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The Effect of Exercise on the Cerebral Vasculature of Healthy Aged Subjects as Visualized by MR Angiography

The Effect of Exercise on the Cerebral Vasculature of Healthy Aged Subjects as Visualized by MR... This Article Free to Access Figures Only Full Text Full Text (PDF) All Versions of this Article: ajnr.A1695v1 ajnr.A1695v2 30/10/1857 most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Bullitt, E. Articles by Marks, B.L. Search for Related Content PubMed PubMed Citation Articles by Bullitt, E. Articles by Marks, B.L. Hotlight (NEW!) What's Hotlight? American Journal of Neuroradiology 30:1857-1863, November-December 2009 © 2009 American Society of Neuroradiology BRAIN The Effect of Exercise on the Cerebral Vasculature of Healthy Aged Subjects as Visualized by MR Angiography E. Bullitt a , F.N. Rahman b , J.K. Smith b , E. Kim c , D. Zeng c , L.M. Katz d and B.L. Marks e a From the Departments of Surgery (E.B.) b Radiology (F.N.R., J.K.S.) c Biostatistics (E.K., D.Z.) d Emergency Medicine (L.M.K.) e Sports Medicine (B.L.M.), University of North Carolina at Chapel Hill, Chapel Hill, NC. Please address correspondence to Elizabeth Bullitt, MD, Department of Surgery, CASILab, CB#7062, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599; e-mail: bullitt@med.unc.edu BACKGROUND AND PURPOSE: Prior studies suggest that aerobic exercise may reduce both the brain atrophy and the decline in fractional anisotropy observed with advancing age. It is reasonable to hypothesize that exercise-induced changes to the vasculature may underlie these anatomic differences. The purpose of this blinded study was to compare high-activity and low-activity healthy elderly volunteers for differences in the cerebrovasculature as calculated from vessels extracted from noninvasive MR angiograms (MRAs). MATERIALS AND METHODS: Fourteen healthy elderly subjects underwent MRA. Seven subjects reported a high level of aerobic activity (64 ± 5 years of age; 5 men, 2 women) and 7, a low activity level (68 ± 6 years of age; 5 women, 2 men). Following vessel segmentation from MRA by an individual blinded to subject activity level, quantitative measures of vessel number, radius, and tortuosity were calculated and histogram analysis of vessel number and radius was performed. RESULTS: Aerobically active subjects exhibited statistically significant reductions in vessel tortuosity and an increased number of small vessels compared with less active subjects. CONCLUSIONS: Aerobic activity in elderly subjects is associated with lower vessel tortuosity values and an increase in the number of small-caliber vessels. It is possible that an aerobic exercise program may contribute to healthy brain aging. MRA offers a noninvasive approach to visualizing the cerebral vasculature and may prove useful in future longitudinal investigations. Home Subscribe Author Instructions Submit Online Search the AJNR Archives Feedback Help Copyright © 2010 by the American Society of Neuroradiology. Print ISSN: 0195-6108 Online ISSN: 1936-959X http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png American Journal of Neuroradiology American Journal of Neuroradiology

The Effect of Exercise on the Cerebral Vasculature of Healthy Aged Subjects as Visualized by MR Angiography

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Publisher
American Journal of Neuroradiology
Copyright
Copyright © 2010 by the American Society of Neuroradiology.
ISSN
0195-6108
eISSN
1936-959X
DOI
10.3174/ajnr.A1695
Publisher site
See Article on Publisher Site

Abstract

This Article Free to Access Figures Only Full Text Full Text (PDF) All Versions of this Article: ajnr.A1695v1 ajnr.A1695v2 30/10/1857 most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Bullitt, E. Articles by Marks, B.L. Search for Related Content PubMed PubMed Citation Articles by Bullitt, E. Articles by Marks, B.L. Hotlight (NEW!) What's Hotlight? American Journal of Neuroradiology 30:1857-1863, November-December 2009 © 2009 American Society of Neuroradiology BRAIN The Effect of Exercise on the Cerebral Vasculature of Healthy Aged Subjects as Visualized by MR Angiography E. Bullitt a , F.N. Rahman b , J.K. Smith b , E. Kim c , D. Zeng c , L.M. Katz d and B.L. Marks e a From the Departments of Surgery (E.B.) b Radiology (F.N.R., J.K.S.) c Biostatistics (E.K., D.Z.) d Emergency Medicine (L.M.K.) e Sports Medicine (B.L.M.), University of North Carolina at Chapel Hill, Chapel Hill, NC. Please address correspondence to Elizabeth Bullitt, MD, Department of Surgery, CASILab, CB#7062, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599; e-mail: bullitt@med.unc.edu BACKGROUND AND PURPOSE: Prior studies suggest that aerobic exercise may reduce both the brain atrophy and the decline in fractional anisotropy observed with advancing age. It is reasonable to hypothesize that exercise-induced changes to the vasculature may underlie these anatomic differences. The purpose of this blinded study was to compare high-activity and low-activity healthy elderly volunteers for differences in the cerebrovasculature as calculated from vessels extracted from noninvasive MR angiograms (MRAs). MATERIALS AND METHODS: Fourteen healthy elderly subjects underwent MRA. Seven subjects reported a high level of aerobic activity (64 ± 5 years of age; 5 men, 2 women) and 7, a low activity level (68 ± 6 years of age; 5 women, 2 men). Following vessel segmentation from MRA by an individual blinded to subject activity level, quantitative measures of vessel number, radius, and tortuosity were calculated and histogram analysis of vessel number and radius was performed. RESULTS: Aerobically active subjects exhibited statistically significant reductions in vessel tortuosity and an increased number of small vessels compared with less active subjects. CONCLUSIONS: Aerobic activity in elderly subjects is associated with lower vessel tortuosity values and an increase in the number of small-caliber vessels. It is possible that an aerobic exercise program may contribute to healthy brain aging. MRA offers a noninvasive approach to visualizing the cerebral vasculature and may prove useful in future longitudinal investigations. Home Subscribe Author Instructions Submit Online Search the AJNR Archives Feedback Help Copyright © 2010 by the American Society of Neuroradiology. Print ISSN: 0195-6108 Online ISSN: 1936-959X

Journal

American Journal of NeuroradiologyAmerican Journal of Neuroradiology

Published: Nov 1, 2009

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