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25-Hydroxycholecalciferol for Early Neonatal Hypocalcemia: Occurrence in Premature Newborns

25-Hydroxycholecalciferol for Early Neonatal Hypocalcemia: Occurrence in Premature Newborns Abstract • Oral 25-hydroxycholecalciferol (250HD3) has been used to prevent early neonatal hypocalcemia. Thirty premature neonates were studied prospectively from birth: 22 premature infants constituted a control group, and eight were treated orally with 250HD3 (2 μg/kg/day) for five days beginning within the first 12 hours of life. Eleven of the 22 premature infants in the control group became hypocalcemic, with serum ionized calcium (Ca++) level less than 3.0 mg/dl and total calcium (CaT) level less than 7.0 mg/dl on day 2 of life. Only one of the eight premature infants treated with 250HD3 became hypocalcemic. In treated neonates, serum 25-hydroxyvitamin D, as well as serum Ca and CaT levels, increased during the first five days of life and were considerably greater than levels in control neonates. No untoward effects of this treatment were observed. (Am J Dis Child 132:973-977, 1978) References 1. David L, Anast CS: Calcium metabolism in newborn infants . J Clin Invest 54:287-296, 1974.Crossref 2. Tsang RC, Chen IW, Friedman MA, et al: Neonatal parathyroid function: Role of gestational age and postnatal age . J Pediatr 83:728-737, 1973.Crossref 3. Linarelli LG, Bobik J, Bobik C: Newborn urinary cyclic AMP and developmental renal responsiveness to parathyroid hormone . Pediatrics 50:14-23, 1972. 4. Dirksen C, Anast CS: Hypercalcitoninemia and neonatal hypocalcemia , abstracted. Pediatr Res 11:424, 1977.Crossref 5. Hillman LS, Rojanasathit S, Slatopolsky E, et al: Serial measurements of serum calcium, magnesium, parathyroid hormone, calcitonin, and 25-hydroxy-vitamin D in premature and term infants during the first week of life . Pediatr Res 11:739-744, 1977.Crossref 6. Rosen JF, Roginsky M, Nathenson G, et al: 25-hydroxyvitamin D: Plasma levels in mothers and their premature infants with neonatal hypocalcemia . Am J Dis Child 127:220-223, 1974.Crossref 7. Fleischman AR, Rosen JF, Moses ME: Prevention of early neonatal hypocalcemia with 25-hydroxycholecalciferol , abstracted. Pediatr Res 11:513, 1977.Crossref 8. Chan GM, Tsang RC, Chen IW, et al: Biochemical response to 1,25(OH)2 vitamin D supplementation in premature infants: A prospective study , in Norman AW, Schaefer K, Coburn JW, et al (eds): Vitamin D Biochemical, Chemical and Clinical Aspects Related to Calcium Metabolism . New York, Walter de Gruyter, 1977, pp 569-571. 9. Tsang RC, Light IJ, Sutherland JM, et al: Possible pathogenetic factors in neonatal hypocalcemia of prematurity: The role of gestation, hyperphosphatemia, hypomagnesemia, urinary calcium loss, and parathormone responsiveness . J Pediatr 82:423-429, 1973.Crossref 10. Brown DR, Tsang RC, Chen IW: Oral calcium supplementation in premature and asphyxiated neonates . J Pediatr 89:973-977, 1976.Crossref 11. Pitkin RM, Gebhardt MP: Serum calcium concentrations in human pregnancy . Am J Obstet Gynecol 127:775-778, 1977. 12. Tan CM, Raman A: Serum ionic calcium levels during pregnancy . J Obstet Gynaecol Br Commonw 79:694-697, 1972.Crossref 13. Cushard WG, Creditor MA, Canterbury JM, et al: Physiologic hyperparathyroidism in pregnancy . J Clin Endocrinol Metab 34:767-771, 1972.Crossref 14. Ramberg CF, Delivoria-Papadopoulos M, Crandall ED, et al: Kinetic analysis of calcium transport across the placenta . J Appl Physiol 35:682-688, 1973. 15. Fleischman AR, Lerman S, Oakes G, et al: Perinatal primate parathyroid hormone metabolism . Biol Neonate 27:40-49, 1975.Crossref 16. Dirksen HC, Anast CS: Elevated circulating immunoreactive parathyroid hormone in premature infants , abstracted. Pediatr Res 11:425, 1977.Crossref 17. Ponchon G, DeLuca HF: The role of the liver in the metabolism of vitamin D . J Clin Invest 48:1273-1276, 1969.Crossref 18. Lawson D, Fraser DR, Kodicek E: Identification of 1,25-dihydroxycholecalciferol: A new kidney hormone controlling calcium metabolism . Nature 230:228-230, 1971.Crossref 19. Turton CWG, Stanley P, Stamp TCB, et al: Altered vitamin-D metabolism in pregnancy . Lancet 1:222-225, 1977.Crossref 20. Hillman LS, Haddad JG: Human perinatal vitamin D metabolism: I. 25-hydroxyvitamin D in maternal and cord blood . J Pediatr 84:742-749, 1974.Crossref 21. Hillman LS, Haddad JG: Perinatal vitamin D metabolism: II. Serial 25-hydroxyvitamin D concentrations in sera of term and premature infants . J Pediatr 86:928-935, 1975.Crossref 22. Rosen JF, Finberg L: Vitamin D-dependent rickets: Action of parathyroid hormone and 25-hydroxycholecalciferol . Pediatr Res 6:552-562, 1972.Crossref 23. Sorell M, Rosen JF: Ionized calcium: Serum levels during symptomatic hypocalcemia . J Pediatr 87:67-70, 1975.Crossref 24. Berger PE, Heidelberger KP, Poznanski AK: Extravasation of calcium gluconate as a cause of soft tissue calcification in infancy . Am J Roentgenol Radium Ther Nucl Med 121:109-117, 1974.Crossref 25. Ramamurthy RS, Harris V, Pildes RS: Subcutaneous calcium deposition in the neonate associated with intravenous administration of calcium gluconate . Pediatrics 55:802-806, 1975. 26. Weiss Y, Ackerman C, Shmilovitz L: Localized necrosis of scalp in neonates due to calcium gluconate infusions: A cautionary note . Pediatrics 56:1084-1086, 1975. 27. Pincus JB, Gittleman IF, Marius N, et al: The effect of graded doses of vitamin D or the serum calcium and phosphorus levels . Am J Dis Child 96:16-22, 1958.Crossref 28. Balsan S, Garabedian M, Sorgniard R, et al: 1,25-dihydroxyvitamin D3 and 1,α-hydroxyvitamin D3 in children: Biological and therapeutic effects in nutritional rickets and different types of vitamin D resistance . Pediatr Res 9:586-593, 1975.Crossref 29. Rosen JF, Fleischman AR, Finberg L, et al: 1,25-dihydroxycholecalciferol: Its use in the long-term management of idiopathic hypoparathyroidism in children . J Clin Endocrinol Metab 45:457-468, 1977.Crossref 30. Kooh SW, Fraser D, Toon R, et al: Response of protracted neonatal hypocalcemia to 1,α-25-dihydroxyvitamin D3 . Lancet 2:1105-1107, 1976.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png American Journal of Diseases of Children American Medical Association

25-Hydroxycholecalciferol for Early Neonatal Hypocalcemia: Occurrence in Premature Newborns

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References (37)

Publisher
American Medical Association
Copyright
Copyright © 1978 American Medical Association. All Rights Reserved.
ISSN
0002-922X
DOI
10.1001/archpedi.1978.02120350037005
Publisher site
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Abstract

Abstract • Oral 25-hydroxycholecalciferol (250HD3) has been used to prevent early neonatal hypocalcemia. Thirty premature neonates were studied prospectively from birth: 22 premature infants constituted a control group, and eight were treated orally with 250HD3 (2 μg/kg/day) for five days beginning within the first 12 hours of life. Eleven of the 22 premature infants in the control group became hypocalcemic, with serum ionized calcium (Ca++) level less than 3.0 mg/dl and total calcium (CaT) level less than 7.0 mg/dl on day 2 of life. Only one of the eight premature infants treated with 250HD3 became hypocalcemic. In treated neonates, serum 25-hydroxyvitamin D, as well as serum Ca and CaT levels, increased during the first five days of life and were considerably greater than levels in control neonates. No untoward effects of this treatment were observed. (Am J Dis Child 132:973-977, 1978) References 1. David L, Anast CS: Calcium metabolism in newborn infants . J Clin Invest 54:287-296, 1974.Crossref 2. Tsang RC, Chen IW, Friedman MA, et al: Neonatal parathyroid function: Role of gestational age and postnatal age . J Pediatr 83:728-737, 1973.Crossref 3. Linarelli LG, Bobik J, Bobik C: Newborn urinary cyclic AMP and developmental renal responsiveness to parathyroid hormone . Pediatrics 50:14-23, 1972. 4. Dirksen C, Anast CS: Hypercalcitoninemia and neonatal hypocalcemia , abstracted. Pediatr Res 11:424, 1977.Crossref 5. Hillman LS, Rojanasathit S, Slatopolsky E, et al: Serial measurements of serum calcium, magnesium, parathyroid hormone, calcitonin, and 25-hydroxy-vitamin D in premature and term infants during the first week of life . Pediatr Res 11:739-744, 1977.Crossref 6. Rosen JF, Roginsky M, Nathenson G, et al: 25-hydroxyvitamin D: Plasma levels in mothers and their premature infants with neonatal hypocalcemia . Am J Dis Child 127:220-223, 1974.Crossref 7. Fleischman AR, Rosen JF, Moses ME: Prevention of early neonatal hypocalcemia with 25-hydroxycholecalciferol , abstracted. Pediatr Res 11:513, 1977.Crossref 8. Chan GM, Tsang RC, Chen IW, et al: Biochemical response to 1,25(OH)2 vitamin D supplementation in premature infants: A prospective study , in Norman AW, Schaefer K, Coburn JW, et al (eds): Vitamin D Biochemical, Chemical and Clinical Aspects Related to Calcium Metabolism . New York, Walter de Gruyter, 1977, pp 569-571. 9. Tsang RC, Light IJ, Sutherland JM, et al: Possible pathogenetic factors in neonatal hypocalcemia of prematurity: The role of gestation, hyperphosphatemia, hypomagnesemia, urinary calcium loss, and parathormone responsiveness . J Pediatr 82:423-429, 1973.Crossref 10. Brown DR, Tsang RC, Chen IW: Oral calcium supplementation in premature and asphyxiated neonates . J Pediatr 89:973-977, 1976.Crossref 11. Pitkin RM, Gebhardt MP: Serum calcium concentrations in human pregnancy . Am J Obstet Gynecol 127:775-778, 1977. 12. Tan CM, Raman A: Serum ionic calcium levels during pregnancy . J Obstet Gynaecol Br Commonw 79:694-697, 1972.Crossref 13. Cushard WG, Creditor MA, Canterbury JM, et al: Physiologic hyperparathyroidism in pregnancy . J Clin Endocrinol Metab 34:767-771, 1972.Crossref 14. Ramberg CF, Delivoria-Papadopoulos M, Crandall ED, et al: Kinetic analysis of calcium transport across the placenta . J Appl Physiol 35:682-688, 1973. 15. Fleischman AR, Lerman S, Oakes G, et al: Perinatal primate parathyroid hormone metabolism . Biol Neonate 27:40-49, 1975.Crossref 16. Dirksen HC, Anast CS: Elevated circulating immunoreactive parathyroid hormone in premature infants , abstracted. Pediatr Res 11:425, 1977.Crossref 17. Ponchon G, DeLuca HF: The role of the liver in the metabolism of vitamin D . J Clin Invest 48:1273-1276, 1969.Crossref 18. Lawson D, Fraser DR, Kodicek E: Identification of 1,25-dihydroxycholecalciferol: A new kidney hormone controlling calcium metabolism . Nature 230:228-230, 1971.Crossref 19. Turton CWG, Stanley P, Stamp TCB, et al: Altered vitamin-D metabolism in pregnancy . Lancet 1:222-225, 1977.Crossref 20. Hillman LS, Haddad JG: Human perinatal vitamin D metabolism: I. 25-hydroxyvitamin D in maternal and cord blood . J Pediatr 84:742-749, 1974.Crossref 21. Hillman LS, Haddad JG: Perinatal vitamin D metabolism: II. Serial 25-hydroxyvitamin D concentrations in sera of term and premature infants . J Pediatr 86:928-935, 1975.Crossref 22. Rosen JF, Finberg L: Vitamin D-dependent rickets: Action of parathyroid hormone and 25-hydroxycholecalciferol . Pediatr Res 6:552-562, 1972.Crossref 23. Sorell M, Rosen JF: Ionized calcium: Serum levels during symptomatic hypocalcemia . J Pediatr 87:67-70, 1975.Crossref 24. Berger PE, Heidelberger KP, Poznanski AK: Extravasation of calcium gluconate as a cause of soft tissue calcification in infancy . Am J Roentgenol Radium Ther Nucl Med 121:109-117, 1974.Crossref 25. Ramamurthy RS, Harris V, Pildes RS: Subcutaneous calcium deposition in the neonate associated with intravenous administration of calcium gluconate . Pediatrics 55:802-806, 1975. 26. Weiss Y, Ackerman C, Shmilovitz L: Localized necrosis of scalp in neonates due to calcium gluconate infusions: A cautionary note . Pediatrics 56:1084-1086, 1975. 27. Pincus JB, Gittleman IF, Marius N, et al: The effect of graded doses of vitamin D or the serum calcium and phosphorus levels . Am J Dis Child 96:16-22, 1958.Crossref 28. Balsan S, Garabedian M, Sorgniard R, et al: 1,25-dihydroxyvitamin D3 and 1,α-hydroxyvitamin D3 in children: Biological and therapeutic effects in nutritional rickets and different types of vitamin D resistance . Pediatr Res 9:586-593, 1975.Crossref 29. Rosen JF, Fleischman AR, Finberg L, et al: 1,25-dihydroxycholecalciferol: Its use in the long-term management of idiopathic hypoparathyroidism in children . J Clin Endocrinol Metab 45:457-468, 1977.Crossref 30. Kooh SW, Fraser D, Toon R, et al: Response of protracted neonatal hypocalcemia to 1,α-25-dihydroxyvitamin D3 . Lancet 2:1105-1107, 1976.Crossref

Journal

American Journal of Diseases of Children – American Medical Association

Published: Oct 1, 1978

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