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CSF Flow through the Upper Cervical Spinal Canal in Chiari I Malformation

CSF Flow through the Upper Cervical Spinal Canal in Chiari I Malformation BACKGROUND AND PURPOSE: Previous studies have quantified CSF flow in patients with Chiari I at the foramen magnum with single-axial or single-sagittal PCMR. The goal of this study was to measure CSF velocities at multiple cervical spinal levels in patients with Chiari I malformation. MATERIALS AND METHODS: In a patient registry, consecutive patients without surgery who had PCMR flow images in 5–8 axial planes between the foramen magnum and C4 were identified. Four contiguous regions were defined from the foramen magnum to C4. In each region, the fastest positive flow (PSV) and fastest negative flow (PDV) were tabulated. Changes in peak velocity by cervical spinal level and age and sex were tested for significance with linear mixed-effects models. RESULTS: In 17 patients studied, PSV increased progressively and significantly from the foramen magnum to C4. PDVs increased slightly from the foramen magnum to C3. The changes in velocity over the 4 regions tended to be smaller in the 13 patients with tonsilar ectopia than in the 4 patients without it. Age and sex had an effect on peak velocities. CONCLUSIONS: Peak diastolic and systolic CSF velocities are significantly greater below than at the foramen magnum. Abbreviations CFD computational fluid dynamics PCMR phase contrast MR imaging PDV peak diastolic velocity PSV peak systolic velocity SE standard error http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png American Journal of Neuroradiology American Journal of Neuroradiology

CSF Flow through the Upper Cervical Spinal Canal in Chiari I Malformation

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Publisher
American Journal of Neuroradiology
Copyright
Copyright © 2011 by the American Society of Neuroradiology.
ISSN
0195-6108
eISSN
1936-959X
DOI
10.3174/ajnr.A2460
pmid
21511868
Publisher site
See Article on Publisher Site

Abstract

BACKGROUND AND PURPOSE: Previous studies have quantified CSF flow in patients with Chiari I at the foramen magnum with single-axial or single-sagittal PCMR. The goal of this study was to measure CSF velocities at multiple cervical spinal levels in patients with Chiari I malformation. MATERIALS AND METHODS: In a patient registry, consecutive patients without surgery who had PCMR flow images in 5–8 axial planes between the foramen magnum and C4 were identified. Four contiguous regions were defined from the foramen magnum to C4. In each region, the fastest positive flow (PSV) and fastest negative flow (PDV) were tabulated. Changes in peak velocity by cervical spinal level and age and sex were tested for significance with linear mixed-effects models. RESULTS: In 17 patients studied, PSV increased progressively and significantly from the foramen magnum to C4. PDVs increased slightly from the foramen magnum to C3. The changes in velocity over the 4 regions tended to be smaller in the 13 patients with tonsilar ectopia than in the 4 patients without it. Age and sex had an effect on peak velocities. CONCLUSIONS: Peak diastolic and systolic CSF velocities are significantly greater below than at the foramen magnum. Abbreviations CFD computational fluid dynamics PCMR phase contrast MR imaging PDV peak diastolic velocity PSV peak systolic velocity SE standard error

Journal

American Journal of NeuroradiologyAmerican Journal of Neuroradiology

Published: Jun 1, 2011

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