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Plaque Composition as a Predictor of Plaque Ulceration in Carotid Artery Atherosclerosis: The Plaque At RISK Study

Plaque Composition as a Predictor of Plaque Ulceration in Carotid Artery Atherosclerosis: The... ORIGINAL RESEARCH EXTRACRANIAL VASCULAR Plaque Composition as a Predictor of Plaque Ulceration in Carotid Artery Atherosclerosis: The Plaque At RISK Study K. Dilba, D.H.K. van Dam-Nolen, A.C. van Dijk, M. Kassem, A.F.W. van der Steen, P.J. Koudstaal, P.J. Nederkoorn, J. Hendrikse, M.E. Kooi, J.J. Wentzel, and A. van der Lugt ABSTRACT BACKGROUND AND PURPOSE: Plaque ulceration is a marker of previous plaque rupture. We studied the association between athe- rosclerotic plaque composition at baseline and plaque ulceration at baseline and follow-up. MATERIALS AND METHODS: We included symptomatic patients with a carotid stenosis of ,70% who underwent MDCTA and MR imaging at baseline (n¼ 180). MDCTA was repeated at 2 years (n¼ 73). We assessed the presence of ulceration using MDCTA. Baseline MR imaging was used to assess the vessel wall volume and the presence and volume of plaque components (intraplaque hemorrhage, lipid-rich necrotic core, and calcifications) and the fibrous cap status. Associations at baseline were evaluated with bi- nary logistic regression and reported with an OR and its 95% CI. Simple statistical testing was performed in the follow-up analysis. RESULTS: At baseline, the prevalence of plaque ulceration was 27% (49/180). Increased wall volume (OR ¼ 12.1; 95% CI, 3.5–42.0), http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png American Journal of Neuroradiology American Journal of Neuroradiology

Plaque Composition as a Predictor of Plaque Ulceration in Carotid Artery Atherosclerosis: The Plaque At RISK Study

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Publisher
American Journal of Neuroradiology
Copyright
© 2021 by American Journal of Neuroradiology
ISSN
0195-6108
eISSN
1936-959X
DOI
10.3174/ajnr.A6868
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Abstract

ORIGINAL RESEARCH EXTRACRANIAL VASCULAR Plaque Composition as a Predictor of Plaque Ulceration in Carotid Artery Atherosclerosis: The Plaque At RISK Study K. Dilba, D.H.K. van Dam-Nolen, A.C. van Dijk, M. Kassem, A.F.W. van der Steen, P.J. Koudstaal, P.J. Nederkoorn, J. Hendrikse, M.E. Kooi, J.J. Wentzel, and A. van der Lugt ABSTRACT BACKGROUND AND PURPOSE: Plaque ulceration is a marker of previous plaque rupture. We studied the association between athe- rosclerotic plaque composition at baseline and plaque ulceration at baseline and follow-up. MATERIALS AND METHODS: We included symptomatic patients with a carotid stenosis of ,70% who underwent MDCTA and MR imaging at baseline (n¼ 180). MDCTA was repeated at 2 years (n¼ 73). We assessed the presence of ulceration using MDCTA. Baseline MR imaging was used to assess the vessel wall volume and the presence and volume of plaque components (intraplaque hemorrhage, lipid-rich necrotic core, and calcifications) and the fibrous cap status. Associations at baseline were evaluated with bi- nary logistic regression and reported with an OR and its 95% CI. Simple statistical testing was performed in the follow-up analysis. RESULTS: At baseline, the prevalence of plaque ulceration was 27% (49/180). Increased wall volume (OR ¼ 12.1; 95% CI, 3.5–42.0),

Journal

American Journal of Neuroradiology – American Journal of Neuroradiology

Published: Jan 1, 2021

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