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Resting-State Functional MRI for Determining Language Lateralization in Children with Drug-Resistant Epilepsy

Resting-State Functional MRI for Determining Language Lateralization in Children with... ORIGINAL RESEARCH FUNCTIONAL Resting-State Functional MRI for Determining Language Lateralization in Children with Drug-Resistant Epilepsy N.L. Phillips, A.S. Shatil, C. Go, A. Robertson, and E. Widjaja ABSTRACT BACKGROUND AND PURPOSE: Task-based fMRI is a noninvasive method of determining language dominance; however, not all chil- dren can complete language tasks due to age, cognitive/intellectual, or language barriers. Task-free approaches such as resting-state fMRI offer an alternative method. This study evaluated resting-state fMRI for predicting language laterality in children with drug-re- sistant epilepsy. MATERIALS AND METHODS: A retrospective review of 43 children with drug-resistant epilepsy who had undergone resting-state fMRI and task-based fMRI during presurgical evaluation was conducted. Independent component analysis of resting-state fMRI was used to identify language networks by comparing the independent components with a language network template. Concordance rates in language laterality between resting-state fMRI and each of the 4 task-based fMRI language paradigms (auditory description decision, auditory category, verbal fluency, and silent word generation tasks) were calculated. RESULTS: Concordance ranged from 0.64 (95% CI, 0.48–0.65) to 0.73 (95% CI, 0.58–0.87), depending on the language paradigm, with the highest concordance found for the auditory description decision task. Most (78%–83%) patients identified as left-lateralized on task-based fMRI were correctly http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png American Journal of Neuroradiology American Journal of Neuroradiology

Resting-State Functional MRI for Determining Language Lateralization in Children with Drug-Resistant Epilepsy

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Publisher
American Journal of Neuroradiology
Copyright
© 2021 by American Journal of Neuroradiology
ISSN
0195-6108
eISSN
1936-959X
DOI
10.3174/ajnr.A7110
Publisher site
See Article on Publisher Site

Abstract

ORIGINAL RESEARCH FUNCTIONAL Resting-State Functional MRI for Determining Language Lateralization in Children with Drug-Resistant Epilepsy N.L. Phillips, A.S. Shatil, C. Go, A. Robertson, and E. Widjaja ABSTRACT BACKGROUND AND PURPOSE: Task-based fMRI is a noninvasive method of determining language dominance; however, not all chil- dren can complete language tasks due to age, cognitive/intellectual, or language barriers. Task-free approaches such as resting-state fMRI offer an alternative method. This study evaluated resting-state fMRI for predicting language laterality in children with drug-re- sistant epilepsy. MATERIALS AND METHODS: A retrospective review of 43 children with drug-resistant epilepsy who had undergone resting-state fMRI and task-based fMRI during presurgical evaluation was conducted. Independent component analysis of resting-state fMRI was used to identify language networks by comparing the independent components with a language network template. Concordance rates in language laterality between resting-state fMRI and each of the 4 task-based fMRI language paradigms (auditory description decision, auditory category, verbal fluency, and silent word generation tasks) were calculated. RESULTS: Concordance ranged from 0.64 (95% CI, 0.48–0.65) to 0.73 (95% CI, 0.58–0.87), depending on the language paradigm, with the highest concordance found for the auditory description decision task. Most (78%–83%) patients identified as left-lateralized on task-based fMRI were correctly

Journal

American Journal of NeuroradiologyAmerican Journal of Neuroradiology

Published: Jul 1, 2021

References