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The Risk of Stroke and TIA in Nonstenotic Carotid Plaques: A Systematic Review and Meta-Analysis

The Risk of Stroke and TIA in Nonstenotic Carotid Plaques: A Systematic Review and Meta-Analysis ORIGINAL RESEARCH EXTRACRANIAL VASCULAR The Risk of Stroke and TIA in Nonstenotic Carotid Plaques: A Systematic Review and Meta-Analysis N. Singh, M. Marko, J.M. Ospel, M. Goyal, and M. Almekhlafi ABSTRACT BACKGROUND: Severe carotid stenosis carries a high risk of stroke. However, the risk of stroke with nonstenotic carotid plaques (,50%) is increasingly recognized. PURPOSE: We aimed to summarize the risk of TIA or stroke in patients with nonstenotic carotid plaques. DATA SOURCES: We performed a comprehensive systematic review and meta-analysis in patients with acute ischemic stroke in whom carotid imaging was performed using MEDLINE and the Cochrane Database, including studies published up to December 2019. STUDY SELECTION: Included studies had .10 patients with ,50% carotid plaques on any imaging technique andreportedthe incidence or recurrence of ischemic stroke/TIA. High-risk plaque features and the risk of progression to stenosis .50% were extracted if reported. DATA SYNTHESIS: We identified 31 studies reporting on the risk of ipsilateral stroke/TIA in patients with nonstenotic carotid pla- ques. Twenty-five studies (n ¼ 13,428 participants) reported on first-ever stroke/TIA and 6 studies (n ¼ 122 participants) reported on the recurrence of stroke/TIA. DATA ANALYSIS: The incidence of first-ever ipsilateral stroke/TIA was 0.5/100 person-years. The risk http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png American Journal of Neuroradiology American Journal of Neuroradiology

The Risk of Stroke and TIA in Nonstenotic Carotid Plaques: A Systematic Review and Meta-Analysis

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Publisher
American Journal of Neuroradiology
Copyright
© 2020 by American Journal of Neuroradiology
ISSN
0195-6108
eISSN
1936-959X
DOI
10.3174/ajnr.A6613
Publisher site
See Article on Publisher Site

Abstract

ORIGINAL RESEARCH EXTRACRANIAL VASCULAR The Risk of Stroke and TIA in Nonstenotic Carotid Plaques: A Systematic Review and Meta-Analysis N. Singh, M. Marko, J.M. Ospel, M. Goyal, and M. Almekhlafi ABSTRACT BACKGROUND: Severe carotid stenosis carries a high risk of stroke. However, the risk of stroke with nonstenotic carotid plaques (,50%) is increasingly recognized. PURPOSE: We aimed to summarize the risk of TIA or stroke in patients with nonstenotic carotid plaques. DATA SOURCES: We performed a comprehensive systematic review and meta-analysis in patients with acute ischemic stroke in whom carotid imaging was performed using MEDLINE and the Cochrane Database, including studies published up to December 2019. STUDY SELECTION: Included studies had .10 patients with ,50% carotid plaques on any imaging technique andreportedthe incidence or recurrence of ischemic stroke/TIA. High-risk plaque features and the risk of progression to stenosis .50% were extracted if reported. DATA SYNTHESIS: We identified 31 studies reporting on the risk of ipsilateral stroke/TIA in patients with nonstenotic carotid pla- ques. Twenty-five studies (n ¼ 13,428 participants) reported on first-ever stroke/TIA and 6 studies (n ¼ 122 participants) reported on the recurrence of stroke/TIA. DATA ANALYSIS: The incidence of first-ever ipsilateral stroke/TIA was 0.5/100 person-years. The risk

Journal

American Journal of NeuroradiologyAmerican Journal of Neuroradiology

Published: Aug 1, 2020

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