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Current and Emerging Therapies in Multiple Sclerosis: Implications for the Radiologist, Part 1—Mechanisms, Efficacy, and Safety

Current and Emerging Therapies in Multiple Sclerosis: Implications for the Radiologist, Part... REVIEWARTICLE CurrentandEmergingTherapiesinMultipleSclerosis: ImplicationsfortheRadiologist,Part1—Mechanisms,Efficacy, andSafety X C. McNamara, X G. Sugrue, X B. Murray, and X P.J. MacMahon ABSTRACT SUMMARY: Imaging for the diagnosis and follow-up of patients with suspected or confirmed multiple sclerosis is a common scenario for many general radiologists and subspecialty neuroradiologists. The field of MS therapeutics has rapidly evolved with multiple new agents now being used in routine clinical practice. To provide an informed opinion in discussions concerning newer MS agents, radiologists must have a working understanding of the strengths and limitations of the various novel therapies. The role of imaging in MS has advanced beyond monitoring and surveillance of disease activity to include treatment complications. An understanding of the new generation of MS drugs in conjunction with the key role that MR imaging plays in the detection of disease progression, opportunistic infections, and drug-related adverse events is of vital importance to the radiologist and clinical physician alike. Radiologists are in a unique position to detect many of the described complications well in advance of clinical symptoms. Part 1 of this review outlines recent developments in the treatment of MS and discusses the published clinical data on the efficacy and safety of the currentlyapprovedandemergingtherapiesinthisconditionastheyapplytotheradiologist.Part2willcoverpharmacovigilanceandtherolethe neuroradiologist plays http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png American Journal of Neuroradiology American Journal of Neuroradiology

Current and Emerging Therapies in Multiple Sclerosis: Implications for the Radiologist, Part 1—Mechanisms, Efficacy, and Safety

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Publisher
American Journal of Neuroradiology
Copyright
© 2017 by American Journal of Neuroradiology
ISSN
0195-6108
eISSN
1936-959X
DOI
10.3174/ajnr.A5147
Publisher site
See Article on Publisher Site

Abstract

REVIEWARTICLE CurrentandEmergingTherapiesinMultipleSclerosis: ImplicationsfortheRadiologist,Part1—Mechanisms,Efficacy, andSafety X C. McNamara, X G. Sugrue, X B. Murray, and X P.J. MacMahon ABSTRACT SUMMARY: Imaging for the diagnosis and follow-up of patients with suspected or confirmed multiple sclerosis is a common scenario for many general radiologists and subspecialty neuroradiologists. The field of MS therapeutics has rapidly evolved with multiple new agents now being used in routine clinical practice. To provide an informed opinion in discussions concerning newer MS agents, radiologists must have a working understanding of the strengths and limitations of the various novel therapies. The role of imaging in MS has advanced beyond monitoring and surveillance of disease activity to include treatment complications. An understanding of the new generation of MS drugs in conjunction with the key role that MR imaging plays in the detection of disease progression, opportunistic infections, and drug-related adverse events is of vital importance to the radiologist and clinical physician alike. Radiologists are in a unique position to detect many of the described complications well in advance of clinical symptoms. Part 1 of this review outlines recent developments in the treatment of MS and discusses the published clinical data on the efficacy and safety of the currentlyapprovedandemergingtherapiesinthisconditionastheyapplytotheradiologist.Part2willcoverpharmacovigilanceandtherolethe neuroradiologist plays

Journal

American Journal of Neuroradiology – American Journal of Neuroradiology

Published: Sep 1, 2017

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