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Perfusion CT Imaging of Brain Tumors: An Overview

Perfusion CT Imaging of Brain Tumors: An Overview SUMMARY: Perfusion imaging of brain tumors has been performed by using various tracer and nontracer modalities and can provide additional physiologic and hemodynamic information, which is not available with routine morphologic imaging. Tumor vascular perfusion parameters obtained by using CT or MR perfusion have been used for tumor grading, prognosis, and treatment response in addition to differentiating treatment/radiation effects and non-neoplastic lesions from neoplasms. This article is an overview of the utility of PCT for assessment of brain tumors and describes the technique, its advantages, and limitations. Abbreviations BBB blood-brain barrier CBF cerebral blood flow CBV cerebral blood volume DSC dynamic susceptibility contrast FDG-PET fluorodeoxyglucose–positron-emission tomography K trans volume transfer coefficient MRI MR imaging MTT mean transit time MVCP microvascular cellular proliferation MVD microvascular density PCT perfusion CT PS permeability surface-area product rCBV regional cerebral blood flow ROI region of interest rPSR relative percentage signal recovery SDF-1 stromal derived factor-1 TDL tumefactive demyelinating lesion TVA total vascular area VEGF vascular endothelial growth factor WHO World Health Organization http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png American Journal of Neuroradiology American Journal of Neuroradiology

Perfusion CT Imaging of Brain Tumors: An Overview

American Journal of Neuroradiology , Volume 32 (9): 1570 – Oct 1, 2011

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Publisher
American Journal of Neuroradiology
Copyright
Copyright © 2011 by the American Society of Neuroradiology.
ISSN
0195-6108
eISSN
1936-959X
DOI
10.3174/ajnr.A2263
pmid
21051510
Publisher site
See Article on Publisher Site

Abstract

SUMMARY: Perfusion imaging of brain tumors has been performed by using various tracer and nontracer modalities and can provide additional physiologic and hemodynamic information, which is not available with routine morphologic imaging. Tumor vascular perfusion parameters obtained by using CT or MR perfusion have been used for tumor grading, prognosis, and treatment response in addition to differentiating treatment/radiation effects and non-neoplastic lesions from neoplasms. This article is an overview of the utility of PCT for assessment of brain tumors and describes the technique, its advantages, and limitations. Abbreviations BBB blood-brain barrier CBF cerebral blood flow CBV cerebral blood volume DSC dynamic susceptibility contrast FDG-PET fluorodeoxyglucose–positron-emission tomography K trans volume transfer coefficient MRI MR imaging MTT mean transit time MVCP microvascular cellular proliferation MVD microvascular density PCT perfusion CT PS permeability surface-area product rCBV regional cerebral blood flow ROI region of interest rPSR relative percentage signal recovery SDF-1 stromal derived factor-1 TDL tumefactive demyelinating lesion TVA total vascular area VEGF vascular endothelial growth factor WHO World Health Organization

Journal

American Journal of NeuroradiologyAmerican Journal of Neuroradiology

Published: Oct 1, 2011

References

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