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This Article Figures Only Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Bartlett, P.A. Articles by Duncan, J.S. Search for Related Content PubMed Articles by Bartlett, P.A. Articles by Duncan, J.S. Hotlight (NEW!) What's Hotlight? American Journal of Neuroradiology 28:1095-1098, June-July 2007 DOI 10.3174/ajnr.A0505 © 2007 American Society of Neuroradiology BRAIN T2 Relaxometry of the Hippocampus at 3T P.A. Bartlett a , M.R. Symms a , S.L. Free a and J.S. Duncan a a From the National Society for Epilepsy, MRI Unit, Department of Clinical and Experimental Epilepsy, Institute of Neurology UCL, Queen Square, London, UK Address correspondence to Philippa A. Bartlett, NSE MRI Unit, National Society for Epilepsy, Chalfont St Peter, London SL9 0LR, United Kingdom; e-mail: p.bartlett@ion.ucl.ac.uk BACKGROUND AND PURPOSE: T2 mapping is useful for identifying and quantifying abnormalities of the hippocampus and amygdala. It is particularly useful in the presurgical evaluation of patients with temporal lobe epilepsy and for the identification of bilateral hippocampal sclerosis (HS). The purpose of this study was to implement and validate a dual-echo method for producing coronal T2 maps with complete coverage of the hippocampus and the rest of the brain on a 3T MR imaging scanner. MATERIALS AND METHODS: T2 relaxation times were estimated on 10 occasions on 3 quality assessment Eurospin II (Diagnostic Sonar, Livingstone, Scotland) test objects with the use of conventional spin-echo (CSE), fast spin-echo, and fast recovery fast spin-echo (FRFSE) sequences on a 3T Excite MR imaging scanner (GE Healthcare, Milwaukee, Wis). Hippocampal T2 relaxation times were then measured in 15 healthy subjects and 20 subjects with clear-cut HS who were scanned at 1.5T with a previously validated dual-echo CSE sequence and 3T with an FRFSE sequence. RESULTS: 3T FRFSE data were as reliable as CSE data at 1.5T. Reliability of hippocampal T2 measures was good on healthy volunteers and subjects with HS. FRFSE images were suitable for qualitative radiologic reporting and with complete brain coverage, so no additional T2-weighted sequences were required. There was good correlation between the 3T hippocampal T2 measurements and values obtained with the previously validated technique at 1.5T, with reliable identification of all of the subjects with HS. CONCLUSIONS: T2 mapping with an FRFSE 30/80 sequence may be readily applied at 3T and can produce reliable T2 values in vivo with contiguous 5-mm sections and in a much reduced scan time of 3 minutes 1 second compared with 10 minutes 30 seconds for the CSE sequence at 1.5T. This article has been cited by other articles: S. B. Bonelli, R. H. W. Powell, M. Yogarajah, R. S. Samson, M. R. Symms, P. J. Thompson, M. J. Koepp, and J. S. Duncan Imaging memory in temporal lobe epilepsy: predicting the effects of temporal lobe resection Brain, April 1, 2010; 133(4): 1186 - 1199. Abstract Full Text PDF Home Subscribe Author Instructions Submit Online Search the AJNR Archives Feedback Help Copyright © 2010 by the American Society of Neuroradiology. Print ISSN: 0195-6108 Online ISSN: 1936-959X
American Journal of Neuroradiology – American Journal of Neuroradiology
Published: Jun 1, 2007
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