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Perfusion CT in Patients with Acute Ischemic Stroke Treated with Intra-Arterial Thrombolysis: Predictive Value of Infarct Core Size on Clinical Outcome

Perfusion CT in Patients with Acute Ischemic Stroke Treated with Intra-Arterial Thrombolysis:... This Article Figures Only Full Text Full Text (PDF) All Versions of this Article: ajnr.A1439v1 30/4/722 most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Gasparotti, R. Articles by Pezzini, A. Search for Related Content PubMed PubMed Citation Articles by Gasparotti, R. Articles by Pezzini, A. Hotlight (NEW!) What's Hotlight? American Journal of Neuroradiology 30:722-727, April 2009 © 2009 American Society of Neuroradiology BRAIN Perfusion CT in Patients with Acute Ischemic Stroke Treated with Intra-Arterial Thrombolysis: Predictive Value of Infarct Core Size on Clinical Outcome R. Gasparotti a , M. Grassi b , D. Mardighian a , M. Frigerio a , M. Pavia a , R. Liserre a , M. Magoni c , L. Mascaro d , A. Padovani e and A. Pezzini e a Dipartimento di Diagnostica per Immagini, Neuroradiologia, Università di Brescia, Brescia, Italy b Dipartimento di Scienze Sanitarie Applicate, Sezione di Statistica Medica e Epidemiologia, Università di Pavia, Pavia, Italy c Stroke Unit, Neurologia Vascolare, Spedali Civili di Brescia, Brescia, Italy d Dipartimento di Diagnostica per Immagini, Fisica Medica, Spedali Civili di Brescia, Brescia, Italy e Dipartimento di Scienze Mediche e Chirurgiche, Clinica Neurologica, Università degli Studi di Brescia, Brescia, Italy Please address correspondence to Roberto Gasparotti, MD, Dipartimento di Diagnostica per Immagini, Neuroradiologia, Università degli Studi di Brescia, P.le Spedali Civili, 1, 25100 Brescia, Italy; e-mail: gasparo@med.unibs.it BACKGROUND AND PURPOSE: A potential role of perfusion CT (PCT) in selecting patients with stroke for reperfusion therapies has been recently advocated. The purpose of the study was to assess the reliability of PCT in predicting clinical outcome of patients with acute ischemic stroke treated with intra-arterial thrombolysis (IAT). MATERIALS AND METHODS: Twenty-seven patients with acute hemispheric ischemic stroke were investigated with PCT and treated with IAT between 3 and 6 hours of stroke onset. The infarct core was outlined on cerebral blood volume (CBV) maps by using accepted viability thresholds. The penumbra was defined as time-to-peak (TTP)-CBV mismatch. Clinical outcome was assessed by modified Rankin Scale (mRS) scores at 3 months and dichotomized into favorable (mRS score, 0–2) and unfavorable (mRS score, 3–6). Data were retrospectively analyzed by multiple regression to identify predictors of clinical outcome among the following variables: age, sex, National Institutes of Health Stroke Scale score, serum glucose level, thrombolytic agent, infarct core and mismatch size, collateral circulation, time to recanalization, and recanalization rate after IAT. RESULTS: Patients with favorable outcome had smaller cores ( P = .03), increased mismatch ratios ( P = .03), smaller final infarct sizes ( P < .01), higher recanalization rates ( P = .03), and reduced infarct growth rates ( P < .01), compared with patients with unfavorable outcome. The core size was the strongest predictor of clinical outcome in an "all subset" model search ( P = .01; 0.96 point increase in mRS score per any increment of 1 SD; 95% confidence interval, +0.17 to +1.75). CONCLUSIONS: PCT is a reliable tool for the identification of irreversibly damaged brain tissue and for the prediction of clinical outcome of patients with acute stroke treated with IAT. Home Subscribe Author Instructions Submit Online Search the AJNR Archives Feedback Help Copyright © 2010 by the American Society of Neuroradiology. Print ISSN: 0195-6108 Online ISSN: 1936-959X http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png American Journal of Neuroradiology American Journal of Neuroradiology

Perfusion CT in Patients with Acute Ischemic Stroke Treated with Intra-Arterial Thrombolysis: Predictive Value of Infarct Core Size on Clinical Outcome

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Publisher
American Journal of Neuroradiology
Copyright
Copyright © 2010 by the American Society of Neuroradiology.
ISSN
0195-6108
eISSN
1936-959X
DOI
10.3174/ajnr.A1439
Publisher site
See Article on Publisher Site

Abstract

This Article Figures Only Full Text Full Text (PDF) All Versions of this Article: ajnr.A1439v1 30/4/722 most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Gasparotti, R. Articles by Pezzini, A. Search for Related Content PubMed PubMed Citation Articles by Gasparotti, R. Articles by Pezzini, A. Hotlight (NEW!) What's Hotlight? American Journal of Neuroradiology 30:722-727, April 2009 © 2009 American Society of Neuroradiology BRAIN Perfusion CT in Patients with Acute Ischemic Stroke Treated with Intra-Arterial Thrombolysis: Predictive Value of Infarct Core Size on Clinical Outcome R. Gasparotti a , M. Grassi b , D. Mardighian a , M. Frigerio a , M. Pavia a , R. Liserre a , M. Magoni c , L. Mascaro d , A. Padovani e and A. Pezzini e a Dipartimento di Diagnostica per Immagini, Neuroradiologia, Università di Brescia, Brescia, Italy b Dipartimento di Scienze Sanitarie Applicate, Sezione di Statistica Medica e Epidemiologia, Università di Pavia, Pavia, Italy c Stroke Unit, Neurologia Vascolare, Spedali Civili di Brescia, Brescia, Italy d Dipartimento di Diagnostica per Immagini, Fisica Medica, Spedali Civili di Brescia, Brescia, Italy e Dipartimento di Scienze Mediche e Chirurgiche, Clinica Neurologica, Università degli Studi di Brescia, Brescia, Italy Please address correspondence to Roberto Gasparotti, MD, Dipartimento di Diagnostica per Immagini, Neuroradiologia, Università degli Studi di Brescia, P.le Spedali Civili, 1, 25100 Brescia, Italy; e-mail: gasparo@med.unibs.it BACKGROUND AND PURPOSE: A potential role of perfusion CT (PCT) in selecting patients with stroke for reperfusion therapies has been recently advocated. The purpose of the study was to assess the reliability of PCT in predicting clinical outcome of patients with acute ischemic stroke treated with intra-arterial thrombolysis (IAT). MATERIALS AND METHODS: Twenty-seven patients with acute hemispheric ischemic stroke were investigated with PCT and treated with IAT between 3 and 6 hours of stroke onset. The infarct core was outlined on cerebral blood volume (CBV) maps by using accepted viability thresholds. The penumbra was defined as time-to-peak (TTP)-CBV mismatch. Clinical outcome was assessed by modified Rankin Scale (mRS) scores at 3 months and dichotomized into favorable (mRS score, 0–2) and unfavorable (mRS score, 3–6). Data were retrospectively analyzed by multiple regression to identify predictors of clinical outcome among the following variables: age, sex, National Institutes of Health Stroke Scale score, serum glucose level, thrombolytic agent, infarct core and mismatch size, collateral circulation, time to recanalization, and recanalization rate after IAT. RESULTS: Patients with favorable outcome had smaller cores ( P = .03), increased mismatch ratios ( P = .03), smaller final infarct sizes ( P < .01), higher recanalization rates ( P = .03), and reduced infarct growth rates ( P < .01), compared with patients with unfavorable outcome. The core size was the strongest predictor of clinical outcome in an "all subset" model search ( P = .01; 0.96 point increase in mRS score per any increment of 1 SD; 95% confidence interval, +0.17 to +1.75). CONCLUSIONS: PCT is a reliable tool for the identification of irreversibly damaged brain tissue and for the prediction of clinical outcome of patients with acute stroke treated with IAT. Home Subscribe Author Instructions Submit Online Search the AJNR Archives Feedback Help Copyright © 2010 by the American Society of Neuroradiology. Print ISSN: 0195-6108 Online ISSN: 1936-959X

Journal

American Journal of NeuroradiologyAmerican Journal of Neuroradiology

Published: Apr 1, 2009

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