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Do Prior Iodine Contrast Injections Affect Cerebral Blood Flow Measurement on CT Perfusion Studies of Patients with Large-Vessel Occlusions?

Do Prior Iodine Contrast Injections Affect Cerebral Blood Flow Measurement on CT Perfusion... LETTERS Do Prior Iodine Contrast Injections Affect Cerebral Blood Flow Measurement on CT Perfusion Studies of Patients with Large-Vessel Occlusions? e read with great interest the recent study by Copelan et al each with a separate bolus injection, to achieve the desired 80- Win which the authors concluded that recent administration mm coverage. This means that the second CTP slab is, by defini- (, 8 hours) of iodinated contrast renders infarct estimations inac- tion, a postcontrast scan in both patient groups. Thus, any con- curate using a commercial CTP processing software. We believe founding effects from prior iodine administration should be that the conclusions suffer from unassessed confounders and mis- observed in the second CTP slab in both groups. However, when interpretations deserving of clarification for the prospective reader. allowing at least 90 seconds between the 2 CTP acquisitions, we First, the small cohort (n¼ 38) differs not only in the use of have not encountered such issues in our experience with either iodine, but also in presentation time and infarct size. The transfer dual slab protocols or cases in which the CTA is acquired before patient group arrived approximately 3.2 hours later than the the CTP. If leakage http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png American Journal of Neuroradiology American Journal of Neuroradiology

Do Prior Iodine Contrast Injections Affect Cerebral Blood Flow Measurement on CT Perfusion Studies of Patients with Large-Vessel Occlusions?

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Publisher
American Journal of Neuroradiology
Copyright
© 2021 by American Journal of Neuroradiology
ISSN
0195-6108
eISSN
1936-959X
DOI
10.3174/ajnr.A7139
Publisher site
See Article on Publisher Site

Abstract

LETTERS Do Prior Iodine Contrast Injections Affect Cerebral Blood Flow Measurement on CT Perfusion Studies of Patients with Large-Vessel Occlusions? e read with great interest the recent study by Copelan et al each with a separate bolus injection, to achieve the desired 80- Win which the authors concluded that recent administration mm coverage. This means that the second CTP slab is, by defini- (, 8 hours) of iodinated contrast renders infarct estimations inac- tion, a postcontrast scan in both patient groups. Thus, any con- curate using a commercial CTP processing software. We believe founding effects from prior iodine administration should be that the conclusions suffer from unassessed confounders and mis- observed in the second CTP slab in both groups. However, when interpretations deserving of clarification for the prospective reader. allowing at least 90 seconds between the 2 CTP acquisitions, we First, the small cohort (n¼ 38) differs not only in the use of have not encountered such issues in our experience with either iodine, but also in presentation time and infarct size. The transfer dual slab protocols or cases in which the CTA is acquired before patient group arrived approximately 3.2 hours later than the the CTP. If leakage

Journal

American Journal of Neuroradiology – American Journal of Neuroradiology

Published: Aug 1, 2021

References

  • Recent administration of iodinated contrast renders core infarct estimation inaccurate using RAPID software
    AZ. Copelan, ER. Smith, GT. Drocton
  • Accuracy and reliability assessment of CT and MR perfusion analysis software using a digital phantom
    K. Kudo, S. Christensen, M. Sasaki
  • Outcomes of endovascular thrombectomy vs medical management alone in patients with large ischemic cores: a secondary analysis of the optimizing patient's selection for endovascular treatment in acute ischemic stroke (SELECT) study
    A. Sarraj, AE. Hassan, S. Savitz
  • Performance and predictive value of a user-independent platform for CT perfusion analysis: threshold-derived automated systems outperform examiner-driven approaches in outcome prediction of acute ischemic stroke
    S. Dehkharghani, R. Bammer, M. Straka