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Whole-Tumor Perfusion CT Parameters and Glucose Metabolism Measurements in Head and Neck Squamous Cell Carcinomas: A Pilot Study Using Combined Positron-Emission Tomography/CT Imaging

Whole-Tumor Perfusion CT Parameters and Glucose Metabolism Measurements in Head and Neck Squamous... This Article Figures Only Full Text Full Text (PDF) All Versions of this Article: ajnr.A1111v1 29/7/1376 most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Bisdas, S. Articles by Rumboldt, Z. Search for Related Content PubMed PubMed Citation Articles by Bisdas, S. Articles by Rumboldt, Z. Hotlight (NEW!) What's Hotlight? American Journal of Neuroradiology 29:1376-1381, August 2008 © 2008 American Society of Neuroradiology HEAD & NECK Whole-Tumor Perfusion CT Parameters and Glucose Metabolism Measurements in Head and Neck Squamous Cell Carcinomas: A Pilot Study Using Combined Positron-Emission Tomography/CT Imaging S. Bisdas a ,b , K. Spicer a and Z. Rumboldt a a Department of Radiology, Medical University of South Carolina, Charleston, SC b Department of Radiology, Johann Wolfgang Goethe University Hospital, Frankfurt, Germany Please address correspondence to Zoran Rumboldt, MD, Department of Radiology, Medical University of South Carolina, 169 Ashley Ave, Charleston, SC 29425; e-mail: rumbolz@musc.edu BACKGROUND AND PURPOSE: Previous (separately performed) perfusion CT (PCT) and PET studies have been inconclusive regarding the correlation of functional tumor characteristics. The purpose of this study was to perform dual assessment of head and neck squamous cell carcinomas (SCCAs) to examine the relationship between perfusion measurements derived from PCT and glucose standardized uptake values (SUV). MATERIALS AND METHODS: We prospectively evaluated 15 primary and recurrent SCCAs using combined positron-emission tomography (PET) and CT of the head and neck. SUV mean , SUV max , blood flow (BF), blood volume (BV), mean transit time (MTT), and permeability (PS) values were calculated with use of manually drawn regions of interest (ROIs) over the lesions and the healthy muscle tissue. Parametric comparison test, correlation coefficients, and regression analysis were performed. RESULTS: The mean (± SD) SUV mean , SUV max , BF, BV, MTT, and PS values in the tumor tissue were 6.26 (± 1.48), 15.25 (± 3.81), 91.50 (± 24.69), 5.08 (± 1.17), 7.51 (± 2.24), and 23.08 (± 8.77), respectively. All PET/CT and PCT parameters of muscle versus tumor tissue were statistically different (.0001 < P < .001). There were significant correlations between BF and SUV max as well as SUV mean ( r = 0.57; P = .02 and r = 0.63; P = .011, respectively) in the tumors. Significant correlation was also found between PS and SUV mean ( r = 0.53; P = .04) in the tumors. Regression analysis showed: SUV max = 0.09 x BF + 7.2 ( R 2 = 0.33; P = .02), SUV mean = 0.05 x BF + 2.22 ( R 2 = 0.45; P = .011), and SUV mean = 0.05 x PS + 5.36 ( R 2 = 0.35; P = .04). The tumor to nontumor (muscle) SUV mean and SUV max ratio was 9.45 (± 3.55) and 17.58 (± 4.32), respectively. BF-ratio SUV mean and BF-ratio SUV max showed significant correlations ( r = 0.64; P = .01 and r = 0.53; P = .04, respectively). Regression analysis showed ratio SUV mean = 0.14 x BF-3.48 ( R 2 = 0.42; P = .01) and ratio SUV max = 0.14 x BF + 4.51 ( R 2 = 0.29; P = .04). CONCLUSION: Tissue perfusion-metabolic coupling is evident in head and neck SCCAs and may provide additional diagnostic information in patients undergoing PET/CT studies. This article has been cited by other articles: L. Faggioni, E. Neri, and C. Bartolozzi CT Perfusion of Head and Neck Tumors: How We Do It Am. J. Roentgenol., January 1, 2010; 194(1): 62 - 69. Abstract Full Text PDF A.C. Miracle, A. Rezaei, D. Gandhi, and S.K. Mukherji CT Perfusion of the Neck: Internal Carotid Artery versus External Carotid Artery as the Reference Artery AJNR Am. J. Neuroradiol., September 1, 2009; 30(8): 1598 - 1601. Abstract Full Text PDF Home Subscribe Author Instructions Submit Online Search the AJNR Archives Feedback Help Copyright © 2010 by the American Society of Neuroradiology. Print ISSN: 0195-6108 Online ISSN: 1936-959X http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png American Journal of Neuroradiology American Journal of Neuroradiology

Whole-Tumor Perfusion CT Parameters and Glucose Metabolism Measurements in Head and Neck Squamous Cell Carcinomas: A Pilot Study Using Combined Positron-Emission Tomography/CT Imaging

American Journal of Neuroradiology , Volume 29 (7): 1376 – Aug 1, 2008

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Publisher
American Journal of Neuroradiology
Copyright
Copyright © 2010 by the American Society of Neuroradiology.
ISSN
0195-6108
eISSN
1936-959X
DOI
10.3174/ajnr.A1111
Publisher site
See Article on Publisher Site

Abstract

This Article Figures Only Full Text Full Text (PDF) All Versions of this Article: ajnr.A1111v1 29/7/1376 most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Bisdas, S. Articles by Rumboldt, Z. Search for Related Content PubMed PubMed Citation Articles by Bisdas, S. Articles by Rumboldt, Z. Hotlight (NEW!) What's Hotlight? American Journal of Neuroradiology 29:1376-1381, August 2008 © 2008 American Society of Neuroradiology HEAD & NECK Whole-Tumor Perfusion CT Parameters and Glucose Metabolism Measurements in Head and Neck Squamous Cell Carcinomas: A Pilot Study Using Combined Positron-Emission Tomography/CT Imaging S. Bisdas a ,b , K. Spicer a and Z. Rumboldt a a Department of Radiology, Medical University of South Carolina, Charleston, SC b Department of Radiology, Johann Wolfgang Goethe University Hospital, Frankfurt, Germany Please address correspondence to Zoran Rumboldt, MD, Department of Radiology, Medical University of South Carolina, 169 Ashley Ave, Charleston, SC 29425; e-mail: rumbolz@musc.edu BACKGROUND AND PURPOSE: Previous (separately performed) perfusion CT (PCT) and PET studies have been inconclusive regarding the correlation of functional tumor characteristics. The purpose of this study was to perform dual assessment of head and neck squamous cell carcinomas (SCCAs) to examine the relationship between perfusion measurements derived from PCT and glucose standardized uptake values (SUV). MATERIALS AND METHODS: We prospectively evaluated 15 primary and recurrent SCCAs using combined positron-emission tomography (PET) and CT of the head and neck. SUV mean , SUV max , blood flow (BF), blood volume (BV), mean transit time (MTT), and permeability (PS) values were calculated with use of manually drawn regions of interest (ROIs) over the lesions and the healthy muscle tissue. Parametric comparison test, correlation coefficients, and regression analysis were performed. RESULTS: The mean (± SD) SUV mean , SUV max , BF, BV, MTT, and PS values in the tumor tissue were 6.26 (± 1.48), 15.25 (± 3.81), 91.50 (± 24.69), 5.08 (± 1.17), 7.51 (± 2.24), and 23.08 (± 8.77), respectively. All PET/CT and PCT parameters of muscle versus tumor tissue were statistically different (.0001 < P < .001). There were significant correlations between BF and SUV max as well as SUV mean ( r = 0.57; P = .02 and r = 0.63; P = .011, respectively) in the tumors. Significant correlation was also found between PS and SUV mean ( r = 0.53; P = .04) in the tumors. Regression analysis showed: SUV max = 0.09 x BF + 7.2 ( R 2 = 0.33; P = .02), SUV mean = 0.05 x BF + 2.22 ( R 2 = 0.45; P = .011), and SUV mean = 0.05 x PS + 5.36 ( R 2 = 0.35; P = .04). The tumor to nontumor (muscle) SUV mean and SUV max ratio was 9.45 (± 3.55) and 17.58 (± 4.32), respectively. BF-ratio SUV mean and BF-ratio SUV max showed significant correlations ( r = 0.64; P = .01 and r = 0.53; P = .04, respectively). Regression analysis showed ratio SUV mean = 0.14 x BF-3.48 ( R 2 = 0.42; P = .01) and ratio SUV max = 0.14 x BF + 4.51 ( R 2 = 0.29; P = .04). CONCLUSION: Tissue perfusion-metabolic coupling is evident in head and neck SCCAs and may provide additional diagnostic information in patients undergoing PET/CT studies. This article has been cited by other articles: L. Faggioni, E. Neri, and C. Bartolozzi CT Perfusion of Head and Neck Tumors: How We Do It Am. J. Roentgenol., January 1, 2010; 194(1): 62 - 69. Abstract Full Text PDF A.C. Miracle, A. Rezaei, D. Gandhi, and S.K. Mukherji CT Perfusion of the Neck: Internal Carotid Artery versus External Carotid Artery as the Reference Artery AJNR Am. J. Neuroradiol., September 1, 2009; 30(8): 1598 - 1601. Abstract Full Text PDF Home Subscribe Author Instructions Submit Online Search the AJNR Archives Feedback Help Copyright © 2010 by the American Society of Neuroradiology. Print ISSN: 0195-6108 Online ISSN: 1936-959X

Journal

American Journal of NeuroradiologyAmerican Journal of Neuroradiology

Published: Aug 1, 2008

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