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Whole-Brain Perfusion CT Patterns of Brain Arteriovenous Malformations: A Pilot Study in 18 Patients

Whole-Brain Perfusion CT Patterns of Brain Arteriovenous Malformations: A Pilot Study in 18 Patients BACKGROUND AND PURPOSE: Little is known about the pathological mechanism or the anatomic and functional imaging features related to the clinical manifestations in patients with brain AVM. The purpose of this pilot study was to describe the pattern of whole-brain PCT abnormalities in brain AVMs and their potential to differentiate underlying pathomechanisms. MATERIALS AND METHODS: Whole-brain PCT performed on a 320−detector row CT scanner was analyzed in 18 patients with untreated brain AVMs. The patterns of perfusion abnormalities on CBV, CBF, and MTT maps were analyzed and were related to clinical presentation and cerebral angiography. RESULTS: The presenting symptoms were seizures ( n = 5), focal neurologic deficit ( n = 5), hemorrhage ( n = 4), chemosis ( n = 1), and none ( n = 3). Three types of extranidal brain parenchymal perfusion abnormalities were noted. Decreased CBF, CBV, and MTT (pattern 1, “functional” arterial steal) were identified in 8 patients. Seizure was the most common presenting symptom in these patients ( n = 5). Decreased CBF and CBV, and increased MTT (pattern 2, “ischemic” arterial steal) were noted in 4 patients. Focal neurologic deficit was the most common presenting symptom for these patients ( n = 3). Increased CBV and MTT (pattern 3, venous congestion) were seen in 5 patients with presenting symptoms of neurologic deficit ( n = 2), seizure ( n = 1), hemorrhage ( n = 1), and chemosis ( n = 1). In 2 patients, pre- and posttreatment PCT was performed, which showed improvement of perfusion abnormalities. CONCLUSIONS: Whole-brain PCT shows different patterns of perfusion abnormalities in patients with brain AVM. These perfusion patterns may discriminate the different pathologic mechanisms involved in these malformations. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png American Journal of Neuroradiology American Journal of Neuroradiology

Whole-Brain Perfusion CT Patterns of Brain Arteriovenous Malformations: A Pilot Study in 18 Patients

American Journal of Neuroradiology , Volume 32 (11): 2061 – Dec 1, 2011

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Publisher
American Journal of Neuroradiology
Copyright
Copyright © 2011 by the American Society of Neuroradiology.
ISSN
0195-6108
eISSN
1936-959X
DOI
10.3174/ajnr.A2659
pmid
21885720
Publisher site
See Article on Publisher Site

Abstract

BACKGROUND AND PURPOSE: Little is known about the pathological mechanism or the anatomic and functional imaging features related to the clinical manifestations in patients with brain AVM. The purpose of this pilot study was to describe the pattern of whole-brain PCT abnormalities in brain AVMs and their potential to differentiate underlying pathomechanisms. MATERIALS AND METHODS: Whole-brain PCT performed on a 320−detector row CT scanner was analyzed in 18 patients with untreated brain AVMs. The patterns of perfusion abnormalities on CBV, CBF, and MTT maps were analyzed and were related to clinical presentation and cerebral angiography. RESULTS: The presenting symptoms were seizures ( n = 5), focal neurologic deficit ( n = 5), hemorrhage ( n = 4), chemosis ( n = 1), and none ( n = 3). Three types of extranidal brain parenchymal perfusion abnormalities were noted. Decreased CBF, CBV, and MTT (pattern 1, “functional” arterial steal) were identified in 8 patients. Seizure was the most common presenting symptom in these patients ( n = 5). Decreased CBF and CBV, and increased MTT (pattern 2, “ischemic” arterial steal) were noted in 4 patients. Focal neurologic deficit was the most common presenting symptom for these patients ( n = 3). Increased CBV and MTT (pattern 3, venous congestion) were seen in 5 patients with presenting symptoms of neurologic deficit ( n = 2), seizure ( n = 1), hemorrhage ( n = 1), and chemosis ( n = 1). In 2 patients, pre- and posttreatment PCT was performed, which showed improvement of perfusion abnormalities. CONCLUSIONS: Whole-brain PCT shows different patterns of perfusion abnormalities in patients with brain AVM. These perfusion patterns may discriminate the different pathologic mechanisms involved in these malformations.

Journal

American Journal of NeuroradiologyAmerican Journal of Neuroradiology

Published: Dec 1, 2011

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