pediatric/Society for Pediatric Research Annual Meeting , 1970, p 13. 6. Cohen M, Hirschhorn K, Frosch WA: In vivo and in vitro chromosome damage induced by LSD-25 . N Engl J Med 277:1043-1049, 1967.Crossref 7. Polani PE: Origin of sex chromosome monosomy in man . J Med Genet 8:501-503, 1971.Crossref

Journal

American Journal of Diseases of ChildrenAmerican Medical Association

Published: Nov 1, 1972

References