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Differences in Hemodynamics and Rupture Rate of Aneurysms at the Bifurcation of the Basilar and Internal Carotid Arteries

Differences in Hemodynamics and Rupture Rate of Aneurysms at the Bifurcation of the Basilar and... BACKGROUND AND PURPOSE: Cerebral aneurysms in the posterior circulation are known to have a higher rupture risk than those in the anterior circulation. We sought to test the hypothesis that differences in hemodynamics can explain the difference in rupture rates. MATERIALS AND METHODS: A total of 117 aneurysms, 63 at the tip of the basilar artery (27 ruptured, 36 unruptured, rupture rate = 43%) and 54 at the bifurcation of the internal carotid artery (11 ruptured, 43 unruptured, rupture rate = 20%) were analyzed with image-based computational fluid dynamics. Several hemodynamic variables were compared among aneurysms at each location and between ruptured and unruptured aneurysms at each location. RESULTS: On average, aneurysms at the basilar tip had more concentrated inflow ( P < .001), a larger inflow rate ( P < .001), a larger maximum oscillatory shear index ( P = .003), more complex flows ( P = .033), and smaller areas under low wall shear stress ( P < .001) than aneurysms at the bifurcation of the internal carotid artery. In general, ruptured aneurysms had larger inflow concentration ( P = .02), larger shear concentration ( P = .02), more complex flows ( P < .001), and smaller minimum wall shear stress ( P = .003) than unruptured aneurysms. CONCLUSIONS: High flow conditions, characterized by large and concentrated inflow jets, complex and oscillatory flow patterns, and wall shear stress distributions with focalized regions of high shear and large regions of low shear, are associated with aneurysm rupture, especially for basilar tip aneurysms. The higher flow conditions in basilar tip aneurysms could explain their increased rupture risk compared with internal carotid bifurcation aneurysms. ABBREVIATIONS: BAtip basilar artery tip corelen core-line length ICAbif internal carotid artery bifurcation ICI inflow concentration index LSA areas under low wall shear stress max maximum min minimum OSI oscillatory shear index Q flow rate SCI shear concentration index VE mean velocity WSS wall shear stress http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png American Journal of Neuroradiology American Journal of Neuroradiology

Differences in Hemodynamics and Rupture Rate of Aneurysms at the Bifurcation of the Basilar and Internal Carotid Arteries

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Publisher
American Journal of Neuroradiology
Copyright
Copyright © 2017 by the American Society of Neuroradiology.
ISSN
0195-6108
eISSN
1936-959X
DOI
10.3174/ajnr.A5088
pmid
28209576
Publisher site
See Article on Publisher Site

Abstract

BACKGROUND AND PURPOSE: Cerebral aneurysms in the posterior circulation are known to have a higher rupture risk than those in the anterior circulation. We sought to test the hypothesis that differences in hemodynamics can explain the difference in rupture rates. MATERIALS AND METHODS: A total of 117 aneurysms, 63 at the tip of the basilar artery (27 ruptured, 36 unruptured, rupture rate = 43%) and 54 at the bifurcation of the internal carotid artery (11 ruptured, 43 unruptured, rupture rate = 20%) were analyzed with image-based computational fluid dynamics. Several hemodynamic variables were compared among aneurysms at each location and between ruptured and unruptured aneurysms at each location. RESULTS: On average, aneurysms at the basilar tip had more concentrated inflow ( P < .001), a larger inflow rate ( P < .001), a larger maximum oscillatory shear index ( P = .003), more complex flows ( P = .033), and smaller areas under low wall shear stress ( P < .001) than aneurysms at the bifurcation of the internal carotid artery. In general, ruptured aneurysms had larger inflow concentration ( P = .02), larger shear concentration ( P = .02), more complex flows ( P < .001), and smaller minimum wall shear stress ( P = .003) than unruptured aneurysms. CONCLUSIONS: High flow conditions, characterized by large and concentrated inflow jets, complex and oscillatory flow patterns, and wall shear stress distributions with focalized regions of high shear and large regions of low shear, are associated with aneurysm rupture, especially for basilar tip aneurysms. The higher flow conditions in basilar tip aneurysms could explain their increased rupture risk compared with internal carotid bifurcation aneurysms. ABBREVIATIONS: BAtip basilar artery tip corelen core-line length ICAbif internal carotid artery bifurcation ICI inflow concentration index LSA areas under low wall shear stress max maximum min minimum OSI oscillatory shear index Q flow rate SCI shear concentration index VE mean velocity WSS wall shear stress

Journal

American Journal of NeuroradiologyAmerican Journal of Neuroradiology

Published: Mar 1, 2017

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