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The Globe and Orbit in Laron Syndrome

The Globe and Orbit in Laron Syndrome This Article Figures Only Full Text Full Text (PDF) All Versions of this Article: ajnr.A2573v1 32/8/1560 most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via CrossRef Google Scholar Articles by Kornreich, L. Articles by Laron, Z. PubMed PubMed Citation Articles by Kornreich, L. Articles by Laron, Z. Hotlight (NEW!) What's Hotlight? American Journal of Neuroradiology 32:1560-1562, September 2011 © 2011 American Society of Neuroradiology HEAD AND NECK The Globe and Orbit in Laron Syndrome L. Kornreich a ,c , O. Konen a ,c , P. Lilos b ,c and Z. Laron b ,c a From the Imaging Department (L.K., O.K.) b Endocrinology and Diabetes Research Unit (P.L., Z.L.), Schneider Children's Medical Center of Israel, Petah Tiqwa, Israel c Sackler Faculty of Medicine (L.K., O.K., P.L., Z.L.), Tel Aviv University, Tel Aviv, Israel. Please address correspondence to L. Kornreich, MD, Imaging Department, Schneider Children's Medical Center of Israel, Petah Tiqwa 49202, Israel; e-mail: korn@netvision.net.il BACKGROUND AND PURPOSE: Patients with LS have an inborn growth hormone resistance, resulting in failure to generate IGF-1. The purpose of this study was to evaluate the size of the eye and orbit in LS. MATERIALS AND METHODS: We retrospectively reviewed the MR imaging of the brain in 9 patients with LS for the following parameters: axial diameter of the globe, interzygomatic distance, perpendicular distance from the interzygomatic line to margins of the globe, medial-to-lateral diameter of the orbit at the anterior orbital rim, distance from the anterior orbital rim to the anterior globe, maximal distance between the medial walls of the orbits, lateral orbital wall angle, lateral orbital wall length, and mediolateral thickness of the intraorbital fat in the most cranial image of the orbit. All measurements were made bilaterally. Twenty patients referred for MR imaging for unrelated reasons served as control subjects. RESULTS: Compared with the control group, the patients with LS had a significantly smaller maximal globe diameter and shallower but wider orbits due to a shorter lateral wall, a smaller medial distance between the orbits, and a larger angle of the orbit. The ratio between the most anterior orbital diameter and the globe was greater than that in controls. The position of the globe was more anterior in relation to the interzygomatic line. CONCLUSIONS: Shallow and wide orbits and small globes relative to orbital size are seen in LS and may be secondary to IGF-1 deficiency. Abbreviations: GH, growth hormone • IGF-1, insulin-like growth factor 1 • LS, Laron syndrome • NS, not significant Home Subscribe Author Instructions Submit Online Search the AJNR Archives Feedback Help Copyright © 2011 by the American Society of Neuroradiology. Print ISSN: 0195-6108 Online ISSN: 1936-959X http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png American Journal of Neuroradiology American Journal of Neuroradiology

The Globe and Orbit in Laron Syndrome

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Publisher
American Journal of Neuroradiology
Copyright
Copyright © 2011 by the American Society of Neuroradiology.
ISSN
0195-6108
eISSN
1936-959X
DOI
10.3174/ajnr.A2573
Publisher site
See Article on Publisher Site

Abstract

This Article Figures Only Full Text Full Text (PDF) All Versions of this Article: ajnr.A2573v1 32/8/1560 most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via CrossRef Google Scholar Articles by Kornreich, L. Articles by Laron, Z. PubMed PubMed Citation Articles by Kornreich, L. Articles by Laron, Z. Hotlight (NEW!) What's Hotlight? American Journal of Neuroradiology 32:1560-1562, September 2011 © 2011 American Society of Neuroradiology HEAD AND NECK The Globe and Orbit in Laron Syndrome L. Kornreich a ,c , O. Konen a ,c , P. Lilos b ,c and Z. Laron b ,c a From the Imaging Department (L.K., O.K.) b Endocrinology and Diabetes Research Unit (P.L., Z.L.), Schneider Children's Medical Center of Israel, Petah Tiqwa, Israel c Sackler Faculty of Medicine (L.K., O.K., P.L., Z.L.), Tel Aviv University, Tel Aviv, Israel. Please address correspondence to L. Kornreich, MD, Imaging Department, Schneider Children's Medical Center of Israel, Petah Tiqwa 49202, Israel; e-mail: korn@netvision.net.il BACKGROUND AND PURPOSE: Patients with LS have an inborn growth hormone resistance, resulting in failure to generate IGF-1. The purpose of this study was to evaluate the size of the eye and orbit in LS. MATERIALS AND METHODS: We retrospectively reviewed the MR imaging of the brain in 9 patients with LS for the following parameters: axial diameter of the globe, interzygomatic distance, perpendicular distance from the interzygomatic line to margins of the globe, medial-to-lateral diameter of the orbit at the anterior orbital rim, distance from the anterior orbital rim to the anterior globe, maximal distance between the medial walls of the orbits, lateral orbital wall angle, lateral orbital wall length, and mediolateral thickness of the intraorbital fat in the most cranial image of the orbit. All measurements were made bilaterally. Twenty patients referred for MR imaging for unrelated reasons served as control subjects. RESULTS: Compared with the control group, the patients with LS had a significantly smaller maximal globe diameter and shallower but wider orbits due to a shorter lateral wall, a smaller medial distance between the orbits, and a larger angle of the orbit. The ratio between the most anterior orbital diameter and the globe was greater than that in controls. The position of the globe was more anterior in relation to the interzygomatic line. CONCLUSIONS: Shallow and wide orbits and small globes relative to orbital size are seen in LS and may be secondary to IGF-1 deficiency. Abbreviations: GH, growth hormone • IGF-1, insulin-like growth factor 1 • LS, Laron syndrome • NS, not significant Home Subscribe Author Instructions Submit Online Search the AJNR Archives Feedback Help Copyright © 2011 by the American Society of Neuroradiology. Print ISSN: 0195-6108 Online ISSN: 1936-959X

Journal

American Journal of Neuroradiology – American Journal of Neuroradiology

Published: Sep 1, 2011

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