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Fetal and Neonatal MRI Predictors of Aggressive Early Clinical Course in Vein of Galen Malformation

Fetal and Neonatal MRI Predictors of Aggressive Early Clinical Course in Vein of Galen Malformation ORIGINAL RESEARCH PEDIATRICS Fetal and Neonatal MRI Predictors of Aggressive Early Clinical Course in Vein of Galen Malformation L. Arko, M. Lambrych, A. Montaser, D Zurakowski, and D.B. Orbach ABSTRACT BACKGROUND AND PURPOSE: Neonates with vein of Galen malformations are split into 2 cohorts: one needing urgent neonatal embolization, with relatively high mortality and morbidity even with expert care, and a cohort in which embolization can be deferred until infancy, with far better prognosis. We aimed to identify brain MR imaging characteristics obtained from fetal and early neonatal scans that can predict the clinical presentation. MATERIALS AND METHODS: Patients with vein of Galen malformations were stratified into a neonatal at-risk cohort if the patient needed urgent neonatal intervention or if neonatal death occurred; or an infantile treatment cohort if they were stable enough not to require treatment until .1 month of age. Twelve vascular MR imaging parameters, measured by 2 independent observers, were systematically correlated with the need for early neonatal intervention and/or neonatal mortality. RESULTS: A total of 32 neonatal patients (21 patients in the neonatal at-risk cohort, 11 in the infantile treatment cohort) were identified. Maximal mediolateral diameter (area under the curve ¼ 0.866, P, .001) and http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png American Journal of Neuroradiology American Journal of Neuroradiology

Fetal and Neonatal MRI Predictors of Aggressive Early Clinical Course in Vein of Galen Malformation

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References (15)

Publisher
American Journal of Neuroradiology
Copyright
© 2020 by American Journal of Neuroradiology
ISSN
0195-6108
eISSN
1936-959X
DOI
10.3174/ajnr.A6585
Publisher site
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Abstract

ORIGINAL RESEARCH PEDIATRICS Fetal and Neonatal MRI Predictors of Aggressive Early Clinical Course in Vein of Galen Malformation L. Arko, M. Lambrych, A. Montaser, D Zurakowski, and D.B. Orbach ABSTRACT BACKGROUND AND PURPOSE: Neonates with vein of Galen malformations are split into 2 cohorts: one needing urgent neonatal embolization, with relatively high mortality and morbidity even with expert care, and a cohort in which embolization can be deferred until infancy, with far better prognosis. We aimed to identify brain MR imaging characteristics obtained from fetal and early neonatal scans that can predict the clinical presentation. MATERIALS AND METHODS: Patients with vein of Galen malformations were stratified into a neonatal at-risk cohort if the patient needed urgent neonatal intervention or if neonatal death occurred; or an infantile treatment cohort if they were stable enough not to require treatment until .1 month of age. Twelve vascular MR imaging parameters, measured by 2 independent observers, were systematically correlated with the need for early neonatal intervention and/or neonatal mortality. RESULTS: A total of 32 neonatal patients (21 patients in the neonatal at-risk cohort, 11 in the infantile treatment cohort) were identified. Maximal mediolateral diameter (area under the curve ¼ 0.866, P, .001) and

Journal

American Journal of Neuroradiology – American Journal of Neuroradiology

Published: Jun 1, 2020

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