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ORIGINALRESEARCH ADULT BRAIN X S. Suthiphosuwan, X P. Sati, X M. Guenette, X X. Montalban, X D.S. Reich, X A. Bharatha, and X J. Oh ABSTRACT BACKGROUND AND PURPOSE: Radiologically isolated syndrome describes asymptomatic individuals with incidental radiologic abnor- malities suggestive of multiple sclerosis. Recent studies have demonstrated that 40% of white matter lesions in MS (and often substan- tially more) have visible central veins on MR imaging. This “central vein sign” reflects perivenous inflammatory demyelination and can assist in differentiating MS from other white matter disorders. We therefore hypothesized that 40% of white matter lesions in cases of radiologically isolated syndrome would show the central vein sign. MATERIALS AND METHODS: We recruited 20 participants diagnosed with radiologically isolated syndrome after evaluation by a neu- rologist. We performed 3T MR imaging of the brain and cervical spinal cord. White matter lesions were analyzed for the central vein sign. RESULTS: Of 391 total white matter lesions, 292 (75%) demonstrated the central vein sign (central vein sign). The median proportion of central vein sign lesions per case was 87% (range, 29%–100%). When the “40% rule” that has been proposed to distinguish MS from other disorders was applied, of 20 participants, 18
American Journal of Neuroradiology – American Journal of Neuroradiology
Published: May 1, 2019
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