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Measurement of Cortical Thickness and Volume of Subcortical Structures in Multiple Sclerosis: Agreement between 2D Spin-Echo and 3D MPRAGE T1-Weighted Images

Measurement of Cortical Thickness and Volume of Subcortical Structures in Multiple Sclerosis:... ORIGINAL RESEARCH ADULT BRAIN Measurement of Cortical Thickness and Volume of Subcortical Structures in Multiple Sclerosis: Agreement between 2D Spin-Echo and 3D MPRAGE T1-Weighted Images X A. Vidal-Jordana, X D. Pareto, X J. Sastre-Garriga, X C. Auger, X E. Ciampi, X X. Montalban, and X A. Rovira ABSTRACT BACKGROUND AND PURPOSE: Gray matter pathology is known to occur in multiple sclerosis and is related to disease outcomes. FreeSurfer and the FMRIB Integrated Registration and Segmentation Tool (FIRST) have been developed for measuring cortical and subcortical gray matter in 3D-gradient-echo T1-weighted images. Unfortunately, most historical MS cohorts do not have 3D-gradient- echo, but 2D-spin-echo images instead. We aimed to evaluate whether cortical thickness and the volume of subcortical structures measured with FreeSurfer and FIRST could be reliably measured in 2D-spin-echo images and to investigate the strength and direction of clinicoradiologic correlations. MATERIALS AND METHODS: Thirty-eight patients with MS and 2D-spin-echo and 3D-gradient-echo T1-weighted images obtained at the same time were analyzed by using FreeSurfer and FIRST. The intraclass correlation coefficient between the estimates was obtained. Correlation coefficients were used to investigate clinicoradiologic associations. RESULTS: SubcorticalvolumesobtainedwithbothFreeSurferandFIRSTshowedgoodagreementbetween2D-spin-echoand3D-gradient-echo images,with68.8%–76.2%ofthestructureshavingeitherasubstantialoralmostperfectagreement.Nevertheless,withFIRSTwith2D-spin-echo, 18%ofpatientshadmis-segmentation.Corticalthicknesshadthelowestintraclasscorrelationcoefficientvalues,withonly1structure(1.4%)having substantial agreement. Disease duration and the Expanded Disability Status Scale showed a moderate http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png American Journal of Neuroradiology American Journal of Neuroradiology

Measurement of Cortical Thickness and Volume of Subcortical Structures in Multiple Sclerosis: Agreement between 2D Spin-Echo and 3D MPRAGE T1-Weighted Images

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Publisher
American Journal of Neuroradiology
Copyright
© 2017 by American Journal of Neuroradiology
ISSN
0195-6108
eISSN
1936-959X
DOI
10.3174/ajnr.A4999
pmid
27884876
Publisher site
See Article on Publisher Site

Abstract

ORIGINAL RESEARCH ADULT BRAIN Measurement of Cortical Thickness and Volume of Subcortical Structures in Multiple Sclerosis: Agreement between 2D Spin-Echo and 3D MPRAGE T1-Weighted Images X A. Vidal-Jordana, X D. Pareto, X J. Sastre-Garriga, X C. Auger, X E. Ciampi, X X. Montalban, and X A. Rovira ABSTRACT BACKGROUND AND PURPOSE: Gray matter pathology is known to occur in multiple sclerosis and is related to disease outcomes. FreeSurfer and the FMRIB Integrated Registration and Segmentation Tool (FIRST) have been developed for measuring cortical and subcortical gray matter in 3D-gradient-echo T1-weighted images. Unfortunately, most historical MS cohorts do not have 3D-gradient- echo, but 2D-spin-echo images instead. We aimed to evaluate whether cortical thickness and the volume of subcortical structures measured with FreeSurfer and FIRST could be reliably measured in 2D-spin-echo images and to investigate the strength and direction of clinicoradiologic correlations. MATERIALS AND METHODS: Thirty-eight patients with MS and 2D-spin-echo and 3D-gradient-echo T1-weighted images obtained at the same time were analyzed by using FreeSurfer and FIRST. The intraclass correlation coefficient between the estimates was obtained. Correlation coefficients were used to investigate clinicoradiologic associations. RESULTS: SubcorticalvolumesobtainedwithbothFreeSurferandFIRSTshowedgoodagreementbetween2D-spin-echoand3D-gradient-echo images,with68.8%–76.2%ofthestructureshavingeitherasubstantialoralmostperfectagreement.Nevertheless,withFIRSTwith2D-spin-echo, 18%ofpatientshadmis-segmentation.Corticalthicknesshadthelowestintraclasscorrelationcoefficientvalues,withonly1structure(1.4%)having substantial agreement. Disease duration and the Expanded Disability Status Scale showed a moderate

Journal

American Journal of Neuroradiology – American Journal of Neuroradiology

Published: Feb 1, 2017

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