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White Matter Lesions Suggestive of Amyotrophic Lateral Sclerosis Attributed to Celiac Disease

White Matter Lesions Suggestive of Amyotrophic Lateral Sclerosis Attributed to Celiac Disease This Article Figures Only Full Text Full Text (PDF) All Versions of this Article: ajnr.A1826v1 31/5/880 most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via CrossRef Google Scholar Articles by Brown, K. J. Articles by Castillo, M. PubMed PubMed Citation Articles by Brown, K. J. Articles by Castillo, M. Hotlight (NEW!) What's Hotlight? American Journal of Neuroradiology 31:880-881, May 2010 © 2010 American Society of Neuroradiology Case Report BRAIN White Matter Lesions Suggestive of Amyotrophic Lateral Sclerosis Attributed to Celiac Disease K.J. Brown a , V. Jewells a , H. Herfarth b and M. Castillo a a From the Department of Radiology (K.J.B., V.J., M.C.) b Division of Gastroenterology and Hepatology (H.H.), University of North Carolina, Chapel Hill, North Carolina. Please address correspondence to Kelan J. Brown, MD, Department of Radiology, University of North Carolina, 2036 Old Clinic Bldg, CB 7510, Chapel Hill, NC, 27599-7510; e-mail: kelanbrown@gmail.com SUMMARY: CD is an autoimmune-mediated disorder of the gastrointestinal tract. Initial symptom presentation is variable and can include neurologic manifestations that may comprise ataxia, neuropathy, dizziness, epilepsy, and cortical calcifications rather than gastrointestinal-hindering diagnosis and management. We present a case of a young man with progressive neurologic symptoms and brain MR imaging findings worrisome for ALS. During the diagnostic work-up, endomysium antibodies were discovered, and CD was confirmed by upper gastrointestinal endoscopy with duodenal biopsies. MR imaging findings suggestive of ALS improved after gluten-free diet institution. Abbreviations: ALS, amyotrophic lateral sclerosis • CD, celiac disease • FLAIR, fluid-attenuated inversion recovery • IgA, immunoglobulin A Home Subscribe Author Instructions Submit Online Search the AJNR Archives Feedback Help Copyright © 2010 by the American Society of Neuroradiology. Print ISSN: 0195-6108 Online ISSN: 1936-959X http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png American Journal of Neuroradiology American Journal of Neuroradiology

White Matter Lesions Suggestive of Amyotrophic Lateral Sclerosis Attributed to Celiac Disease

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Publisher
American Journal of Neuroradiology
Copyright
Copyright © 2010 by the American Society of Neuroradiology.
ISSN
0195-6108
eISSN
1936-959X
DOI
10.3174/ajnr.A1826
Publisher site
See Article on Publisher Site

Abstract

This Article Figures Only Full Text Full Text (PDF) All Versions of this Article: ajnr.A1826v1 31/5/880 most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via CrossRef Google Scholar Articles by Brown, K. J. Articles by Castillo, M. PubMed PubMed Citation Articles by Brown, K. J. Articles by Castillo, M. Hotlight (NEW!) What's Hotlight? American Journal of Neuroradiology 31:880-881, May 2010 © 2010 American Society of Neuroradiology Case Report BRAIN White Matter Lesions Suggestive of Amyotrophic Lateral Sclerosis Attributed to Celiac Disease K.J. Brown a , V. Jewells a , H. Herfarth b and M. Castillo a a From the Department of Radiology (K.J.B., V.J., M.C.) b Division of Gastroenterology and Hepatology (H.H.), University of North Carolina, Chapel Hill, North Carolina. Please address correspondence to Kelan J. Brown, MD, Department of Radiology, University of North Carolina, 2036 Old Clinic Bldg, CB 7510, Chapel Hill, NC, 27599-7510; e-mail: kelanbrown@gmail.com SUMMARY: CD is an autoimmune-mediated disorder of the gastrointestinal tract. Initial symptom presentation is variable and can include neurologic manifestations that may comprise ataxia, neuropathy, dizziness, epilepsy, and cortical calcifications rather than gastrointestinal-hindering diagnosis and management. We present a case of a young man with progressive neurologic symptoms and brain MR imaging findings worrisome for ALS. During the diagnostic work-up, endomysium antibodies were discovered, and CD was confirmed by upper gastrointestinal endoscopy with duodenal biopsies. MR imaging findings suggestive of ALS improved after gluten-free diet institution. Abbreviations: ALS, amyotrophic lateral sclerosis • CD, celiac disease • FLAIR, fluid-attenuated inversion recovery • IgA, immunoglobulin A Home Subscribe Author Instructions Submit Online Search the AJNR Archives Feedback Help Copyright © 2010 by the American Society of Neuroradiology. Print ISSN: 0195-6108 Online ISSN: 1936-959X

Journal

American Journal of NeuroradiologyAmerican Journal of Neuroradiology

Published: May 1, 2010

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