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Quantitative and Qualitative Comparison of 4D-DSA with 3D-DSA Using Computational Fluid Dynamics Simulations in Cerebral Aneurysms

Quantitative and Qualitative Comparison of 4D-DSA with 3D-DSA Using Computational Fluid Dynamics... ORIGINALRESEARCH INTERVENTIONAL Quantitative and Qualitative Comparison of 4D-DSA with 3D-DSA Using Computational Fluid Dynamics Simulations in Cerebral Aneurysms X S. Lang, X P. Hoelter, X A.I. Birkhold, X M. Schmidt, X J. Endres, X C. Strother, X A. Doerfler, and X H. Luecking ABSTRACT BACKGROUND AND PURPOSE: 4D-DSA allows time-resolved 3D imaging of the cerebral vasculature. The aim of our study was to evaluatethismethodincomparisonwiththecurrentcriterionstandard3D-DSAbyqualitativeandquantitativemeansusingcomputational fluid dynamics. MATERIALSANDMETHODS: 3D-and4D-DSAdatasetswereacquiredinpatientswithcerebralaneurysms.Computationalfluiddynamics analysis was performed for all datasets. Using computational fluid dynamics, we compared 4D-DSA with 3D-DSA in terms of both aneurysmal geometry (quantitative: maximum diameter, ostium size [OZ1/2], volume) and hemodynamic parameters (qualitative: flow stability, flow complexity, inflow concentration; quantitative: average/maximum wall shear stress, impingement zone, low-stress zone, intra-aneurysmalpressure,andflowvelocity).Qualitativeparametersweredescriptivelyanalyzed.Correlationcoefficients(r,Pvalue)were calculated for quantitative parameters. RESULTS: 3D- and 4D-DSA datasets of 10 cerebral aneurysms in 10 patients were postprocessed. Evaluation of aneurysmal geometry with 4D-DSA (r  0.98, P .001; r  0.98/0.86, P  .001/.002; r  0.98, P .001) maximum diameter maximum diameter OZ1/OZ2 OZ1/OZ2 volume volume correlated highly with 3D-DSA. Evaluation of qualitative hemodynamic parameters (flow stability, flow complexity, inflow concentration) didshowcompleteaccordance,andevaluationofquantitativehemodynamicparameters(r 0.92/0.88, average/maximum wall shear stress diastole P  .001/.001; r  0.94/0.93, P average/maximum wall shear stress diastole average/maximum http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png American Journal of Neuroradiology American Journal of Neuroradiology

Quantitative and Qualitative Comparison of 4D-DSA with 3D-DSA Using Computational Fluid Dynamics Simulations in Cerebral Aneurysms

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Publisher
American Journal of Neuroradiology
Copyright
© 2019 by American Journal of Neuroradiology
ISSN
0195-6108
eISSN
1936-959X
DOI
10.3174/ajnr.A6172
Publisher site
See Article on Publisher Site

Abstract

ORIGINALRESEARCH INTERVENTIONAL Quantitative and Qualitative Comparison of 4D-DSA with 3D-DSA Using Computational Fluid Dynamics Simulations in Cerebral Aneurysms X S. Lang, X P. Hoelter, X A.I. Birkhold, X M. Schmidt, X J. Endres, X C. Strother, X A. Doerfler, and X H. Luecking ABSTRACT BACKGROUND AND PURPOSE: 4D-DSA allows time-resolved 3D imaging of the cerebral vasculature. The aim of our study was to evaluatethismethodincomparisonwiththecurrentcriterionstandard3D-DSAbyqualitativeandquantitativemeansusingcomputational fluid dynamics. MATERIALSANDMETHODS: 3D-and4D-DSAdatasetswereacquiredinpatientswithcerebralaneurysms.Computationalfluiddynamics analysis was performed for all datasets. Using computational fluid dynamics, we compared 4D-DSA with 3D-DSA in terms of both aneurysmal geometry (quantitative: maximum diameter, ostium size [OZ1/2], volume) and hemodynamic parameters (qualitative: flow stability, flow complexity, inflow concentration; quantitative: average/maximum wall shear stress, impingement zone, low-stress zone, intra-aneurysmalpressure,andflowvelocity).Qualitativeparametersweredescriptivelyanalyzed.Correlationcoefficients(r,Pvalue)were calculated for quantitative parameters. RESULTS: 3D- and 4D-DSA datasets of 10 cerebral aneurysms in 10 patients were postprocessed. Evaluation of aneurysmal geometry with 4D-DSA (r  0.98, P .001; r  0.98/0.86, P  .001/.002; r  0.98, P .001) maximum diameter maximum diameter OZ1/OZ2 OZ1/OZ2 volume volume correlated highly with 3D-DSA. Evaluation of qualitative hemodynamic parameters (flow stability, flow complexity, inflow concentration) didshowcompleteaccordance,andevaluationofquantitativehemodynamicparameters(r 0.92/0.88, average/maximum wall shear stress diastole P  .001/.001; r  0.94/0.93, P average/maximum wall shear stress diastole average/maximum

Journal

American Journal of NeuroradiologyAmerican Journal of Neuroradiology

Published: Sep 1, 2019

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