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Endovascular Histologic Effects of Ultrathin Gold- or Vitronectin-Coated Platinum Aneurysm Coils in a Rodent Arterial Occlusion Model: A Preliminary Investigation

Endovascular Histologic Effects of Ultrathin Gold- or Vitronectin-Coated Platinum Aneurysm Coils... This Article Figures Only Full Text Full Text (PDF) All Versions of this Article: ajnr.A1368v1 30/1/85 most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Whitlow, C.T. Articles by Morris, P.P. Search for Related Content PubMed PubMed Citation Articles by Whitlow, C.T. Articles by Morris, P.P. Hotlight (NEW!) What's Hotlight? American Journal of Neuroradiology 30:85-90, January 2009 © 2009 American Society of Neuroradiology INTERVENTIONAL Endovascular Histologic Effects of Ultrathin Gold- or Vitronectin-Coated Platinum Aneurysm Coils in a Rodent Arterial Occlusion Model: A Preliminary Investigation C.T. Whitlow a , C.P. Geer a , C.W.T. Mattern a , B.J. Mussat-Whitlow d , S.K. Yazdani b , J.L. Berry b , J.H. Lalli e , R.O. Claus e , V.R. Challa c and P.P. Morris a a Departments of Radiology, Wake Forest University School of Medicine, Winston-Salem, NC b Departments of Biomedical Engineering, Wake Forest University School of Medicine, Winston-Salem, NC c Departments of Pathology, Wake Forest University School of Medicine, Winston-Salem, NC d Division of Institutional Planning, Assessment, and Research, Winston-Salem State University, Winston-Salem, NC e NanoSonic Inc, Blacksburg, Va Please address correspondence to P. Pearse Morris, MD, Division of Radiologic Sciences, Department of Radiology, Wake Forest University School of Medicine, Medical Center Blvd, Winston-Salem, NC; e-mail: pmorris@wfubmc.edu BACKGROUND AND PURPOSE: Novel stratagems to improve the efficacy of platinum coils in occluding cerebral aneurysms have primarily involved coating coils with materials thought likely to provoke more desirable histologic reactions. No investigations to date, however, have evaluated the utility of gold or vitronectin coatings, despite known endovascular histologic effects of these agents, which may be favorable for treating cerebral aneurysms. This study was conducted to evaluate the degree of endovascular histologic change associated with ultrathin gold- or vitronectin-coated platinum coils. It was hypothesized that such coatings would increase intra-aneurysmal intimal hyperplasia and the degree of luminal occlusion compared with standard platinum coils. MATERIALS AND METHODS: The ligated carotid artery rat model was used to study 4 different aneurysm coil conditions: no coil (sham-surgery controls), uncoated platinum coil, and gold- or vitronectin-coated platinum coil. Two weeks postimplantation, the aneurysms were harvested and stained with hematoxylin-eosin. Slides were evaluated for the degree of neointimal response by a pathologist blinded to treatment. Additional quantitative evaluation was performed blindly by using the ratio of intimal-to-luminal cross-sectional area. RESULTS: A gold- or vitronectin-coated platinum aneurysm coil produced a statistically significant increase in neointimal response compared with a sham (no coil). Arterial segments treated with gold-coated platinum coils also demonstrated a statistically significant 100% increase in neointimal response compared with those treated with bare platinum coils. CONCLUSIONS: In concordance with our hypothesis, ultrathin coatings of gold provoked a neointimal response and degree of luminal occlusion greater than that of plain platinum aneurysm coils in a rat arterial occlusion model. Home Subscribe Author Instructions Submit Online Search the AJNR Archives Feedback Help Copyright © 2010 by the American Society of Neuroradiology. Print ISSN: 0195-6108 Online ISSN: 1936-959X http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png American Journal of Neuroradiology American Journal of Neuroradiology

Endovascular Histologic Effects of Ultrathin Gold- or Vitronectin-Coated Platinum Aneurysm Coils in a Rodent Arterial Occlusion Model: A Preliminary Investigation

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Publisher
American Journal of Neuroradiology
Copyright
Copyright © 2010 by the American Society of Neuroradiology.
ISSN
0195-6108
eISSN
1936-959X
DOI
10.3174/ajnr.A1368
Publisher site
See Article on Publisher Site

Abstract

This Article Figures Only Full Text Full Text (PDF) All Versions of this Article: ajnr.A1368v1 30/1/85 most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Whitlow, C.T. Articles by Morris, P.P. Search for Related Content PubMed PubMed Citation Articles by Whitlow, C.T. Articles by Morris, P.P. Hotlight (NEW!) What's Hotlight? American Journal of Neuroradiology 30:85-90, January 2009 © 2009 American Society of Neuroradiology INTERVENTIONAL Endovascular Histologic Effects of Ultrathin Gold- or Vitronectin-Coated Platinum Aneurysm Coils in a Rodent Arterial Occlusion Model: A Preliminary Investigation C.T. Whitlow a , C.P. Geer a , C.W.T. Mattern a , B.J. Mussat-Whitlow d , S.K. Yazdani b , J.L. Berry b , J.H. Lalli e , R.O. Claus e , V.R. Challa c and P.P. Morris a a Departments of Radiology, Wake Forest University School of Medicine, Winston-Salem, NC b Departments of Biomedical Engineering, Wake Forest University School of Medicine, Winston-Salem, NC c Departments of Pathology, Wake Forest University School of Medicine, Winston-Salem, NC d Division of Institutional Planning, Assessment, and Research, Winston-Salem State University, Winston-Salem, NC e NanoSonic Inc, Blacksburg, Va Please address correspondence to P. Pearse Morris, MD, Division of Radiologic Sciences, Department of Radiology, Wake Forest University School of Medicine, Medical Center Blvd, Winston-Salem, NC; e-mail: pmorris@wfubmc.edu BACKGROUND AND PURPOSE: Novel stratagems to improve the efficacy of platinum coils in occluding cerebral aneurysms have primarily involved coating coils with materials thought likely to provoke more desirable histologic reactions. No investigations to date, however, have evaluated the utility of gold or vitronectin coatings, despite known endovascular histologic effects of these agents, which may be favorable for treating cerebral aneurysms. This study was conducted to evaluate the degree of endovascular histologic change associated with ultrathin gold- or vitronectin-coated platinum coils. It was hypothesized that such coatings would increase intra-aneurysmal intimal hyperplasia and the degree of luminal occlusion compared with standard platinum coils. MATERIALS AND METHODS: The ligated carotid artery rat model was used to study 4 different aneurysm coil conditions: no coil (sham-surgery controls), uncoated platinum coil, and gold- or vitronectin-coated platinum coil. Two weeks postimplantation, the aneurysms were harvested and stained with hematoxylin-eosin. Slides were evaluated for the degree of neointimal response by a pathologist blinded to treatment. Additional quantitative evaluation was performed blindly by using the ratio of intimal-to-luminal cross-sectional area. RESULTS: A gold- or vitronectin-coated platinum aneurysm coil produced a statistically significant increase in neointimal response compared with a sham (no coil). Arterial segments treated with gold-coated platinum coils also demonstrated a statistically significant 100% increase in neointimal response compared with those treated with bare platinum coils. CONCLUSIONS: In concordance with our hypothesis, ultrathin coatings of gold provoked a neointimal response and degree of luminal occlusion greater than that of plain platinum aneurysm coils in a rat arterial occlusion model. Home Subscribe Author Instructions Submit Online Search the AJNR Archives Feedback Help Copyright © 2010 by the American Society of Neuroradiology. Print ISSN: 0195-6108 Online ISSN: 1936-959X

Journal

American Journal of NeuroradiologyAmerican Journal of Neuroradiology

Published: Jan 1, 2009

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