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ORIGINAL RESEARCH ADULT BRAIN Spatial Resolution and the Magnitude of Infarct Volume Measurement Error in DWI in Acute Ischemic Stroke J.M. Ospel, A. Jaffray, V. Schulze-Zachau, S. Kozerke, and C. Federau ABSTRACT BACKGROUND AND PURPOSE: Infarct volume in acute ischemic stroke is an important prognostic marker and determines endovas- cular treatment decisions. This study evaluates the magnitude and potential clinical impact of the error related to partial volume effects in infarct volume measurement on diffusion-weighted MR imaging in acute stroke and explores how increasing spatial reso- lution could reduce this error. MATERIALS AND METHODS: Diffusion-weighted imaging of 393 patients with acute stroke, of whom 56 had anterior circulation large-vessel occlusion, was coregistered to standard space. Lesion boundaries were manually segmented. A 3D lesion-volume model was resampled for voxel sizes from 4 4 8to 1 1 2 mm, and the surface-volume, corresponding to the partial volume error, was calculated. The number of cases with anterior circulation large-vessel occlusion, in which the endovascular therapy core threshold of 70 mL was contained within the margin of error, was calculated as a function of imaging resolution. RESULTS: The mean infarct core volume was 27.2 6 49.9 mL. The mean
American Journal of Neuroradiology – American Journal of Neuroradiology
Published: May 1, 2020
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