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COVID-19-Associated Acute Disseminated Encephalomyelitis–Like Disease

COVID-19-Associated Acute Disseminated Encephalomyelitis–Like Disease Published December 3, 2020 as 10.3174/ajnr.A6967 LETTERS COVID-19-Associated Acute Disseminated Encephalomyelitis–Like Disease e read with great interest the article by Toledano-Massiah Even though the authors have concluded that the etiology Wet al entitled, “Unusual Brain MRI Pattern in 2 Patients and physiopathology of these unusual brain lesions are still not with COVID-19 Acute Respiratory Distress Syndrome.” The clarified, these 2 additional patients reinforce the inflammatory authors reported 2 patients hospitalized in their intensive care mechanism hypothesis. Acute disseminated encephalomyelitis unit with confirmed coronavirus disease 2019 (COVID-19) in (ADEM) is a rare immune-mediated demyelinating disease that whom brain MR imaging had shown an unusual DWI pattern has been associated with vaccine and viral infections, including with nodular and ring-shaped lesions involving the periventricu- SARS-CoV-2 infection. lar and deep white matter. Based on the recent literature, the The causative neuropathogenic mechanism of SARS-CoV- authors discussed the probable mechanism of action for Severe 2 infection should be carefully analyzed. In particular, Acute Respiratory Syndrome coronavirus disease 2 (SARS-CoV- patient 2 was asymptomatic for about 30 days, and the RT- 2) neurologic invasion. PCR test was not performed. Nevertheless, we presumed that We treated 2 hospitalized patients who share some simi- the infection http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png American Journal of Neuroradiology American Journal of Neuroradiology

COVID-19-Associated Acute Disseminated Encephalomyelitis–Like Disease

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Publisher
American Journal of Neuroradiology
Copyright
© 2021 by American Journal of Neuroradiology. Indicates open access to non-subscribers at www.ajnr.org
ISSN
0195-6108
eISSN
1936-959X
DOI
10.3174/ajnr.A6967
Publisher site
See Article on Publisher Site

Abstract

Published December 3, 2020 as 10.3174/ajnr.A6967 LETTERS COVID-19-Associated Acute Disseminated Encephalomyelitis–Like Disease e read with great interest the article by Toledano-Massiah Even though the authors have concluded that the etiology Wet al entitled, “Unusual Brain MRI Pattern in 2 Patients and physiopathology of these unusual brain lesions are still not with COVID-19 Acute Respiratory Distress Syndrome.” The clarified, these 2 additional patients reinforce the inflammatory authors reported 2 patients hospitalized in their intensive care mechanism hypothesis. Acute disseminated encephalomyelitis unit with confirmed coronavirus disease 2019 (COVID-19) in (ADEM) is a rare immune-mediated demyelinating disease that whom brain MR imaging had shown an unusual DWI pattern has been associated with vaccine and viral infections, including with nodular and ring-shaped lesions involving the periventricu- SARS-CoV-2 infection. lar and deep white matter. Based on the recent literature, the The causative neuropathogenic mechanism of SARS-CoV- authors discussed the probable mechanism of action for Severe 2 infection should be carefully analyzed. In particular, Acute Respiratory Syndrome coronavirus disease 2 (SARS-CoV- patient 2 was asymptomatic for about 30 days, and the RT- 2) neurologic invasion. PCR test was not performed. Nevertheless, we presumed that We treated 2 hospitalized patients who share some simi- the infection

Journal

American Journal of NeuroradiologyAmerican Journal of Neuroradiology

Published: Dec 3, 2020

References

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