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Differentiation of Brain Abscesses from Necrotic Glioblastomas and Cystic Metastatic Brain Tumors with Diffusion Tensor Imaging

Differentiation of Brain Abscesses from Necrotic Glioblastomas and Cystic Metastatic Brain Tumors... BACKGROUND AND PURPOSE: The differentiation of abscesses from glioblastomas and metastases may not always be possible on the basis of DWI. Our hypothesis was that differences in diffusion properties as detected by DTI allow differentiation of abscess from glioblastomas and metastasis. Furthermore, diagnostic performance of tensor metrics quantifying anisotropy or tensor shapes is better than that of ADC in measuring mean diffusivity for this purpose. MATERIALS AND METHODS: DTI was performed in 15 abscesses, 15 necrotic glioblastomas, and 26 cystic metastases. In each lesion, manually segmented into 4 regions of interest (ie, cystic cavity, enhancing rim, and immediate (edema most adjacent to the enhancing rim) and distant zones of edema), FA, ADC, C l , C p , and C s values were measured and statistically compared among groups and evaluated with ROC curve analysis. The presence of a hyperintense FA rim (a rim of edematous tissue that was hyperintense on the FA map) was assessed visually. RESULTS: Abscess was significantly different from glioblastoma for all tensor metrics measured in the cystic cavity and immediate zone of edema and for all except C l in the enhancing rim. Abscess was significantly different from metastasis for all tensor metrics measured in the cystic cavity and enhancing rim and for FA, ADC, and C l in immediate zone of edema. The incidence of a hyperintense FA rim was significantly higher in glioblastoma and metastasis compared with abscess. The 3 tensor metrics with the highest performance in differentiating abscess from glioblastoma and metastasis were FA, C l , and C s of the cystic cavity. CONCLUSIONS: DTI is able to differentiate abscess from glioblastoma and metastasis. FA, C l , and C s outperformed ADC in diagnostic performance comparisons. Abbreviations ADC apparent diffusion coefficient AUC area under the curve CC cystic cavity C l linear tensor C p planar tensor C s spheric tensor DTI diffusion tensor imaging DWI diffusion-weighted imaging DZE distant zone of edema ER enhancing rim FA fractional anisotropy GB glioblastoma IZE immediate zone of edema Mets metastasis MPRAGE magnetization-prepared rapid acquisition of gradient echo NAWM normal-appearing white matter ROC receiver operating characteristic http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png American Journal of Neuroradiology American Journal of Neuroradiology

Differentiation of Brain Abscesses from Necrotic Glioblastomas and Cystic Metastatic Brain Tumors with Diffusion Tensor Imaging

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References (24)

Publisher
American Journal of Neuroradiology
Copyright
Copyright © 2011 by the American Society of Neuroradiology.
ISSN
0195-6108
eISSN
1936-959X
DOI
10.3174/ajnr.A2581
pmid
21835939
Publisher site
See Article on Publisher Site

Abstract

BACKGROUND AND PURPOSE: The differentiation of abscesses from glioblastomas and metastases may not always be possible on the basis of DWI. Our hypothesis was that differences in diffusion properties as detected by DTI allow differentiation of abscess from glioblastomas and metastasis. Furthermore, diagnostic performance of tensor metrics quantifying anisotropy or tensor shapes is better than that of ADC in measuring mean diffusivity for this purpose. MATERIALS AND METHODS: DTI was performed in 15 abscesses, 15 necrotic glioblastomas, and 26 cystic metastases. In each lesion, manually segmented into 4 regions of interest (ie, cystic cavity, enhancing rim, and immediate (edema most adjacent to the enhancing rim) and distant zones of edema), FA, ADC, C l , C p , and C s values were measured and statistically compared among groups and evaluated with ROC curve analysis. The presence of a hyperintense FA rim (a rim of edematous tissue that was hyperintense on the FA map) was assessed visually. RESULTS: Abscess was significantly different from glioblastoma for all tensor metrics measured in the cystic cavity and immediate zone of edema and for all except C l in the enhancing rim. Abscess was significantly different from metastasis for all tensor metrics measured in the cystic cavity and enhancing rim and for FA, ADC, and C l in immediate zone of edema. The incidence of a hyperintense FA rim was significantly higher in glioblastoma and metastasis compared with abscess. The 3 tensor metrics with the highest performance in differentiating abscess from glioblastoma and metastasis were FA, C l , and C s of the cystic cavity. CONCLUSIONS: DTI is able to differentiate abscess from glioblastoma and metastasis. FA, C l , and C s outperformed ADC in diagnostic performance comparisons. Abbreviations ADC apparent diffusion coefficient AUC area under the curve CC cystic cavity C l linear tensor C p planar tensor C s spheric tensor DTI diffusion tensor imaging DWI diffusion-weighted imaging DZE distant zone of edema ER enhancing rim FA fractional anisotropy GB glioblastoma IZE immediate zone of edema Mets metastasis MPRAGE magnetization-prepared rapid acquisition of gradient echo NAWM normal-appearing white matter ROC receiver operating characteristic

Journal

American Journal of NeuroradiologyAmerican Journal of Neuroradiology

Published: Oct 1, 2011

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