Access the full text.
Sign up today, get DeepDyve free for 14 days.
C. Blahak, Hansjoerg Baezner, L. Pantoni, A. Poggesi, Hugues Chabriat, T. Erkinjuntti, F. Fazekas, José Ferro, Peter Langhorne, John O'Brien, M. Visser, L. Wahlund, G. Waldemar, Anders Wallin, D. Inzitari, M. Hennerici (2009)
Deep frontal and periventricular age related white matter changes but not basal ganglia and infratentorial hyperintensities are associated with falls: cross sectional results from the LADIS studyJournal of Neurology, Neurosurgery, and Psychiatry, 80
S. Debette, S. Bombois, A. Bruandet, X. Delbeuck, Samuel Lepoittevin, C. Delmaire, D. Leys, F. Pasquier (2007)
Subcortical Hyperintensities Are Associated With Cognitive Decline in Patients With Mild Cognitive ImpairmentStroke, 38
S. Tekin, J. Cummings (2002)
Frontal-subcortical neuronal circuits and clinical neuropsychiatry: an update.Journal of psychosomatic research, 53 2
R. Victor, R. Haley, D. Willett, R. Peshock, Patrice Vaeth, D. Leonard, M. Basit, R. Cooper, V. Iannacchione, W. Visscher, Jennifer Staab, H. Hobbs (2004)
The Dallas Heart Study: a population-based probability sample for the multidisciplinary study of ethnic differences in cardiovascular health.The American journal of cardiology, 93 12
Marvin Nelson, Ignacio Gonzalez-Gomez, Floyd Gilles (1991)
Dyke Award. The search for human telencephalic ventriculofugal arteries.AJNR. American journal of neuroradiology, 12 2
M. Woolrich, S. Jbabdi, B. Patenaude, M. Chappell, S. Makni, Timothy Behrens, C. Beckmann, M. Jenkinson, Stephen Smith (2009)
Bayesian analysis of neuroimaging data in FSLNeuroImage, 45
A. Gouw, W. Flier, E. Straaten, F. Barkhof, José Ferro, H. Baezner, L. Pantoni, D. Inzitari, T. Erkinjuntti, L. Wahlund, G. Waldemar, R. Schmidt, F. Fazekas, P. Scheltens (2006)
Simple versus complex assessment of white matter hyperintensities in relation to physical performance and cognition: the LADIS studyJournal of Neurology, 253
D. Heuvel, A. Spilt, VH Dam, E. Bollen, A.J.M. Craen, G. Blauw, F. Admiraal-Behloul, L. Launer, Acgm Es, R. Westendorp, WM Palm, M. Buchem (2006)
Measuring longitudinal white matter changes: comparison of a visual rating scale with a volumetric measurement.AJNR. American journal of neuroradiology, 27 4
P. Scheltens, F. Barkhof, D. Leys, E. Wolters, R. Ravid, W. Kamphorst (1995)
Histopathologic correlates of white matter changes on MRI in Alzheimer's disease and normal agingNeurology, 45
P. Maillard, E. Fletcher, D. Harvey, Owen Carmichael, B. Reed, D. Mungas, C. DeCarli (2011)
White Matter Hyperintensity PenumbraStroke, 42
H. Baezner, C. Blahak, A. Poggesi, L. Pantoni, D. Inzitari, H. Chabriat, T. Erkinjuntti, F. Fazekas, J. Ferro, P. Langhorne, John O'Brien, P. Scheltens, Marjolein Visser, L. Wahlund, G. Waldemar, A. Wallin, M. Hennerici (2008)
Association of gait and balance disorders with age-related white matter changesNeurology, 70
F. Yetkin, V. Haughton, M. Fischer, R. Papke, D. Daniels, L. Mark, L. Hendrix, R. Asleson, J. Johansen (1992)
High-signal foci on MR images of the brain: observer variability in their quantification.AJR. American journal of roentgenology, 159 1
F. Fazekas, J. Chawluk, A. Alavi, H. Hurtig, R. Zimmerman (1987)
MR signal abnormalities at 1.5 T in Alzheimer's dementia and normal aging.AJR. American journal of roentgenology, 149 2
J. Oosterman, Joseph Sergeant, Henry Weinstein, E. Scherder (2004)
Timed Executive Functions and White Matter in Aging With and Without Cardiovascular Risk FactorsReviews in the Neurosciences, 15
Z. Nasreddine, N. Phillips, H. Chertkow (2012)
Normative data for the Montreal Cognitive Assessment (MoCA) in a population-based sampleNeurology, 78
H. Nonaka, M. Akima, T. Hatori, T. Nagayama, Zean Zhang, F. Ihara (2003)
Microvasculature of the human cerebral white matter: Arteries of the deep white matterNeuropathology, 23
Keith Hulsey, Mohit Gupta, K. King, R. Peshock, A. Whittemore, R. Mccoll (2012)
Automated quantification of white matter disease extent at 3 T: Comparison with volumetric readingsJournal of Magnetic Resonance Imaging, 36
D. Inzitari, M. Simoni, G. Pracucci, A. Poggesi, A. Basile, H. Chabriat, T. Erkinjuntti, F. Fazekas, J. Ferro, M. Hennerici, P. Langhorne, J. O'Brien, F. Barkhof, M. Visser, L. Wahlund, G. Waldemar, A. Wallin, L. Pantoni (2007)
Risk of rapid global functional decline in elderly patients with severe cerebral age-related white matter changes: the LADIS study.Archives of internal medicine, 167 1
D. Heuvel, V. Dam, A. Craen, F. Admiraal-Behloul, H. Olofsen, E. Bollen, J. Jolles, Heather Murray, G. Blauw, R. Westendorp, M. Buchem (2006)
Increase in periventricular white matter hyperintensities parallels decline in mental processing speed in a non-demented elderly populationJournal of Neurology, Neurosurgery & Psychiatry, 77
Faith Gunning-Dixon, N. Raz (2000)
The cognitive correlates of white matter abnormalities in normal aging: a quantitative review.Neuropsychology, 14 2
E. Dijk, N. Prins, H. Vrooman, A. Hofman, P. Koudstaal, M. Breteler (2008)
Progression of Cerebral Small Vessel Disease in Relation to Risk Factors and Cognitive Consequences: Rotterdam Scan StudyStroke, 39
D. Moody, M. Bell, V. Challa (1990)
Features of the cerebral vascular pattern that predict vulnerability to perfusion or oxygenation deficiency: an anatomic study.AJNR. American journal of neuroradiology, 11 3
J. Fleiss (1971)
Measuring nominal scale agreement among many raters.Psychological Bulletin, 76
Stephen Smith, M. Jenkinson, M. Woolrich, C. Beckmann, Timothy Behrens, H. Johansen-Berg, P. Bannister, M. Luca, I. Drobnjak, D. Flitney, R. Niazy, James Saunders, J. Vickers, Yongyue Zhang, N. Stefano, J. Brady, P. Matthews (2004)
Advances in functional and structural MR image analysis and implementation as FSLNeuroImage, 23
J. Schmahmann, D. Pandya, Ruopeng Wang, G. Dai, H. D'Arceuil, A. Crespigny, V. Wedeen (2007)
Association fibre pathways of the brain: parallel observations from diffusion spectrum imaging and autoradiography.Brain : a journal of neurology, 130 Pt 3
N. Prins, E. Dijk, T. Heijer, S. Vermeer, J. Jolles, P. Koudstaal, A. Hofman, M. Breteler (2005)
Cerebral small-vessel disease and decline in information processing speed, executive function and memory.Brain : a journal of neurology, 128 Pt 9
C. DeCarli, E. Fletcher, Vincent Ramey, D. Harvey, W. Jagust (2005)
Anatomical Mapping of White Matter Hyperintensities (WMH): Exploring the Relationships Between Periventricular WMH, Deep WMH, and Total WMH BurdenStroke, 36
F. Fazekas, R. Kleinert, H. Offenbacher, R. Schmidt, G. Kleinert, F. Payer, H. Radner, H. Lechner (1993)
Pathologic correlates of incidental MRI white matter signal hyperintensitiesNeurology, 43
Mohit Neema, Z. Guss, J. Stankiewicz, A. Arora, B. Healy, R. Bakshi (2009)
Normal Findings on Brain Fluid-Attenuated Inversion Recovery MR Images at 3TAmerican Journal of Neuroradiology, 30
J. Wardlaw, Karen Ferguson, C. Graham (2004)
White matter hyperintensities and rating scales—observer reliability varies with lesion loadJournal of Neurology, 251
P. Kapeller, R. Barber, R. Vermeulen, H. Adèr, P. Scheltens, W. Freidl, O. Almkvist, M. Moretti, T. Ser, P. Vaghfeldt, C. Enzinger, F. Barkhof, D. Inzitari, T. Erkinjunti, R. Schmidt, F. Fazekas (2003)
Visual Rating of Age-Related White Matter Changes on Magnetic Resonance Imaging: Scale Comparison, Interrater Agreement, and Correlations With Quantitative MeasurementsStroke: Journal of the American Heart Association, 34
Z. Nasreddine, N. Phillips, Valérie Bédirian, S. Charbonneau, V. Whitehead, Isabelle Collin, J. Cummings, H. Chertkow (2005)
The Montreal Cognitive Assessment, MoCA: A Brief Screening Tool For Mild Cognitive ImpairmentJournal of the American Geriatrics Society, 53
M. Tullberg, E. Fletcher, C. DeCarli, D. Mungas, B. Reed, Danielle Harvey, M. Weiner, H. Chui, W. Jagust (2004)
White matter lesions impair frontal lobe function regardless of their locationNeurology, 63
D. Libon, C. Price, T. Giovannetti, R. Swenson, Brianne Bettcher, K. Heilman, A. Pennisi (2008)
Linking MRI Hyperintensities With Patterns of Neuropsychological Impairment: Evidence for a Threshold EffectStroke, 39
D. Salat, D. Salat, D. Tuch, D. Tuch, A. Kouwe, A. Kouwe, Douglas Greve, Douglas Greve, Vasanth Pappu, Vasanth Pappu, Stephanie Lee, Stephanie Lee, N. Hevelone, N. Hevelone, A. Zaleta, A. Zaleta, J. Growdon, S. Corkin, B. Fischl, B. Fischl, H. Rosas, H. Rosas (2010)
White matter pathology isolates the hippocampal formation in Alzheimer's diseaseNeurobiology of Aging, 31
(2013)
AJNR Am J Neuroradiol
S. Debette, H. Markus (2010)
The clinical importance of white matter hyperintensities on brain magnetic resonance imaging: systematic review and meta-analysisThe BMJ, 341
BACKGROUND AND PURPOSE: Age-related white matter hyperintensities have prognostic implications, but no accepted clinical standard exists for their assessment. We propose a simple objective visual rating system by using 3T brain MR imaging. MATERIALS AND METHODS: MR imaging from 559 participants was processed by using an automated method to determine WMH volumes and evaluated with a new visual rating scale based on the single largest WMH lesion diameter regardless of location. The reproducibility of the visual system was assessed. The association of WMH visual scores and automated volumes was then compared with cognitive scores from the Montreal Cognitive Assessment, which was available for 510 participants. RESULTS: Inter-reader reproducibility was good for subsamples with both high ( n = 52) and low ( n = 40) prevalence of large automated WMH volumes (agreement of 67% and 87.5%, κ = 0.71 and 0.76, respectively). Correlation between increased WMH and cognitive deficit measurements was equal for our visual ratings and automated volumes (Spearman ρ = 0.118 and 0.109; P values = 0.008 and 0.014, respectively). The visual scale retained a significant association with MoCA score after adjusting for age, sex, and education (standardized β = −0.087, P = .042). CONCLUSIONS: We propose a simple visual WMH scoring system suitable for use as a baseline evaluation in clinical practice. ABBREVIATIONS: MoCA Montreal Cognitive Assessment WMH white matter hyperintensity
American Journal of Neuroradiology – American Journal of Neuroradiology
Published: Apr 1, 2013
Read and print from thousands of top scholarly journals.
Already have an account? Log in
Bookmark this article. You can see your Bookmarks on your DeepDyve Library.
To save an article, log in first, or sign up for a DeepDyve account if you don’t already have one.
Copy and paste the desired citation format or use the link below to download a file formatted for EndNote
Access the full text.
Sign up today, get DeepDyve free for 14 days.
All DeepDyve websites use cookies to improve your online experience. They were placed on your computer when you launched this website. You can change your cookie settings through your browser.