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Diffusion-Weighted Imaging in the Follow-up of Treated High-Grade Gliomas: Tumor Recurrence versus Radiation Injury

Diffusion-Weighted Imaging in the Follow-up of Treated High-Grade Gliomas: Tumor Recurrence... This Article Figures Only Full Text Full Text (PDF) Supplemental Tables Alert me when this article is cited Alert me if a correction is posted Citation Map Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Hein, P. A. Articles by Hug, E. B. Search for Related Content PubMed PubMed Citation Articles by Hein, P. A. Articles by Hug, E. B. Hotlight (NEW!) What's Hotlight? American Journal of Neuroradiology 25:201-209, February 2004 © 2004 American Society of Neuroradiology BRAIN Diffusion-Weighted Imaging in the Follow-up of Treated High-Grade Gliomas: Tumor Recurrence versus Radiation Injury Patrick A. Hein a , Clifford J. Eskey b , Jeffrey F. Dunn b and Eugen B. Hug a a Section of Radiation Oncology, Norris Cotton Cancer Center, Lebanon, NH b Department of Radiology, Dartmouth-Hitchcock Medical Center, Lebanon, NH Address reprint requests to Patrick A. Hein, MD, Department of Radiology, Charité, Humboldt Universitaet zu Berlin, Schumannstr. 20/21, 10098 Berlin, Germany BACKGROUND AND PURPOSE: Diffusion-weighted (DW) MR imaging is a means to characterize and differentiate morphologic features, including edema, necrosis, and tumor tissue, by measuring differences in apparent diffusion coefficient (ADC). We hypothesized that DW imaging has the potential to differentiate recurrent or progressive tumor growth from treatment-induced damage to brain parenchyma in high-grade gliomas after radiation therapy. METHODS: We retrospectively reviewed follow-up conventional and DW MR images obtained starting 1 month after completion of radiation treatment with or without chemotherapy for histologically proved high-grade gliomas. Eighteen patients with areas of abnormal enhancing tissue were identified. ADC maps were calculated from echo-planar DW images, and mean ADC values and ADC ratios (ADC of enhancing lesion to ADC of contralateral white matter) were compared with final diagnosis. Recurrence was established by histologic examination or by clinical course and a combination of imaging studies. RESULTS: Recurrence and nonrecurrence could be differentiated by using mean ADC values and ADC ratios. ADC ratios in the recurrence group showed significantly lower values (mean ± SD, 1.43 ± 0.11) than those of the nonrecurrence group (1.82 ± 0.07, P < .001). Mean ADCs of the recurrent tumors (mean ± SD, 1.18 ± 0.13 x 10 -3 mm/s 2 ) were significantly lower than those of the nonrecurrence group (1.40 ± 0.17 x 10 -3 mm/s 2 , P < .006). CONCLUSION: Assessment of ADC ratios of enhancing regions in the follow-up of treated high-grade gliomas is useful in differentiating radiation effects from tumor recurrence or progression. This article has been cited by other articles: A. Al Sayyari, R. Buckley, C. McHenery, K. Pannek, A. Coulthard, and S. Rose Distinguishing Recurrent Primary Brain Tumor from Radiation Injury: A Preliminary Study Using a Susceptibility-Weighted MR Imaging-Guided Apparent Diffusion Coefficient Analysis Strategy AJNR Am. J. Neuroradiol., June 1, 2010; 31(6): 1049 - 1054. Abstract Full Text PDF A. I. Holodny, S. Makeyev, B. J. Beattie, S. Riad, and R. G. Blasberg Apparent Diffusion Coefficient of Glial Neoplasms: Correlation with Fluorodeoxyglucose-Positron-Emission Tomography and Gadolinium-Enhanced MR Imaging AJNR Am. J. Neuroradiol., June 1, 2010; 31(6): 1042 - 1048. Abstract Full Text PDF P.C. Sundgren MR Spectroscopy in Radiation Injury AJNR Am. J. Neuroradiol., September 1, 2009; 30(8): 1469 - 1476. Abstract Full Text PDF V. Vandecaveye, F. De Keyzer, V. Vander Poorten, P. Dirix, E. Verbeken, S. Nuyts, and R. Hermans Head and Neck Squamous Cell Carcinoma: Value of Diffusion-weighted MR Imaging for Nodal Staging1 Radiology, April 1, 2009; 251(1): 134 - 146. Abstract Full Text PDF J.A. Castelijns and C. R. Leemans Closing the Uncertainty Gap in the Diagnosis of Parotid Tumors AJNR Am. J. Neuroradiol., March 1, 2009; 30(3): 442 - 443. Full Text PDF E. L. Gasparetto, M. A. Pawlak, S. H. Patel, J. Huse, J. H. Woo, J. Krejza, M. R. Rosenfeld, D. M. O'Rourke, R. Lustig, E. R. Melhem, et al. Posttreatment Recurrence of Malignant Brain Neoplasm: Accuracy of Relative Cerebral Blood Volume Fraction in Discriminating Low from High Malignant Histologic Volume Fraction Radiology, March 1, 2009; 250(3): 887 - 896. Abstract Full Text PDF R.F. Barajas, J.S. Chang, P.K. Sneed, M.R. Segal, M.W. McDermott, and S. Cha Distinguishing Recurrent Intra-Axial Metastatic Tumor from Radiation Necrosis Following Gamma Knife Radiosurgery Using Dynamic Susceptibility-Weighted Contrast-Enhanced Perfusion MR Imaging AJNR Am. J. Neuroradiol., February 1, 2009; 30(2): 367 - 372. Abstract Full Text PDF M. E. P. Philippens, G. Gambarota, A. J. van der Kogel, and A. Heerschap Radiation Effects in the Rat Spinal Cord: Evaluation with Apparent Diffusion Coefficient versus T2 at Serial MR Imaging Radiology, February 1, 2009; 250(2): 387 - 397. Abstract Full Text PDF V.A. Nagar, J.R. Ye, W.H. Ng, Y.H. Chan, F. Hui, C.K. Lee, and C.C.T. Lim Diffusion-Weighted MR Imaging: Diagnosing Atypical or Malignant Meningiomas and Detecting Tumor Dedifferentiation AJNR Am. J. Neuroradiol., June 1, 2008; 29(6): 1147 - 1152. Abstract Full Text PDF H.S. Seo, K.-H. Chang, D.G. Na, B.J. Kwon, and D.H. Lee High b-Value Diffusion (b = 3000 s/mm2) MR Imaging in Cerebral Gliomas at 3T: Visual and Quantitative Comparisons with b = 1000 s/mm2 AJNR Am. J. Neuroradiol., March 1, 2008; 29(3): 458 - 463. Abstract Full Text PDF T. Welzel, A. Niethammer, U. Mende, S. Heiland, F. Wenz, J. Debus, and R. Krempien Diffusion Tensor Imaging Screening of Radiation-Induced Changes in the White Matter after Prophylactic Cranial Irradiation of Patients with Small Cell Lung Cancer: First Results of a Prospective Study AJNR Am. J. Neuroradiol., February 1, 2008; 29(2): 379 - 383. Abstract Full Text PDF D. A. Torigian, S. S. Huang, M. Houseni, and A. Alavi Functional Imaging of Cancer with Emphasis on Molecular Techniques CA Cancer J Clin, July 1, 2007; 57(4): 206 - 224. Abstract Full Text PDF A.A.K. A. Razek, A.Y. Kandeel, N. Soliman, H.M. El-shenshawy, Y. Kamel, N. Nada, and A. Denewar Role of Diffusion-Weighted Echo-Planar MR Imaging in Differentiation of Residual or Recurrent Head and Neck Tumors and Posttreatment Changes AJNR Am. J. Neuroradiol., June 1, 2007; 28(6): 1146 - 1152. Abstract Full Text PDF D.-M. Koh, E. Scurr, D. Collins, B. Kanber, A. Norman, M. O. Leach, and J. E. Husband Predicting Response of Colorectal Hepatic Metastasis: Value of Pretreatment Apparent Diffusion Coefficients Am. J. Roentgenol., April 1, 2007; 188(4): 1001 - 1008. Abstract Full Text PDF V Vandecaveye, F de Keyzer, V Vander Poorten, K Deraedt, H Alaerts, W Landuyt, S Nuyts, and R Hermans Evaluation of the larynx for tumour recurrence by diffusion-weighted MRI after radiotherapy: initial experience in four cases Br. J. Radiol., August 1, 2006; 79(944): 681 - 687. Abstract Full Text PDF G G Fan, Q L Deng, Z H Wu, and Q Y Guo Usefulness of diffusion/perfusion-weighted MRI in patients with non-enhancing supratentorial brain gliomas: a valuable tool to predict tumour grading? Br. J. Radiol., August 1, 2006; 79(944): 652 - 658. Abstract Full Text PDF Z. Rumboldt, D.L.A. Camacho, D. Lake, C.T. Welsh, and M. Castillo Apparent Diffusion Coefficients for Differentiation of Cerebellar Tumors in Children AJNR Am. J. Neuroradiol., June 1, 2006; 27(6): 1362 - 1369. Abstract Full Text PDF J. M. Provenzale, S. Mukundan, and D. P. Barboriak Diffusion-weighted and Perfusion MR Imaging for Brain Tumor Characterization and Assessment of Treatment Response. Radiology, June 1, 2006; 239(3): 632 - 649. Abstract Full Text PDF N. A. Butowski, P. K. Sneed, and S. M. Chang Diagnosis and Treatment of Recurrent High-Grade Astrocytoma J. Clin. Oncol., March 10, 2006; 24(8): 1273 - 1280. Abstract Full Text PDF P. Weybright, P. C. Sundgren, P. Maly, D. G. Hassan, B. Nan, S. Rohrer, and L. Junck Differentiation Between Brain Tumor Recurrence and Radiation Injury Using MR Spectroscopy Am. J. Roentgenol., December 1, 2005; 185(6): 1471 - 1476. Abstract Full Text PDF M. E. Mullins, G. D. Barest, P. W. Schaefer, F. H. Hochberg, R. G. Gonzalez, and M. H. Lev Radiation Necrosis Versus Glioma Recurrence: Conventional MR Imaging Clues to Diagnosis AJNR Am. J. Neuroradiol., September 1, 2005; 26(8): 1967 - 1972. Abstract Full Text PDF C. Asao, Y. Korogi, M. Kitajima, T. Hirai, Y. Baba, K. Makino, M. Kochi, S. Morishita, and Y. Yamashita Diffusion-Weighted Imaging of Radiation-Induced Brain Injury for Differentiation from Tumor Recurrence AJNR Am. J. Neuroradiol., June 1, 2005; 26(6): 1455 - 1460. Abstract Full Text PDF W.-Y. Guo Is Current Imaging Good Enough to Differentiate Radiation-Induced Brain Injury from Tumor Recurrence? AJNR Am. J. Neuroradiol., June 1, 2005; 26(6): 1305 - 1305. Full Text PDF Home Subscribe Author Instructions Submit Online Search the AJNR Archives Feedback Help Copyright © 2010 by the American Society of Neuroradiology. Print ISSN: 0195-6108 Online ISSN: 1936-959X http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png American Journal of Neuroradiology American Journal of Neuroradiology

Diffusion-Weighted Imaging in the Follow-up of Treated High-Grade Gliomas: Tumor Recurrence versus Radiation Injury

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American Journal of Neuroradiology
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Copyright © 2010 by the American Society of Neuroradiology.
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0195-6108
eISSN
1936-959X
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Abstract

This Article Figures Only Full Text Full Text (PDF) Supplemental Tables Alert me when this article is cited Alert me if a correction is posted Citation Map Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Hein, P. A. Articles by Hug, E. B. Search for Related Content PubMed PubMed Citation Articles by Hein, P. A. Articles by Hug, E. B. Hotlight (NEW!) What's Hotlight? American Journal of Neuroradiology 25:201-209, February 2004 © 2004 American Society of Neuroradiology BRAIN Diffusion-Weighted Imaging in the Follow-up of Treated High-Grade Gliomas: Tumor Recurrence versus Radiation Injury Patrick A. Hein a , Clifford J. Eskey b , Jeffrey F. Dunn b and Eugen B. Hug a a Section of Radiation Oncology, Norris Cotton Cancer Center, Lebanon, NH b Department of Radiology, Dartmouth-Hitchcock Medical Center, Lebanon, NH Address reprint requests to Patrick A. Hein, MD, Department of Radiology, Charité, Humboldt Universitaet zu Berlin, Schumannstr. 20/21, 10098 Berlin, Germany BACKGROUND AND PURPOSE: Diffusion-weighted (DW) MR imaging is a means to characterize and differentiate morphologic features, including edema, necrosis, and tumor tissue, by measuring differences in apparent diffusion coefficient (ADC). We hypothesized that DW imaging has the potential to differentiate recurrent or progressive tumor growth from treatment-induced damage to brain parenchyma in high-grade gliomas after radiation therapy. METHODS: We retrospectively reviewed follow-up conventional and DW MR images obtained starting 1 month after completion of radiation treatment with or without chemotherapy for histologically proved high-grade gliomas. Eighteen patients with areas of abnormal enhancing tissue were identified. ADC maps were calculated from echo-planar DW images, and mean ADC values and ADC ratios (ADC of enhancing lesion to ADC of contralateral white matter) were compared with final diagnosis. Recurrence was established by histologic examination or by clinical course and a combination of imaging studies. RESULTS: Recurrence and nonrecurrence could be differentiated by using mean ADC values and ADC ratios. ADC ratios in the recurrence group showed significantly lower values (mean ± SD, 1.43 ± 0.11) than those of the nonrecurrence group (1.82 ± 0.07, P < .001). Mean ADCs of the recurrent tumors (mean ± SD, 1.18 ± 0.13 x 10 -3 mm/s 2 ) were significantly lower than those of the nonrecurrence group (1.40 ± 0.17 x 10 -3 mm/s 2 , P < .006). CONCLUSION: Assessment of ADC ratios of enhancing regions in the follow-up of treated high-grade gliomas is useful in differentiating radiation effects from tumor recurrence or progression. This article has been cited by other articles: A. Al Sayyari, R. Buckley, C. McHenery, K. Pannek, A. Coulthard, and S. Rose Distinguishing Recurrent Primary Brain Tumor from Radiation Injury: A Preliminary Study Using a Susceptibility-Weighted MR Imaging-Guided Apparent Diffusion Coefficient Analysis Strategy AJNR Am. J. Neuroradiol., June 1, 2010; 31(6): 1049 - 1054. Abstract Full Text PDF A. I. Holodny, S. Makeyev, B. J. Beattie, S. Riad, and R. G. Blasberg Apparent Diffusion Coefficient of Glial Neoplasms: Correlation with Fluorodeoxyglucose-Positron-Emission Tomography and Gadolinium-Enhanced MR Imaging AJNR Am. J. Neuroradiol., June 1, 2010; 31(6): 1042 - 1048. Abstract Full Text PDF P.C. Sundgren MR Spectroscopy in Radiation Injury AJNR Am. J. Neuroradiol., September 1, 2009; 30(8): 1469 - 1476. Abstract Full Text PDF V. Vandecaveye, F. De Keyzer, V. Vander Poorten, P. Dirix, E. Verbeken, S. Nuyts, and R. Hermans Head and Neck Squamous Cell Carcinoma: Value of Diffusion-weighted MR Imaging for Nodal Staging1 Radiology, April 1, 2009; 251(1): 134 - 146. Abstract Full Text PDF J.A. Castelijns and C. R. Leemans Closing the Uncertainty Gap in the Diagnosis of Parotid Tumors AJNR Am. J. Neuroradiol., March 1, 2009; 30(3): 442 - 443. Full Text PDF E. L. Gasparetto, M. A. Pawlak, S. H. Patel, J. Huse, J. H. Woo, J. Krejza, M. R. Rosenfeld, D. M. O'Rourke, R. Lustig, E. R. Melhem, et al. Posttreatment Recurrence of Malignant Brain Neoplasm: Accuracy of Relative Cerebral Blood Volume Fraction in Discriminating Low from High Malignant Histologic Volume Fraction Radiology, March 1, 2009; 250(3): 887 - 896. Abstract Full Text PDF R.F. Barajas, J.S. Chang, P.K. Sneed, M.R. Segal, M.W. McDermott, and S. Cha Distinguishing Recurrent Intra-Axial Metastatic Tumor from Radiation Necrosis Following Gamma Knife Radiosurgery Using Dynamic Susceptibility-Weighted Contrast-Enhanced Perfusion MR Imaging AJNR Am. J. Neuroradiol., February 1, 2009; 30(2): 367 - 372. Abstract Full Text PDF M. E. P. Philippens, G. Gambarota, A. J. van der Kogel, and A. Heerschap Radiation Effects in the Rat Spinal Cord: Evaluation with Apparent Diffusion Coefficient versus T2 at Serial MR Imaging Radiology, February 1, 2009; 250(2): 387 - 397. Abstract Full Text PDF V.A. Nagar, J.R. Ye, W.H. Ng, Y.H. Chan, F. Hui, C.K. Lee, and C.C.T. Lim Diffusion-Weighted MR Imaging: Diagnosing Atypical or Malignant Meningiomas and Detecting Tumor Dedifferentiation AJNR Am. J. Neuroradiol., June 1, 2008; 29(6): 1147 - 1152. Abstract Full Text PDF H.S. Seo, K.-H. Chang, D.G. Na, B.J. Kwon, and D.H. Lee High b-Value Diffusion (b = 3000 s/mm2) MR Imaging in Cerebral Gliomas at 3T: Visual and Quantitative Comparisons with b = 1000 s/mm2 AJNR Am. J. Neuroradiol., March 1, 2008; 29(3): 458 - 463. Abstract Full Text PDF T. Welzel, A. Niethammer, U. Mende, S. Heiland, F. Wenz, J. Debus, and R. Krempien Diffusion Tensor Imaging Screening of Radiation-Induced Changes in the White Matter after Prophylactic Cranial Irradiation of Patients with Small Cell Lung Cancer: First Results of a Prospective Study AJNR Am. J. Neuroradiol., February 1, 2008; 29(2): 379 - 383. Abstract Full Text PDF D. A. Torigian, S. S. Huang, M. Houseni, and A. Alavi Functional Imaging of Cancer with Emphasis on Molecular Techniques CA Cancer J Clin, July 1, 2007; 57(4): 206 - 224. Abstract Full Text PDF A.A.K. A. Razek, A.Y. Kandeel, N. Soliman, H.M. El-shenshawy, Y. Kamel, N. Nada, and A. Denewar Role of Diffusion-Weighted Echo-Planar MR Imaging in Differentiation of Residual or Recurrent Head and Neck Tumors and Posttreatment Changes AJNR Am. J. Neuroradiol., June 1, 2007; 28(6): 1146 - 1152. Abstract Full Text PDF D.-M. Koh, E. Scurr, D. Collins, B. Kanber, A. Norman, M. O. Leach, and J. E. Husband Predicting Response of Colorectal Hepatic Metastasis: Value of Pretreatment Apparent Diffusion Coefficients Am. J. Roentgenol., April 1, 2007; 188(4): 1001 - 1008. Abstract Full Text PDF V Vandecaveye, F de Keyzer, V Vander Poorten, K Deraedt, H Alaerts, W Landuyt, S Nuyts, and R Hermans Evaluation of the larynx for tumour recurrence by diffusion-weighted MRI after radiotherapy: initial experience in four cases Br. J. Radiol., August 1, 2006; 79(944): 681 - 687. Abstract Full Text PDF G G Fan, Q L Deng, Z H Wu, and Q Y Guo Usefulness of diffusion/perfusion-weighted MRI in patients with non-enhancing supratentorial brain gliomas: a valuable tool to predict tumour grading? Br. J. Radiol., August 1, 2006; 79(944): 652 - 658. Abstract Full Text PDF Z. Rumboldt, D.L.A. Camacho, D. Lake, C.T. Welsh, and M. Castillo Apparent Diffusion Coefficients for Differentiation of Cerebellar Tumors in Children AJNR Am. J. Neuroradiol., June 1, 2006; 27(6): 1362 - 1369. Abstract Full Text PDF J. M. Provenzale, S. Mukundan, and D. P. Barboriak Diffusion-weighted and Perfusion MR Imaging for Brain Tumor Characterization and Assessment of Treatment Response. Radiology, June 1, 2006; 239(3): 632 - 649. Abstract Full Text PDF N. A. Butowski, P. K. Sneed, and S. M. Chang Diagnosis and Treatment of Recurrent High-Grade Astrocytoma J. Clin. Oncol., March 10, 2006; 24(8): 1273 - 1280. Abstract Full Text PDF P. Weybright, P. C. Sundgren, P. Maly, D. G. Hassan, B. Nan, S. Rohrer, and L. Junck Differentiation Between Brain Tumor Recurrence and Radiation Injury Using MR Spectroscopy Am. J. Roentgenol., December 1, 2005; 185(6): 1471 - 1476. Abstract Full Text PDF M. E. Mullins, G. D. Barest, P. W. Schaefer, F. H. Hochberg, R. G. Gonzalez, and M. H. Lev Radiation Necrosis Versus Glioma Recurrence: Conventional MR Imaging Clues to Diagnosis AJNR Am. J. Neuroradiol., September 1, 2005; 26(8): 1967 - 1972. Abstract Full Text PDF C. Asao, Y. Korogi, M. Kitajima, T. Hirai, Y. Baba, K. Makino, M. Kochi, S. Morishita, and Y. Yamashita Diffusion-Weighted Imaging of Radiation-Induced Brain Injury for Differentiation from Tumor Recurrence AJNR Am. J. Neuroradiol., June 1, 2005; 26(6): 1455 - 1460. Abstract Full Text PDF W.-Y. Guo Is Current Imaging Good Enough to Differentiate Radiation-Induced Brain Injury from Tumor Recurrence? AJNR Am. J. Neuroradiol., June 1, 2005; 26(6): 1305 - 1305. Full Text PDF Home Subscribe Author Instructions Submit Online Search the AJNR Archives Feedback Help Copyright © 2010 by the American Society of Neuroradiology. Print ISSN: 0195-6108 Online ISSN: 1936-959X

Journal

American Journal of Neuroradiology – American Journal of Neuroradiology

Published: Feb 1, 2004

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