SUMMARY: Perfusion imaging of brain tumors has been performed by using various tracer and nontracer modalities and can provide additional physiologic and hemodynamic information, which is not available with routine morphologic imaging. Tumor vascular perfusion parameters obtained by using CT or MR perfusion have been used for tumor grading, prognosis, and treatment response in addition to differentiating treatment/radiation effects and non-neoplastic lesions from neoplasms. This article is an overview of the utility of PCT for assessment of brain tumors and describes the technique, its advantages, and limitations. Abbreviations BBB blood-brain barrier CBF cerebral blood flow CBV cerebral blood volume DSC dynamic susceptibility contrast FDG-PET fluorodeoxyglucose–positron-emission tomography K trans volume transfer coefficient MRI MR imaging MTT mean transit time MVCP microvascular cellular proliferation MVD microvascular density PCT perfusion CT PS permeability surface-area product rCBV regional cerebral blood flow ROI region of interest rPSR relative percentage signal recovery SDF-1 stromal derived factor-1 TDL tumefactive demyelinating lesion TVA total vascular area VEGF vascular endothelial growth factor WHO World Health Organization
American Journal of Neuroradiology – American Journal of Neuroradiology
Published: Oct 1, 2011
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