ORIGINAL RESEARCH SPINE MRI Atlas-Based Measurement of Spinal Cord Injury Predicts Outcome in Acute Flaccid Myelitis X D.B. McCoy, X J.F. Talbott, X Michael Wilson, X M.D. Mamlouk, X J. Cohen-Adad, X Mark Wilson, and X J. Narvid ABSTRACT BACKGROUND AND PURPOSE: Recent advances in spinal cord imaging analysis have led to the development of a robust anatomic template and atlas incorporated into an open-source platform referred to as the Spinal Cord Toolbox. Using the Spinal Cord Toolbox, we sought to correlate measures of GM, WM, and cross-sectional area pathology on T2 MR imaging with motor disability in patients with acute ﬂaccid myelitis. MATERIALS AND METHODS: Spinal cord imaging for 9 patients with acute ﬂaccid myelitis was analyzed by using the Spinal Cord Toolbox. A semiautomated pipeline using the Spinal Cord Toolbox measured lesion involvement in GM, WM, and total spinal cord cross-sectional area. ProportionsofGM,WM,andcross-sectionalareaaffectedbyT2hyperintensitywerecalculatedacross3ROIs:1)centeraxialsectionoflesion;2) full lesion segment; and 3) full cord atlas volume. Spearman rank order correlation was calculated to compare MR metrics with clinical measures of disability. RESULTS: Proportion of GM metrics at the center axial section signiﬁcantly correlated with measures of motor impairment upon admission (r 0.78; P .014) and at 3-month follow-up (r 0.66;
American Journal of Neuroradiology – American Journal of Neuroradiology
Published: Feb 1, 2017
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