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Excitotoxicity in Acute Encephalopathy with Biphasic Seizures and Late Reduced Diffusion

Excitotoxicity in Acute Encephalopathy with Biphasic Seizures and Late Reduced Diffusion This Article Free to Access Figures Only Full Text Full Text (PDF) All Versions of this Article: ajnr.A1247v1 30/1/132 most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Takanashi, J. Articles by Barkovich, A.J. Search for Related Content PubMed PubMed Citation Articles by Takanashi, J. Articles by Barkovich, A.J. Hotlight (NEW!) What's Hotlight? American Journal of Neuroradiology 30:132-135, January 2009 © 2009 American Society of Neuroradiology Case Report PEDIATRICS Excitotoxicity in Acute Encephalopathy with Biphasic Seizures and Late Reduced Diffusion J. Takanashi a , H. Tada a , H. Terada b and A.J. Barkovich c a Department of Pediatrics, Kameda Medical Center, Kamogawa, Japan b Department of Radiology, Toho University Sakura Medical Center, Sakura, Japan c Neuroradiology Section, Department of Radiology, University of California, San Francisco, San Francisco, Calif Please address correspondence to Jun-ichi Takanashi, MD, Department of Pediatrics, Kameda Medical Center, 929 Higashi-cho, Kamogawa-shi, Chiba 296-8602, Japan; e-mail: jtaka@kameda.jp SUMMARY: Acute encephalopathy with biphasic seizures and late reduced diffusion (AESD) is a recently described clinicoradiologic syndrome. MR spectroscopy in 3 patients with AESD revealed decreased N -acetylaspartate (NAA) and elevated glutamine/glutamate complex (Glx) during the week of presentation. Afterward, Glx normalized, whereas NAA remained low in 2 patients with neurologic sequelae but nearly normalized in the third patient without neurologic sequelae. These findings support the hypothesis that excitotoxic neuronal damage plays an important role in the pathogenesis of AESD and suggest that MR spectroscopy might be predictive of outcome. This article has been cited by other articles: A. Okumura, H. Kidokoro, T. Tsuji, M. Suzuki, T. Kubota, T. Kato, M. Komatsu, T. Shono, F. Hayakawa, T. Shimizu, et al. Differences of Clinical Manifestations According to the Patterns of Brain Lesions in Acute Encephalopathy with Reduced Diffusion in the Bilateral Hemispheres AJNR Am. J. Neuroradiol., April 1, 2009; 30(4): 825 - 830. Abstract Full Text PDF Home Subscribe Author Instructions Submit Online Search the AJNR Archives Feedback Help Copyright © 2010 by the American Society of Neuroradiology. Print ISSN: 0195-6108 Online ISSN: 1936-959X http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png American Journal of Neuroradiology American Journal of Neuroradiology

Excitotoxicity in Acute Encephalopathy with Biphasic Seizures and Late Reduced Diffusion

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Publisher
American Journal of Neuroradiology
Copyright
Copyright © 2010 by the American Society of Neuroradiology.
ISSN
0195-6108
eISSN
1936-959X
DOI
10.3174/ajnr.A1247
Publisher site
See Article on Publisher Site

Abstract

This Article Free to Access Figures Only Full Text Full Text (PDF) All Versions of this Article: ajnr.A1247v1 30/1/132 most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Takanashi, J. Articles by Barkovich, A.J. Search for Related Content PubMed PubMed Citation Articles by Takanashi, J. Articles by Barkovich, A.J. Hotlight (NEW!) What's Hotlight? American Journal of Neuroradiology 30:132-135, January 2009 © 2009 American Society of Neuroradiology Case Report PEDIATRICS Excitotoxicity in Acute Encephalopathy with Biphasic Seizures and Late Reduced Diffusion J. Takanashi a , H. Tada a , H. Terada b and A.J. Barkovich c a Department of Pediatrics, Kameda Medical Center, Kamogawa, Japan b Department of Radiology, Toho University Sakura Medical Center, Sakura, Japan c Neuroradiology Section, Department of Radiology, University of California, San Francisco, San Francisco, Calif Please address correspondence to Jun-ichi Takanashi, MD, Department of Pediatrics, Kameda Medical Center, 929 Higashi-cho, Kamogawa-shi, Chiba 296-8602, Japan; e-mail: jtaka@kameda.jp SUMMARY: Acute encephalopathy with biphasic seizures and late reduced diffusion (AESD) is a recently described clinicoradiologic syndrome. MR spectroscopy in 3 patients with AESD revealed decreased N -acetylaspartate (NAA) and elevated glutamine/glutamate complex (Glx) during the week of presentation. Afterward, Glx normalized, whereas NAA remained low in 2 patients with neurologic sequelae but nearly normalized in the third patient without neurologic sequelae. These findings support the hypothesis that excitotoxic neuronal damage plays an important role in the pathogenesis of AESD and suggest that MR spectroscopy might be predictive of outcome. This article has been cited by other articles: A. Okumura, H. Kidokoro, T. Tsuji, M. Suzuki, T. Kubota, T. Kato, M. Komatsu, T. Shono, F. Hayakawa, T. Shimizu, et al. Differences of Clinical Manifestations According to the Patterns of Brain Lesions in Acute Encephalopathy with Reduced Diffusion in the Bilateral Hemispheres AJNR Am. J. Neuroradiol., April 1, 2009; 30(4): 825 - 830. Abstract Full Text PDF Home Subscribe Author Instructions Submit Online Search the AJNR Archives Feedback Help Copyright © 2010 by the American Society of Neuroradiology. Print ISSN: 0195-6108 Online ISSN: 1936-959X

Journal

American Journal of NeuroradiologyAmerican Journal of Neuroradiology

Published: Jan 1, 2009

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