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This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Knauth, M. Articles by Sartor, K. Search for Related Content PubMed PubMed Citation Articles by Knauth, M. Articles by Sartor, K. Hotlight (NEW!) What's Hotlight? American Journal of Neuroradiology, Vol 17, Issue 10 1853-1859, Copyright © 1996 by American Society of Neuroradiology ARTICLES MR enhancement of brain lesions: increased contrast dose compared with magnetization transfer M Knauth, M Forsting, M Hartmann, S Heiland, T Balzer and K Sartor Department of Neuroradiology, University of Heidelberg Medical School, Germany. PURPOSE: To compare image contrast and lesion conspicuity of enhancing intracranial lesions obtained with T1-weighted and magnetization transfer T1-weighted spin-echo sequences after administration of standard (0.1 mmol/kg body weight) and triple doses of gadobutrol. METHODS: Twenty-four patients with a total of 34 enhancing intracranial lesions were studied with T1-weighted and magnetization transfer T1- weighted spin-echo MR imaging. An incremental dose technique was used with intravenous injections of 0.1 and 0.2 mmol/kg body weight gadobutrol. Lesion-to-white matter contrast and white matter-to-edema contrast were calculated. RESULTS: The lesion-to-white matter contrast of the magnetization transfer T1-weighted studies was significantly higher than that of the T1-weighted studies when identical doses of gadobutrol were compared. The lesion-to-white matter contrast was not significantly different on the triple-dose T1-weighted study and the standard-dose magnetization transfer T1-weighted study. Two lesions were visible only on the standard-dose magnetization transfer T1- weighted and the triple-dose studies. CONCLUSION: Standard-dose magnetization transfer T1-weighted and triple-dose T1-weighted spin- echo MR studies are equally well suited to increase the lesion-to-white matter contrast in patients with enhancing intracranial lesions. Triple- dose magnetization transfer T1-weighted studies further increase lesion- to-white matter contrast but do not show additional lesions. This article has been cited by other articles: B. Tombach, C. Bremer, P. Reimer, F. Matzkies, R. M. Schaefer, W. Ebert, V. Geens, J. Eisele, and W. Heindel Using Highly Concentrated Gadobutrol as an MR Contrast Agent in Patients Also Requiring Hemodialysis: Safety and Dialysability Am. J. Roentgenol., January 1, 2002; 178(1): 105 - 109. Abstract Full Text PDF B. Tombach, C. Bremer, P. Reimer, K. Kisters, R. M. Schaefer, V. Geens, and W. Heindel Renal Tolerance of a Neutral Gadolinium Chelate (gadobutrol) in Patients with Chronic Renal Failure: Results of a Randomized Study Radiology, March 1, 2001; 218(3): 651 - 657. Abstract Full Text T. Sugahara, Y. Korogi, Y. Ge, Y. Shigematsu, L. Liang, K. Yoshizumi, M. Kitajima, and M. Takahashi Contrast Enhancement of Intracranial Lesions: Conventional T1-Weighted Spin-Echo versus Fast Spin-Echo MR Imaging Techniques AJNR Am. J. Neuroradiol., September 1, 1999; 20(8): 1554 - 1559. Abstract Full Text Home Subscribe Author Instructions Submit Online Search the AJNR Archives Feedback Help Copyright © 2010 by the American Society of Neuroradiology. Print ISSN: 0195-6108 Online ISSN: 1936-959X
American Journal of Neuroradiology – American Journal of Neuroradiology
Published: Nov 1, 1996
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