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Fully-Automated Quantification of Regional Brain Volumes for Improved Detection of Focal Atrophy in Alzheimer Disease

Fully-Automated Quantification of Regional Brain Volumes for Improved Detection of Focal Atrophy... This Article Free to Access Figures Only Full Text Full Text (PDF) Supplemental Online Movie All Versions of this Article: ajnr.A1402v1 ajnr.A1402v2 30/3/578 most recent Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Brewer, J.B. Articles by Smith, M.E. Search for Related Content PubMed PubMed Citation Articles by Brewer, J.B. Articles by Smith, M.E. Hotlight (NEW!) What's Hotlight? American Journal of Neuroradiology 30:578-580, March 2009 © 2009 American Society of Neuroradiology Technical Note BRAIN Fully-Automated Quantification of Regional Brain Volumes for Improved Detection of Focal Atrophy in Alzheimer Disease J.B. Brewer a , S. Magda b , C. Airriess b and M.E. Smith b a Department of Radiology and Neurosciences, University of California, San Diego, San Diego, Calif b Department of CorTechs Labs, La Jolla, Calif Please address correspondence to James B. Brewer, MD, PhD, Human Memory Laboratory, University of California, San Diego, 9500 Gilman Dr, MC 0949, La Jolla, CA 92093; e-mail: jbrewer@ucsd.edu SUMMARY: Volumetric analysis of structural MR images of the brain may provide quantitative evidence of neurodegeneration and help identify patients at risk for rapid clinical deterioration. This note describes tests of a fully automated MR imaging postprocessing system for volumetric analysis of structures (such as the hippocampus) known to be affected in early Alzheimer disease (AD). The system yielded results that correlated highly with independent computer-aided manual segmentation and were sensitive to the anatomic atrophy characteristic of mild AD. Home Subscribe Author Instructions Submit Online Search the AJNR Archives Feedback Help Copyright © 2010 by the American Society of Neuroradiology. Print ISSN: 0195-6108 Online ISSN: 1936-959X http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png American Journal of Neuroradiology American Journal of Neuroradiology

Fully-Automated Quantification of Regional Brain Volumes for Improved Detection of Focal Atrophy in Alzheimer Disease

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Publisher
American Journal of Neuroradiology
Copyright
Copyright © 2010 by the American Society of Neuroradiology.
ISSN
0195-6108
eISSN
1936-959X
DOI
10.3174/ajnr.A1402
Publisher site
See Article on Publisher Site

Abstract

This Article Free to Access Figures Only Full Text Full Text (PDF) Supplemental Online Movie All Versions of this Article: ajnr.A1402v1 ajnr.A1402v2 30/3/578 most recent Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Brewer, J.B. Articles by Smith, M.E. Search for Related Content PubMed PubMed Citation Articles by Brewer, J.B. Articles by Smith, M.E. Hotlight (NEW!) What's Hotlight? American Journal of Neuroradiology 30:578-580, March 2009 © 2009 American Society of Neuroradiology Technical Note BRAIN Fully-Automated Quantification of Regional Brain Volumes for Improved Detection of Focal Atrophy in Alzheimer Disease J.B. Brewer a , S. Magda b , C. Airriess b and M.E. Smith b a Department of Radiology and Neurosciences, University of California, San Diego, San Diego, Calif b Department of CorTechs Labs, La Jolla, Calif Please address correspondence to James B. Brewer, MD, PhD, Human Memory Laboratory, University of California, San Diego, 9500 Gilman Dr, MC 0949, La Jolla, CA 92093; e-mail: jbrewer@ucsd.edu SUMMARY: Volumetric analysis of structural MR images of the brain may provide quantitative evidence of neurodegeneration and help identify patients at risk for rapid clinical deterioration. This note describes tests of a fully automated MR imaging postprocessing system for volumetric analysis of structures (such as the hippocampus) known to be affected in early Alzheimer disease (AD). The system yielded results that correlated highly with independent computer-aided manual segmentation and were sensitive to the anatomic atrophy characteristic of mild AD. Home Subscribe Author Instructions Submit Online Search the AJNR Archives Feedback Help Copyright © 2010 by the American Society of Neuroradiology. Print ISSN: 0195-6108 Online ISSN: 1936-959X

Journal

American Journal of NeuroradiologyAmerican Journal of Neuroradiology

Published: Mar 1, 2009

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