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ORIGINAL RESEARCH INTERVENTIONAL Quantification of Blood Velocity with 4D Digital Subtraction Angiography Using the Shifted Least-Squares Method X Y. Wu, X G. Shaughnessy, X C.A. Hoffman, X E.L. Oberstar, X S. Schafer, X T. Schubert, X K.L. Ruedinger, X B.J. Davis, X C.A. Mistretta, X C.M. Strother, and X M.A. Speidel ABSTRACT BACKGROUND AND PURPOSE: 4D-DSA provides time-resolved 3D-DSA volumes with high temporal and spatial resolutions. The pur- pose of this study is to investigate a shifted least squares method to estimate the blood velocity from the 4D DSA images. Quantitative validation was performed using a flow phantom with an ultrasonic flow probe as ground truth. Quantification of blood velocity in human internal carotid arteries was compared with measurements generated from 3D phase-contrast MR imaging. MATERIALS AND METHODS: The centerlines of selected vascular segments and the time concentration curves of each voxel along the centerlines were determined from the 4D-DSA dataset. The temporal shift required to achieve a minimum difference between any point and other points along the centerline of a segment was calculated. The temporal shift as a function of centerline point position was fit to a straight line to generate the velocity. The proposed shifted least-squares method
American Journal of Neuroradiology – American Journal of Neuroradiology
Published: Oct 1, 2018
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