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COVID-19-Associated Carotid Atherothrombosis and Stroke

COVID-19-Associated Carotid Atherothrombosis and Stroke RADIOLOGY-PATHOLOGY CORRELATION C. Esenwa, N.T. Cheng, E. Lipsitz, K. Hsu, R. Zampolin, A. Gersten, D. Antoniello, A. Soetanto, K. Kirchoff, A. Liberman, P. Mabie, T. Nisar, D. Rahimian, A. Brook, S.-K. Lee, N. Haranhalli, D. Altschul, and D. Labovitz ABSTRACT SUMMARY: We present a radiology-pathology case series of 3 patients with coronavirus disease 2019 (COVID-19) with acute ische- mic stroke due to fulminant carotid thrombosis overlying mild atherosclerotic plaque and propose a novel stroke mechanism: COVID-associated carotid atherothrombosis. ABBREVIATIONS: ACE2 ¼ angiotensin-converting enzyme 2; CCA ¼ common carotid artery; COVID-19 ¼ coronavirus disease 2019; RT-PCR ¼ reverse-tran- scriptase polymerase chain reaction; SARS-CoV-2 ¼ Severe Acute Respiratory Syndrome coronavirus 2 arotid plaque size is a predictor of ischemic stroke and We describe 3 patients with COVID-19 with acute ischemic Cguides treatment strategies. However, since 1952, when C. stroke due to fulminant carotid thrombosis overlying mild athe- Miller Fisher associated carotid atherosclerosis with stroke, there rosclerotic plaque. We review the clinical course, advanced imag- remained an unresolved question: Why did the plaque become ing, and pathologic examination and propose a previously symptomatic when it did? Inflammation has been proposed as undescribed COVID-19-related stroke mechanism. the main mediator of carotid disease, and http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png American Journal of Neuroradiology American Journal of Neuroradiology

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Publisher
American Journal of Neuroradiology
Copyright
© 2020 by American Journal of Neuroradiology
ISSN
0195-6108
eISSN
1936-959X
DOI
10.3174/ajnr.A6752
Publisher site
See Article on Publisher Site

Abstract

RADIOLOGY-PATHOLOGY CORRELATION C. Esenwa, N.T. Cheng, E. Lipsitz, K. Hsu, R. Zampolin, A. Gersten, D. Antoniello, A. Soetanto, K. Kirchoff, A. Liberman, P. Mabie, T. Nisar, D. Rahimian, A. Brook, S.-K. Lee, N. Haranhalli, D. Altschul, and D. Labovitz ABSTRACT SUMMARY: We present a radiology-pathology case series of 3 patients with coronavirus disease 2019 (COVID-19) with acute ische- mic stroke due to fulminant carotid thrombosis overlying mild atherosclerotic plaque and propose a novel stroke mechanism: COVID-associated carotid atherothrombosis. ABBREVIATIONS: ACE2 ¼ angiotensin-converting enzyme 2; CCA ¼ common carotid artery; COVID-19 ¼ coronavirus disease 2019; RT-PCR ¼ reverse-tran- scriptase polymerase chain reaction; SARS-CoV-2 ¼ Severe Acute Respiratory Syndrome coronavirus 2 arotid plaque size is a predictor of ischemic stroke and We describe 3 patients with COVID-19 with acute ischemic Cguides treatment strategies. However, since 1952, when C. stroke due to fulminant carotid thrombosis overlying mild athe- Miller Fisher associated carotid atherosclerosis with stroke, there rosclerotic plaque. We review the clinical course, advanced imag- remained an unresolved question: Why did the plaque become ing, and pathologic examination and propose a previously symptomatic when it did? Inflammation has been proposed as undescribed COVID-19-related stroke mechanism. the main mediator of carotid disease, and

Journal

American Journal of NeuroradiologyAmerican Journal of Neuroradiology

Published: Nov 1, 2020

References