LETTERS MR Imaging of the Olfactory Bulbs in Patients with COVID-19 and Anosmia: How to Avoid Misinterpretation e recently read the article entitled “Brain Imaging of Patients Wwith COVID-19: Findings at an Academic Institution dur- ing the Height of the Outbreak in New York City,” aretrospective neuroimaging cohort by Lin et al. The authors reported T2-FLAIR postgadolinium olfactory bulb (OB) signal abnormalities in 4 patients positive for coronavirus disease 2019 (COVID-19) with only 1 having documented anosmia. This finding was subsequently interpreted as olfactive neuritis and a correlate of the anosmia. Anosmia has been identified as one of the first or only recogniz- able symptoms of the Severe Acute Respiratory Syndrome corona- virus 2 (SARS-CoV-2) infection, accounting for .50% of Western FIG 1. 3T brain MR imaging in a healthy subject (A) and a patient with COVID-19–related anosmia (B). Coronal reformatted 3D FLAIR images patients. It is now known that post-SARS-CoV-1 anosmia could show OB hyperintensity (arrows) compared with the cortex in both persist for as long as 2 years. It, thus, becomes relevant to identify subjects. MR imaging biomarkers of OB involvement, including signal and volume changes, that might be predictive of the olfactory disorder Thus, the OBs
American Journal of Neuroradiology – American Journal of Neuroradiology
Published: Mar 1, 2021
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