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Neuroradiologists, Be Mindful of the Neuroinvasive Potential of COVID-19

Neuroradiologists, Be Mindful of the Neuroinvasive Potential of COVID-19 LETTERS Neuroradiologists, Be Mindful of the Neuroinvasive Potential of COVID-19 he COVID-19 pandemic continues to have a far-reaching In the hematogenous route, the virus may pass through the BBB Timpact on nearly all aspects of society. First identified in by transcytosis across brain microvascular endothelial cells and December 2019 in Wuhan, the capital city of Hubei, China, pericytes by endocytic vesicles or, rather, directly infect endothelial COVID-19 is disseminated primarily via respiratory droplets and or epithelial cells to pass across the BBB or blood-CSF barrier has the potential to cause severe respiratory distress in vulnerable in the choroid plexus of the ventricular system, respectively. Alternatively, the virus could be transported intracellularly in a patients, resulting in pneumonia, acute respiratory distress syn- concealed manner by leukocytes. There is mixed evidence regard- drome (ARDS), multiorgan dysfunction, and death. Although ing the viability of the hematogenous route in the neuroinvasive- recent literature on the virus has centered on the respiratory ness of CoVs. On the one hand, it has been reported that SARS has manifestations of the disease, a multitude of studies during the the ability to directly infect the BBB epithelium, representing 1 ave- past few decades have shown that several http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png American Journal of Neuroradiology American Journal of Neuroradiology

Neuroradiologists, Be Mindful of the Neuroinvasive Potential of COVID-19

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Publisher
American Journal of Neuroradiology
Copyright
© 2020 by American Journal of Neuroradiology. Indicates open access to non-subscribers at www.ajnr.org
ISSN
0195-6108
eISSN
1936-959X
DOI
10.3174/ajnr.A6551
Publisher site
See Article on Publisher Site

Abstract

LETTERS Neuroradiologists, Be Mindful of the Neuroinvasive Potential of COVID-19 he COVID-19 pandemic continues to have a far-reaching In the hematogenous route, the virus may pass through the BBB Timpact on nearly all aspects of society. First identified in by transcytosis across brain microvascular endothelial cells and December 2019 in Wuhan, the capital city of Hubei, China, pericytes by endocytic vesicles or, rather, directly infect endothelial COVID-19 is disseminated primarily via respiratory droplets and or epithelial cells to pass across the BBB or blood-CSF barrier has the potential to cause severe respiratory distress in vulnerable in the choroid plexus of the ventricular system, respectively. Alternatively, the virus could be transported intracellularly in a patients, resulting in pneumonia, acute respiratory distress syn- concealed manner by leukocytes. There is mixed evidence regard- drome (ARDS), multiorgan dysfunction, and death. Although ing the viability of the hematogenous route in the neuroinvasive- recent literature on the virus has centered on the respiratory ness of CoVs. On the one hand, it has been reported that SARS has manifestations of the disease, a multitude of studies during the the ability to directly infect the BBB epithelium, representing 1 ave- past few decades have shown that several

Journal

American Journal of Neuroradiology – American Journal of Neuroradiology

Published: Jun 1, 2020

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