ORIGINAL RESEARCH ADULT BRAIN Regional Aneurysm Wall Enhancement is Affected by Local Hemodynamics: A 7T MRI Study S. Hadad, F. Mut, B.J. Chung, J.A. Roa, A.M. Robertson, D.M. Hasan, E.A. Samaniego, and J.R. Cebral ABSTRACT BACKGROUND AND PURPOSE: Aneurysm wall enhancement has been proposed as a biomarker for inﬂammation and instability. However, the mechanisms of aneurysm wall enhancement remain unclear. We used 7T MR imaging to determine the effect of ﬂow in different regions of the wall. MATERIALS AND METHODS: Twenty-three intracranial aneurysms imaged with 7T MR imaging and 3D angiography were studied with computational ﬂuid dynamics. Local ﬂow conditions were compared between aneurysm wall enhancement and nonenhanced regions. Aneurysm wall enhancement regions were subdivided according to their location on the aneurysm and relative to the inﬂow and were further compared. RESULTS: On average, wall shear stress was lower in enhanced than in nonenhanced regions (P¼ .05). Aneurysm wall enhancement regions at the neck had higher wall shear stress gradients (P¼ .05) with lower oscillations (P¼ .05) than nonenhanced regions. In contrast, aneurysm wall enhancement regions at the aneurysm body had lower wall shear stress (P¼ .01) and wall shear stress gra- dients (P¼ .008) than nonenhanced regions. Aneurysm
American Journal of Neuroradiology – American Journal of Neuroradiology
Published: Mar 1, 2021
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