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The Utility of Molecular Imaging for Investigating Patients with Visual Hallucinations

The Utility of Molecular Imaging for Investigating Patients with Visual Hallucinations LETTERS The Utility of Molecular Imaging for Investigating Patients with Visual Hallucinations e read with interest the recent article entitled “Distin- Wguishing Neuroimaging Features in Patients Presenting with Visual Hallucinations” by Winton-Brown et al. They de- scribed the features of dementia with Lewy bodies (DLB) on multiplanar T1-weighted MR imaging. In our practice, we find the diagnosis of DLB challenging with anatomic imaging alone. Molecular imaging can be helpful for differentiating DLB from other causes of visual hallucinations and demen- 2-4 tia. We present examples of the imaging findings of DLB by using nigrostriatal dopamine terminal imaging with dopa- mine-transporter single-photon emission CT (DaTscan) with the radioligand [ I]FP-CIT (GE Healthcare, Buckingham- shire, United Kingdom) and FDG-PET. These imaging tech- FIG 1. A, Normal DaTscan findings with normal background activity. niques may be considered in addition to anatomic imaging in Thearrowsshownormalradiotraceruptakewithinthecaudatenuclei cases in which a diagnosis of DLB is suspected but remains and putamen bilaterally. B, Abnormal DaTscan findings in a 68-year- oldwomanwithvisualhallucinationsandcognitiveimpairment.There unclear. is reduced uptake within the caudate nuclei and putamina (arrows) DaTscan is used for the early detection of Parkinson dis- bilaterally with increased background activity (asterisk). In the clinical ease, to differentiate essential tremor and http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png American Journal of Neuroradiology American Journal of Neuroradiology

The Utility of Molecular Imaging for Investigating Patients with Visual Hallucinations

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Publisher
American Journal of Neuroradiology
Copyright
© 2016 by American Journal of Neuroradiology
ISSN
0195-6108
eISSN
1936-959X
DOI
10.3174/ajnr.A4937
Publisher site
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Abstract

LETTERS The Utility of Molecular Imaging for Investigating Patients with Visual Hallucinations e read with interest the recent article entitled “Distin- Wguishing Neuroimaging Features in Patients Presenting with Visual Hallucinations” by Winton-Brown et al. They de- scribed the features of dementia with Lewy bodies (DLB) on multiplanar T1-weighted MR imaging. In our practice, we find the diagnosis of DLB challenging with anatomic imaging alone. Molecular imaging can be helpful for differentiating DLB from other causes of visual hallucinations and demen- 2-4 tia. We present examples of the imaging findings of DLB by using nigrostriatal dopamine terminal imaging with dopa- mine-transporter single-photon emission CT (DaTscan) with the radioligand [ I]FP-CIT (GE Healthcare, Buckingham- shire, United Kingdom) and FDG-PET. These imaging tech- FIG 1. A, Normal DaTscan findings with normal background activity. niques may be considered in addition to anatomic imaging in Thearrowsshownormalradiotraceruptakewithinthecaudatenuclei cases in which a diagnosis of DLB is suspected but remains and putamen bilaterally. B, Abnormal DaTscan findings in a 68-year- oldwomanwithvisualhallucinationsandcognitiveimpairment.There unclear. is reduced uptake within the caudate nuclei and putamina (arrows) DaTscan is used for the early detection of Parkinson dis- bilaterally with increased background activity (asterisk). In the clinical ease, to differentiate essential tremor and

Journal

American Journal of Neuroradiology – American Journal of Neuroradiology

Published: Nov 1, 2016

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